ChemicalBook > CAS DataBase List > 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER

Product Name
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
CAS No.
208517-35-5
Chemical Name
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
Synonyms
Ethyl 2-(trifluoromethyl)nicotinate;2-Trifluoromethyl-nicotinic acid ethyl ester;ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
CBNumber
CB31500218
Molecular Formula
C9H8F3NO2
Formula Weight
219.16
MOL File
208517-35-5.mol
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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Property

Boiling point:
235.8±40.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.38±0.22(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E937090
Product name
Ethyl2-(Trifluoromethyl)nicotinate
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-3-18
Product name
Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
Purity
97%
Packaging
1g
Price
$214
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-3-18
Product name
Ethyl 2-(trifluoromethyl)pyridine-3-carboxylate
Purity
97%
Packaging
250mg
Price
$73
Updated
2021/12/16
Matrix Scientific
Product number
083416
Product name
Ethyl 2-(trifluoromethyl)nicotinate
Purity
97%
Packaging
1g
Price
$78
Updated
2021/12/16
Matrix Scientific
Product number
083416
Product name
Ethyl 2-(trifluoromethyl)nicotinate
Purity
97%
Packaging
5g
Price
$272
Updated
2021/12/16
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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Yellow liquid

Synthesis

1146961-22-9

208517-35-5

In a 1 L single neck round bottom flask equipped with a magnetic stirrer and a reflux condenser, ethyl (2E,4E)-5-(dimethylamino)-2-(2,2,2-trifluoroacetyl)penta-2,4-dienoate (80.50 g, 303.8 mmol) was dissolved in a solvent mixture of methanol (700 mL) and 25% aqueous ammonia solution (240 mL). The reaction mixture was heated to 70 °C and maintained for 20 minutes. It was then cooled to room temperature and the methanol was removed by distillation under reduced pressure. The residue was diluted with water (200 mL) and extracted with ether (2 x 300 mL). The organic phases were combined, washed with saturated brine (200 mL), dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure to give 65.0 g of red oily crude product. The crude product was pure enough for subsequent reactions. For further purification, the crude product was filtered through a short silica gel column, followed by evaporation of the filtrate to give 59.9 g of light yellow flowing oil in 90% yield.

References

[1] Patent: WO2009/54742, 2009, A2. Location in patent: Page/Page column 13-14

2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER Suppliers

China 109 India 3 United Kingdom 2 United States 7 Global 121
Apollo Scientific Ltd.
Tel
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Fax
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Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Atlantic Research Chemicals Ltd.
Tel
--
Fax
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Email
info@atlantic-chemicals.com
Country
United Kingdom
ProdList
5618
Advantage
63
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View Lastest Price from 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER manufacturers

Dideu Industries Group Limited
Product
2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 208517-35-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
Ethyl 2-(trifluoromethyl)nicotinate 208517-35-5
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

208517-35-5, 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTERRelated Search:

ETHYL STEARATE 2-(Trifluoromethyl)nicotinic acid Ethyl nicotinate 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER 1,8-Naphthyridine-3-carboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) ETHYL 5-CYANO-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE DIETHYL 3-AMINO-6-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2,5-DICARBOXYLATE ETHYL 2-CHLORO-3-CYANO-6-(TRIFLUOROMETHYL)-PYRIDINE-5-CARBOXYLATE RARECHEM AL BW 1871 ETHYL 5-(AMINO([(2,3,3-TRICHLOROALLANOYL)OXY]IMINO)METHYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE RARECHEM AL BW 1646 BUTTPARK 82\12-87 ETHYL 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 5-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID, ETHYL ESTER ETHYL 5-(AMINOCARBOTHIOYL)-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE ETHYL 5-CYANO-6-([2-(([(2,6-DICHLORO-4-PYRIDYL)AMINO]CARBONYL)AMINO)PHENYL]THIO)-2-(TRIFLUOROMETHYL)NICOTINATE 2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ETHYL ESTER DIETHYL 2-METHYL-6-(TRIFLUOROMETHYL)PYRIDINE-3,5-DICARBOXYLATE

  • 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER
  • 2-Trifluoromethyl-nicotinic acid ethyl ester
  • Ethyl 2-(trifluoromethyl)nicotinate
  • ethyl 2-(trifluoroMethyl)pyridine-3-carboxylate
  • 2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH
  • 208517-35-5
  • Building Blocks
  • Pyridine