Ethopropazine Hydrochloride

Product Name: Ethopropazine Hydrochloride
CAS No.: 1094-08-2
Chemical Name: Ethopropazine Hydrochloride
Synonyms: parfezin;NSC 64074;NSC 169467;PROFENAMIN HCL;ProphenamineHCl;Profenamine HCl;ethopropazine hcl;Ethopropazine hydroc;lysivanehydrochloride;parsidolhydrochloride
CBNumber: CB3149595
Molecular Formula: C19H25ClN2S
Formula Weight: 348.93
MOL File: 1094-08-2.mol

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Ethopropazine Hydrochloride Property

Melting point:: 223-225° (some decompn)
storage temp.: 2-8°C
solubility: DMSO: >5mg/mL at ~60°C, clear
form: powder
color: white
Merck: 13,3783
Stability:: Hygroscopic

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: SO5002000
Toxicity: LD50 s.c. in mice: 670 mg/kg (Farquharson, Johnston)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E5406
Product name: Ethopropazine hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 50mg
Price: $208
Updated: 2024/03/01

Sigma-Aldrich

Product number: E5406
Product name: Ethopropazine hydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 250mg
Price: $922
Updated: 2024/03/01

Cayman Chemical

Product number: 28493
Product name: Ethopropazine (hydrochloride)
Packaging: 10mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 28493
Product name: Ethopropazine (hydrochloride)
Packaging: 25mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 28493
Product name: Ethopropazine (hydrochloride)
Packaging: 50mg
Price: $194
Updated: 2024/03/01

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Ethopropazine Hydrochloride Chemical Properties,Usage,Production

Originator

Parsidol,Warner Lambert,US,1954

Uses

Ethopropazine hydrochloride is a drug that shifts energy metabolism from mitochondrial respiration to glycolysis.

Uses

Antiparkinsonian;Anticholinergic

Definition

ChEBI: The monohydrochloride salt of profenamine. An antimuscarinic, it is used for the symptomatic treatment of Parkinson's disease.

Manufacturing Process

6.2 grams of phenthiazine in 100 cc of warm dry benzene was added during 1 hour with stirring, and in an atmosphere of hydrogen, to the Grignard reagent prepared from 1 gram of magnesium, 6.2 grams of methyl iodide, and 20 cc of dry ether. After boiling for 30 minutes, a solution of 6.6 grams of 2-chloro- 1-diethylamino propane in 10 cc of dry benzene was added during 1 hour to the boiling solution, and heating was maintained for a further 1.5 hours.
The reaction mixture was then cooled and treated with aqueous ammonium chloride and chloroform added to dissolve an oil at the interface of the benzene and aqueous layers. The chloroform-benzene extract was extracted with 2 N hydrochloric acid and the acid extract was basified at 5° to 10°C with 50% aqueous sodium hydroxide.
There was obtained a mixture of N-(2'-diethylamino-2'- methylethyl)phenthiazine and N-(2'-diethylamino-1'-methylethyl)phenthiazine in the form of a viscous yellow oil, BP 202° to 205°C/2 mm. This oil was treated in ethereal solution with ethereal hydrogen chloride and gave a white solid which was fractionally crystallized from ethylene dichloride. The less soluble fraction, N-(2'-diethylamino-2'-methylethyl)phenthiazine hydrochloride formed colorless rhombs, MP 223° to 225°C. The more soluble N-(2'- diethylamino-1'-methylethyl)phenthiazine hydrochloride was obtained as colorless prismatic needles, MP 166° to 168°C.

Therapeutic Function

Antiparkinsonian

General Description

Ethopropazinehydrochloride, 10-[2-(diethylamino)propyl]phenothiazinemonohydrochloride (Parsidol), introduced to therapy in1954, has antimuscarinic activity and is especially useful inthe symptomatic treatment of parkinsonism. In this capacity,it has value in controlling rigidity, and it also has a favorableeffect on tremor, sialorrhea, and oculogyric crises.

Biochem/physiol Actions

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

Clinical Use

Ethopropazine Hydrochloride is oftenused in conjunction with other antiparkinsonian drugs forcomplementary activity.Side effects are common with this drug but are usuallynot severe. Drowsiness and dizziness are the most commonside effects at ordinary dosage levels, and as the dose increases,xerostomia, mydriasis, and others become evident.It is contraindicated in conditions such as glaucoma becauseof its mydriatic effect.

Ethopropazine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1094-08-2, Ethopropazine HydrochlorideRelated Search:

2-Aminoethylammonium chloride diethazine Phenothiazine 10-METHYLPHENOTHIAZINE 2-(Phenylthio)aniline Ethopropazine Hydrochloride 1-(DIMETHYLAMINO)ISOPROPYLAMINE N-Methyldiphenylamine Promethazine hydrochloride ETHOPROPAZINE fenethazine Diphenyl sulfide DIPHENYLAMINE HYDROCHLORIDE N,N,N',N'-TETRAMETHYL-1,2-DIAMINOPROPANE N-(2-amino-1-methylethyl)-N,N-diethylamine N,N-DIETHYL-N',N'-DIMETHYLETHYLENE DIAMINE N,N-DIETHYL-N'-PHENYLETHYLENEDIAMINE N-MONODESMETHYL PROMETHAZINE

lysivanehydrochloride

n,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethanaminmonohydrochloride

n,n-diethyl-alpha-methyl-10-phenothiazineethylaminhydrochloride

profenaminemonohydrochloride

ethopropazine hcl

10H-Phenothiazine-10-ethanamine, N,N-diethyl-.alpha.-methyl-, monohydrochloride

10H-Phenothiazine-10-ethanamine, N,N-diethyl-a-methyl-, monohydrochloride (9CI)

NSC 169467

NSC 64074

Phenothiazine, 10-[2-(diethylamino)propyl]-, hydrochloride (7CI)

Phenothiazine, 10-[2-(diethylamino)propyl]-, monohydrochloride (8CI)

10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin

N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethylamine monohydrochloride

ProphenamineHCl

10-[2-(Diethylamino)propyl]phenothiazine hydrochloride

N-(2-diethylaMinopropyl)-phenothiazine hydrochloride

N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride

parfezin

parsidolhydrochloride

parsidolmonohydrochloride

profenaminehydrochloride

10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE

LABOTEST-BB LT00452011

ETHOPROPAZINE HYDROCHLORIDE

SALOR-INT L308765-1EA

10-(2-(diethylamino)propyl)-phenothiazinmonohydrochloride

isothazinehydrochloride

l-10-(2-diethylaminopropyl)phenothiazinehydrochloride

Ethopropazine hydrochloride >=98% (HPLC), powder

PROFENAMIN HCL

Ethopropazine hydroc

Profenamine HCl

1094-08-2

C19H24N2SHCl

C19H25ClN2S