Orantinib (SU6668)

ChemicalBook > CAS DataBase List > Orantinib (SU6668)

Product Name: Orantinib (SU6668)
CAS No.: 252916-29-3
Chemical Name: Orantinib (SU6668)
Synonyms: TSU-68;Orantinib;NSC 702827;TSU-68, >=99%;Orantinib (SU;TSU-68 (SU6668);SU 6668(TSU-68);Orantinib (SU6668;Orantinib (TSU-68);TSU-68 (Orantinib,SU6668)
CBNumber: CB31456201
Molecular Formula: C18H18N2O3
Formula Weight: 310.35
MOL File: 252916-29-3.mol

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Orantinib (SU6668) Property

Melting point:: 252-254 °C
Boiling point:: 590.5±50.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4?+-.0.10(Predicted)
color: Orange to Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13873
Product name: SU 6668
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 13873
Product name: SU 6668
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 13873
Product name: SU 6668
Purity: ≥98%
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Usbiological

Product number: 022488
Product name: TSU-68
Packaging: 10mg
Price: $396
Updated: 2021/12/16

TRC

Product number: T797550
Product name: TSU-68
Packaging: 50mg
Price: $425
Updated: 2021/12/16

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Orantinib (SU6668) Chemical Properties,Usage,Production

Uses

TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 towards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.

Uses

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.

Definition

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth facto receptor 1.

Biological Activity

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC 50 values are 0.06, 2.43, 3.04 and > 100 μ M at PDGFR β , VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC 50 values are 0.41, 9.3 and 16.5 μ M for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo . Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

in vitro

biochemical kinetic studies using isolated flk-1, fgf receptor 1, and pdgf receptor β kinases revealed that tsu-68 has competitive inhibitory properties with respect to atp. in cellular systems, tsu-68 inhibited receptor tyrosine phosphorylation and mitogenesis after stimulation of cells by appropriate ligands [1].

in vivo

oral or i.p. administration of tsu-68 in athymic mice resulted in significant growth inhibition of a diverse panel of human tumor xenografts of glioma, melanoma, lung, colon, ovarian, and epidermoid origin [1].

storage

Store at RT

References

[1] laird ad, vajkoczy p, shawver lk et al. su6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. cancer res. 2000 aug 1;60(15):4152-60.
[2] okamoto i, yoshioka h, takeda k et al. phase i clinical study of the angiogenesis inhibitor tsu-68 combined with carboplatin and paclitaxel in chemotherapy-naive patients with advanced non-small cell lung cancer. j thorac oncol. 2012 feb;7(2):427-33.

Orantinib (SU6668) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Orantinib (SU6668) manufacturers

Career Henan Chemical Co

Product: 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid 252916-29-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-13

252916-29-3, Orantinib (SU6668)Related Search:

1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Pazopanib Nintedanib Regorafenib Ponatinib Dovitinib Capecitabine Derazantinib MK-2206 2HCl JNJ-7706621 Lenvatinib BI-D1870 PLX4032 AT9283

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

TSU-68

5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

(Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid

TSU-68 (SU6668)

1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-

SU 6668(TSU-68)

(E)-3-(2,4-diMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid

NSC 702827

TSU-68 (SU6668, Orantinib)

Orantinib

3-(2,4-DiMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid

5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid TSU-68 (SU6668, Orantinib)

TSU-68, >=99%

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid TSU-68

(Z)-3-[2,4-Dimethyl-5-(2-oxo-2,3-dihydro-1H-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic acid

TSU-68 (SU6668, ORANTINIB);SU 6668;TSU68

ORANTINIB;SU6668;SU 6668;NSC 702827

Orantinib (SU6668

ORANTINIB (SU6668; TSU-68)

Orantinib (TSU-68)

TSU-68;SU6668; NSC 702827;TSU 68;TSU68

TSU-68 (Orantinib,SU6668)

Orantinib (TSU-68, SU6668)

Orantinib (SU6668) USP/EP/BP

Orantinib SU6668 PDGFR inhibitor ab142156 SU-6668 tsu68 tsu-68

Orantinib (SU

252916-29-3

API

Angiogenesis and Metastasis

Inhibitors