ChemicalBook > CAS DataBase List > alpha,alpha-Diphenyl-4-piperidinomethanol

alpha,alpha-Diphenyl-4-piperidinomethanol

Product Name
alpha,alpha-Diphenyl-4-piperidinomethanol
CAS No.
115-46-8
Chemical Name
alpha,alpha-Diphenyl-4-piperidinomethanol
Synonyms
AZACYCLONOL;ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL;Azacyclanol;alpha,alpha-diphenyl-4-piperidinemethano;mer17;MER 17;Calmeran;Frenquel;Frenoton;MDL 4829
CBNumber
CB3146211
Molecular Formula
C18H21NO
Formula Weight
267.37
MOL File
115-46-8.mol
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alpha,alpha-Diphenyl-4-piperidinomethanol Property

Melting point:
160-163 °C
Boiling point:
410.55°C (rough estimate)
Density 
1.0449 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5100 (estimate)
storage temp. 
Store below +30°C.
solubility 
Chloroform, Methanol (Slightly, Sonicated)
pka
13.32±0.29(Predicted)
form 
Solid
color 
White to light beige
InChIKey
ZMISODWVFHHWNR-UHFFFAOYSA-N
CAS DataBase Reference
115-46-8(CAS DataBase Reference)
NIST Chemistry Reference
Azacyclonol(115-46-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
WGK 3 highly water endangering
RTECS 
TN0470000
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14973
Product name
Diphenyl-4-piperidinemethanol
Purity
for synthesis
Packaging
25g
Price
$121
Updated
2024/03/01
TCI Chemical
Product number
P1369
Product name
α-(4-Piperidyl)benzhydrol
Purity
>99.0%(GC)(T)
Packaging
5g
Price
$39
Updated
2024/03/01
TCI Chemical
Product number
P1369
Product name
α-(4-Piperidyl)benzhydrol
Purity
>99.0%(GC)(T)
Packaging
25g
Price
$123
Updated
2024/03/01
Alfa Aesar
Product number
H61281
Product name
Diphenyl(4-piperidinyl)methanol, 95%
Packaging
25g
Price
$70.9
Updated
2021/12/16
Alfa Aesar
Product number
H61281
Product name
Diphenyl(4-piperidinyl)methanol, 95%
Packaging
100g
Price
$219
Updated
2021/12/16
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alpha,alpha-Diphenyl-4-piperidinomethanol Chemical Properties,Usage,Production

Description

alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.

Chemical Properties

α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.

Originator

Frenquel,Merrell,US,1955

Uses

Anxiolytic;H1 antagonist

Uses

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.

Definition

ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.

Manufacturing Process

A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.

brand name

Frenquel (Marion Merrell Dow).

Therapeutic Function

Tranquilizer

alpha,alpha-Diphenyl-4-piperidinomethanol Preparation Products And Raw materials

Raw materials

Preparation Products

Terfenadine
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View Lastest Price from alpha,alpha-Diphenyl-4-piperidinomethanol manufacturers

Qingdao RENAS Polymer Material Co., Ltd.
Product
alpha,alpha-Diphenyl-4-piperidinemethanol 115-46-8
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-10-29
Shanghai CRM New Material Technology Co., LTD
Product
Azacyclonol 115-46-8
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
10t
Release date
2022-09-21
Qiuxian Baitai New Material Co., LTD
Product
alpha,alpha-Diphenyl-4-piperidinomethanol 115-46-8
Price
US $26.00/g
Min. Order
1KG
Purity
99%
Supply Ability
5ton/Month
Release date
2021-12-13

115-46-8, alpha,alpha-Diphenyl-4-piperidinomethanolRelated Search:

Chlorodiphenylphosphine α-Lipoic Acid Diphenylthiocarbazide 1,3-Diphenyl-2-thiourea Dithizone 4-Aminobutyric acid Diethylstilbestrol 1,5-Diphenylcarbazide Biphenyl 4-Piperidinemethanol Dichlorodiphenylsilane Diphenyldimethoxysilane Diphenyl-2-pyridylphosphine ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL, HYDROCHLORIDE,ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL HCL Terfenadine Ethyl 4-{4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl}-alpha,alpha-dimethylbenzeneacetate hydrochloride TERFENADINE IMP.I (EP):DIPHENYL(PIPERIDIN-4-YLMETHANOL(AZACYCLONOL) Fexofenadine hydrochloride

  • TIMTEC-BB SBB003057
  • 4-Piperidinemethanol, alpha,alpha-diphenyl-
  • alpha,alpha-diphenyl-4-piperidinemethano
  • Ataractan
  • Azacyklonol
  • Calmeran
  • Diphenyl(4-piperidinyl)methanol
  • Diphenyl-4-piperidylmethanol
  • Frenoton
  • Frenquel
  • MER 17
  • mer17
  • Azacyclonol (base and/or unspecified salts)
  • AZACYCLONOL (ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL)
  • 4-[Hydroxy(diphenyl)methyl]piperidine
  • Diphenyl(piperidin-4-yl)methanol, Azacyclonol, alpha-(Piperidin-4-yl)benzhydrol
  • α-(4-Piperidyl)benzhydrol
  • alpha,alpha-Diphenyl-4-piperidinoMethanol, 98+% 5GR
  • 4-(DiphenylhydroxyMethyl)piperidine
  • MDL 4829
  • DIPHENYL-4-PIPERIDINEMETHANOL FOR SYNTHE
  • a-(4-Piperidyl)benzhydrol
  • Psychosa
  • α,α-Diphenyl-4-piperidinomethanol
  • a, a- Azacyclonol
  • 4-PiperidineMethanol, a,a-diphenyl-
  • phenyl(4-(piperidin-1-yl)phenyl)methanol
  • ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE METHONOL
  • Diphenyl-4-piperidinemethanol for synthesis
  • α, α-Diphenyl-4-piperidinomethanol, 98+%
  • Fexofenadine hydrochloride impurity E (EP)
  • Fexofenadine EP Impurity E
  • Terfenadine Impurity 1
  • Psychosan
  • Azacyclonol Base
  • AzacyclonolBase98%
  • ALPHA,ALPHA-DIPHENYL-4-PIPERIDINEMETHANOL
  • ALPHA,ALPHA-DIPHENYL-4-PIPERIDINOMETHANOL
  • ALPHA-(4-PIPERIDYL)BENZHYDROL
  • A,A-DIPHENYL-4-PIPERIDINEMETHANOL
  • 4-(ALPHA,ALPHA DIPHENYL) PIPERIDINE METHANOL
  • 2,2-DIPHENYL-4-PIPERIDONOMETHANOL
  • AZACYCLONAL
  • AZACYCLONOL
  • DIPHENYL-4-PIPERIDINEMETHANOL
  • DIPHENYL-PIPERIDIN-4-YL-METHANOL
  • gamma-pipradol
  • α,α-Diphenyl-4-piperidinylcarbinol
  • alpha,alpha-Diphenyl-4-piperidinomethanol, 98+%
  • alpha,alpha-Diphenyl-4-piperid
  • AZACYCLONOL A , A -DIPHENYL-4-PIPERIDINEMETHANOL
  • Fexofenadine Related Compound E
  • ALPHA ALPHA -DIPHENYL-4-PIPERDINEMETHANO L
  • Fexofenadine Impurity 5（Fexofenadine EP Impurity E）
  • ALPHA, ALPHA-DIPHENYL-4-PIPERIDINE
  • α-(4-Piperidyl)benzhydrol&gt
  • Diphenyl(piperidin-4-yl)methanol (A
  • 4-Piperidinemethanol, α,α-diphenyl-