N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
- Product Name
- N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
- CAS No.
- 199522-66-2
- Chemical Name
- N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
- Synonyms
- N1-(5-Bromopyrid-2-yl);N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine;N1-(5-Bromo-2-pyridinyl)-1,2-ethanediamine;1,2-Ethanediamine, N1-(5-bromo-2-pyridinyl)-
- CBNumber
- CB31501679
- Molecular Formula
- C7H10BrN3
- Formula Weight
- 216.08
- MOL File
- 199522-66-2.mol
N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine Property
- Boiling point:
- 327.5±37.0 °C(Predicted)
- Density
- 1.560±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.06±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 150536
- Product name
- N1-(5-Bromopyridin-2-yl)ethane-1,2-diamine
- Purity
- 95%
- Packaging
- 1g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- 150536
- Product name
- N1-(5-Bromopyridin-2-yl)ethane-1,2-diamine
- Purity
- 95%
- Packaging
- 5g
- Price
- $474
- Updated
- 2021/12/16
- Product number
- HCH0028073
- Product name
- N-(5-BROMOPYRIDIN-2-YL)ETHANE-1,2-DIAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.5
- Updated
- 2021/12/16
- Product number
- 0255AB
- Product name
- N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
- Packaging
- 5g
- Price
- $658
- Updated
- 2021/12/16
- Product number
- A470814
- Product name
- N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
- Purity
- 96%
- Packaging
- 100mg
- Price
- $47
- Updated
- 2021/12/16
N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine Chemical Properties,Usage,Production
Synthesis
624-28-2
107-15-3
199522-66-2
The general procedure for the synthesis of N1-(5-bromopyridin-2-yl)ethane-1,2-diamine from 2,5-dibromopyridine and ethylenediamine was as follows: 1 g (4.22 mmol) of 2,5-dibromopyridine was dissolved in 10 mL of ethylenediamine, and the resulting solution was stirred and reacted for 15 hours at 100 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the excess ethylenediamine was removed by distillation under reduced pressure. Subsequently, the concentrate was diluted by adding 50 mL of dichloromethane to the concentrate and the diluted solution was washed with 30 mL of distilled water. The aqueous phase was extracted twice with 50 mL of dichloromethane to recover the residual organic product. All organic layers were combined, dried with anhydrous sodium sulfate, and then concentrated under reduced pressure to afford 0.89 g (4.12 mmol) of the target compound N1-(5-bromopyridin-2-yl)ethane-1,2-diamine as a light yellow liquid in 98% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.10 (d, J = 1.6 Hz, 1H), 7.45 (dd, J1 = 8.8 Hz, J2 = 2.4 Hz, 1H), 6.33 (d, J = 8.8 Hz, 1H), 4.95 (brs, 1H), 3.34 (q, J = 6 Hz, 2H), 2.94 (t , J = 6 Hz, 2H).
References
[1] Patent: EP2692727, 2014, A2. Location in patent: Paragraph 0102-0103
[2] Patent: US2014/179691, 2014, A1. Location in patent: Paragraph 0112-0114
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 24, p. 4693 - 4705
[4] Patent: WO2017/106064, 2017, A1. Location in patent: Page/Page column 60
N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine Preparation Products And Raw materials
Raw materials
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