2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER

Uses

Product Name: 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER
CAS No.: 94413-64-6
Chemical Name: 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER
Synonyms: Methyl 2-cyanois;2-cyanoisonicotinate;Methyl 2-cyanoisonicotinae;Methyl 2-cyanoisonicotinate;Methyl2-cyanoisonicotinate,97%;2-Cyano-4-carbomethoxypyridine;2-Cyanoisonicotinate methyl ester;Methyl 2-cyano-4-pyridinecarboxylate;Methyl 2-cyanopyridine-4-carboxylate;2-Cyanoisonicotinic acid methyl ester
CBNumber: CB3150313
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 94413-64-6.mol

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2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Property

Melting point:: 107-109℃
Boiling point:: 296.6±25.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -2.43±0.10(Predicted)
form: Solid
color: Pale brown
Water Solubility: Slightly Soluble in water (6.2 g/L) (25°C).
InChI: InChI=1S/C8H6N2O2/c1-12-8(11)6-2-3-10-7(4-6)5-9/h2-4H,1H3
InChIKey: ORVHMLCJEKDDAX-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=CC(C(OC)=O)=C1

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Safety

HazardClass: 6.1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C987555
Product name: 2-Cyano-4-pyridinecarboxylicAcidMethylEster
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: J99596
Product name: Methyl2-cyanoisonicotinate
Packaging: 100g
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-W006243
Product name: Methyl2-cyanoisonicotinate
Purity: 99.61%
Packaging: 100g
Price: $227
Updated: 2021/12/16

Matrix Scientific

Product number: 073823
Product name: Methyl 2-cyanoisonicotinate
Purity: 95+%
Packaging: 5g
Price: $320
Updated: 2021/12/16

Matrix Scientific

Product number: 073823
Product name: Methyl 2-cyanoisonicotinate
Purity: 95+%
Packaging: 10g
Price: $590
Updated: 2021/12/16

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2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

2-Cyano-4-pyridinecarboxylic Acid Methyl Ester, can be used in the synthesis of various pharmaceutical and biologically active compounds, such as tetrasubstituted imidazolines as potent and selective neuropeptide Y (NPY) Y5 receptor antagonists.

Uses

Methyl 2-cyanoisonicotinate can be used in the synthesis of various pharmaceutical and biologically active compounds, such as tetra substituted imidazolines as potent and selective neuropeptide Y (NPY) Y5 receptor antagonists.

Synthesis

557-21-1

26156-48-9

94413-64-6

General procedure for the synthesis of methyl 2-cyano-4-pyridinecarboxylate from zinc cyanide and methyl 2-bromopyridine-4-carboxylate: methyl 2-bromopyridine-4-carboxylate (17.4 g, 80.5 mmol) was dissolved in N,N-dimethylformamide (DMF, 160 mL), and then zinc cyanide (Zn(CN)2, 5.7 g, 48.53 mmol) was added in a single step . The reaction mixture was degassed with nitrogen followed by the addition of tetrakis(triphenylphosphine)palladium (Pd(PPh3)4, 4.7 g). The mixture was again degassed and then the reaction was heated in an oil bath at 120 °C. After 2.5 hours of reaction, the reaction mixture was cooled to room temperature and water (200 mL) was added. The mixture was stirred for 30 minutes and subsequently filtered through a glass sand core funnel. The collected solid was washed with distilled water (2 x 100 mL) and then dried under vacuum to afford methyl 2-cyano-4-pyridinecarboxylate in 84% yield (11.0 g, 67.9 mmol). Electrospray mass spectrometry (ESI-MS) analysis showed [M + H]+ m/z 163.2 (C8H5N2O2 + H, calculated value: 162.1). The obtained product, methyl 2-cyano-4-pyridinecarboxylate, can be directly used in the subsequent reaction without further purification.

References

[1] Patent: US9139612, 2015, B2. Location in patent: Page/Page column 153; 154; 159
[2] Patent: US2017/100390, 2017, A1. Location in patent: Paragraph 1104
[3] Patent: WO2018/170465, 2018, A1. Location in patent: Paragraph 248

2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER Suppliers

China 204 Germany 1 India 5 United Kingdom 1 United States 15 Global 226

Jinan LuoHe PharmaTech Co., Ltd.

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View Lastest Price from 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: methyl 2-cyanopyridine-4-carboxylate 94413-64-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Methyl 2-cyanoisonicotinate 94413-64-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-11

Shaanxi Dideu Medichem Co. Ltd

Product: 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER 94413-64-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

94413-64-6, 2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTERRelated Search:

2-CYANO-4-PYRIDINE CARBOXYLIC ACID Topiroxostat 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI) diazenyl-(1-hydroxypyridin-4-ylidene)methanol Topiroxostat Impurity 9 Pyridine, 4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-, 1-oxide 4-Cyanopyridine N-oxide 4,4'-(1H-1,2,4-Triazole-3,5-diyl)dipyridine Topiroxostat Impurity 6 4-Cyanopyridine 2-Cyanopyridine 3-Cyanopyridine Topiroxostat Impurity 15 Methyl nicotinate Topiroxostat Impurity 5 METHYLISONICOTINATE-N-OXIDE Topiroxostat Impurity 23 4-PYRIDINECARBOXIMIDIC ACID, HYDRAZIDE

Methyl 2-cyanoisonicotinate

Methyl 2-cyanopyridine-4-carboxylate

2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER

Methyl 2-cyanois

4-Pyridinecarboxylicacid, 2-cyano-, Methyl ester

2-Cyano-4-carbomethoxypyridine

F2-Cyano-4-Pyridine Carboxylic Acid Methyl Ester

Methyl 2-cyano-4-pyridinecarboxylate

2-cyanoisonicotinate

Methyl2-cyanoisonicotinate,97%

2-CYANO-4-PYRIDINE CARBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH

Methyl 2-cyanoisonicotinae

2-Cyanoisonicotinic acid methyl ester

2-Cyanoisonicotinate methyl ester

94413-64-6