4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid

Product Name: 4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid
CAS No.: 216167-82-7
Chemical Name: 4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid
Synonyms: AGI 1067;AGZ-1067;SUCCINOBUCOL;AGI 1067 ，S6420;Flunixin Monomer;SUCCINOBUCOL, >98%;Probucol Monosuccinate;Succinobucol(AGI 1067);Succinobucol, 10 mM in DMSO;Probucol monosuccinate, >98%
CBNumber: CB31458896
Molecular Formula: C35H52O5S2
Formula Weight: 616.91
MOL File: 216167-82-7.mol

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4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid Property

Melting point:: 139 - 142°C
Boiling point:: 659.5±55.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 4.27±0.17(Predicted)
form: Solid
color: White to Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S688775
Product name: Succinobucol
Packaging: 25mg
Price: $135
Updated: 2021/12/16

TRC

Product number: S688775
Product name: Succinobucol
Packaging: 50mg
Price: $175
Updated: 2021/12/16

TRC

Product number: S688775
Product name: Succinobucol
Packaging: 100mg
Price: $320
Updated: 2021/12/16

Usbiological

Product number: 289222
Product name: Succinobucol
Packaging: 25mg
Price: $460
Updated: 2021/12/16

TRC

Product number: S688775
Product name: Succinobucol
Packaging: 250mg
Price: $790
Updated: 2021/12/16

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4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid Chemical Properties,Usage,Production

Uses

An antioxidant and anti-inflammatory.

Definition

ChEBI: Succinobucol is a benzoate ester and a member of phenols.

Biological Activity

Succinobucol is a metabolically stable derivative of the antioxidant drug probucol th at poses a distinct pharmacological from. Succinobucol is an orally active vascular protectant th at exhibits antiatherosclerotic properties in multiple animal models and in humans. It inhibits the release of proinflammatory cytokines, TNF-a, IL-1b, and IL-6 in hPBMC activated by LPS.

in vivo

Succinobucol (50, 100, and 150 mg/kg, i.v.) has no significant effect on either heart rate or MAP, but the blood removed 15 minutes after the final injection of succinobucol shows significantly less aggregation in response to collagen at both 5 μg/mL and 20 μg/mL in rats^[1]. Succinobucol (40 mg/kg) by tail injection significantly reduces the average number of metastatic nodules in lung metastatic breast cancer mice^[3].

4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid Suppliers

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216167-82-7, 4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acidRelated Search:

BIS(PHENYLTHIO)METHANE Probucol ELSIBUCOL 2-Bromopyridine 4-[4-[2-(4-hydroxy-3,5-ditert-butyl-phenyl)sulfanylpropan-2-ylsulfanyl]-2,6-ditert-butyl-phenoxy]-4-oxo-butanoic acid

SUCCINOBUCOL

AGI-1067;PROBUCOL MONOSUCCINATE

Probucol monosuccinate, >98%

SUCCINOBUCOL, >98%

AGZ-1067

AGZ1067. Probucol monosuccinae

SUCCINOBUCOL; AGI-1067; AGZ-1067; AGI1067; AGZ1067. PROBUCOL MONOSUCCINAE

Succinobucol(AGI 1067)

Butanedioic Acid 1-[4-[[1-[[3,5-Bis(1,1-diMethylethyl)-4-hydroxyphenyl]thio]-1-Methylethyl]thio]-2,6-bis(1,1-diMethylethyl)phenyl] Ester

Probucol Monosuccinate

AGI 1067

4-(2,6-di-tert-butyl-4-(2-(3,5-di-tert-butyl-4-hydroxyphenylthio)propan-2-ylthio)phenoxy)-4-oxobutanoic acid

2H-1-Benzopyran-2-one,6-bromo-3,7-dihydro-

Inhibitor,inhibit,AGI 1067,Succinobucol,Reactive Oxygen Species,AGI1067

Flunixin Monomer

4-[2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenoxy]-4-oxobutanoic acid

Succinobucol, 10 mM in DMSO

AGI 1067 ，S6420

216167-82-7

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds