ChemicalBook > CAS DataBase List > 2,4-Dichloro-8-methoxyquinazoline
2,4-Dichloro-8-methoxyquinazoline
- Product Name
- 2,4-Dichloro-8-methoxyquinazoline
- CAS No.
- 61948-60-5
- Chemical Name
- 2,4-Dichloro-8-methoxyquinazoline
- Synonyms
- 2,4-Dichloro-8-methoxyquizoline;2,4-Dichloro-8-methoxyquinazoline;8-Methoxy-2,4-dichloroquinazoline;Quinazoline, 2,4-dichloro-8-methoxy-
- CBNumber
- CB31504498
- Molecular Formula
- C9H6Cl2N2O
- Formula Weight
- 229.06
- MOL File
- 61948-60-5.mol
More
Less
2,4-Dichloro-8-methoxyquinazoline Property
- Melting point:
- 157-159 °C
- Boiling point:
- 315.9±24.0 °C(Predicted)
- Density
- 1.450
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.84±0.30(Predicted)
- Appearance
- White to off-white Solid
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- D434290
- Product name
- 2,4-Dichloro-8-methoxyquinazoline
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
TRC
- Product number
- D434290
- Product name
- 2,4-Dichloro-8-methoxyquinazoline
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
AK Scientific
- Product number
- W7401
- Product name
- 2,4-Dichloro-8-methoxyquinazoline
- Packaging
- 5g
- Price
- $837
- Updated
- 2021/12/16
AK Scientific
- Product number
- W7401
- Product name
- 2,4-Dichloro-8-methoxyquinazoline
- Packaging
- 250mg
- Price
- $126
- Updated
- 2021/12/16
Ambeed
- Product number
- A218658
- Product name
- 2,4-Dichloro-8-methoxyquinazoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
More
Less
2,4-Dichloro-8-methoxyquinazoline Chemical Properties,Usage,Production
Chemical Properties
White flocculent solid
Uses
2,4-Dichloro-8-methoxyquinazoline has been used as a reactant for the preparation of p97 ATPase inhibitors.
Synthesis
62484-14-4
61948-60-5
General procedure for the synthesis of 2,4-dichloro-8-methoxyquinazoline from 8-methoxyquinazoline-2,4(1H,3H)-dione: 8-methoxyquinazoline-2,4-diol (5.5 g, 28.6 mmol) prepared in step 1 was mixed with phosphorochloridic acid chloride (25 ml) and the reaction was stirred under reflux conditions overnight. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 7-8 with sodium hydroxide solution.Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1) to afford the target product 2,4-dichloro-8-methoxyquinazoline (2.1 g) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.83 (d, 1H), 7.65 (t, 1H), 7.34 (d, 1H), 4.09 (s, 3H).
References
[1] Patent: WO2016/200840, 2016, A1. Location in patent: Page/Page column 433
[2] Patent: WO2014/101113, 2014, A1. Location in patent: Paragraph 0165
[3] Patent: WO2014/101120, 2014, A1. Location in patent: Paragraph 0124
[4] Patent: WO2014/105666, 2014, A1. Location in patent: Paragraph 0116
[5] Patent: WO2014/101373, 2014, A1. Location in patent: Page/Page column 43; 44
2,4-Dichloro-8-methoxyquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2,4-Dichloro-8-methoxyquinazoline Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- +86-21-68182121
- Fax
- +86-21-68182121
- Country
- China
- ProdList
- 882
- Advantage
- 52
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 021-64968085,64968086-5815,5812; 13472757003
- Fax
- +86 21 64968087
- xiaoxia.zeng@rainbowpharma.cn
- Country
- China
- ProdList
- 961
- Advantage
- 65
- Tel
- 028-85114309 18982182443
- yangli@happysyn.com
- Country
- China
- ProdList
- 2151
- Advantage
- 55
- Tel
- 0531-81313138 13066006660
- Fax
- QQ: 3366077777
- chibapharm@foxmail.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 021-54880687
- Fax
- 021-54880687
- Country
- China
- ProdList
- 511
- Advantage
- 55
- Tel
- 021-20960837
- Fax
- 021-20960837
- market@aloespharm.com
- Country
- China
- ProdList
- 1302
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
- Tel
- 18957373295
- Fax
- -
- Country
- China
- ProdList
- 1580
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-20960837,QQ1332204249
- Fax
- 021-20960837
- sales@skychemical.com
- Country
- China
- ProdList
- 3341
- Advantage
- 55
- Tel
- 023-63225655 13320248848
- Fax
- 023-63225655QQ2366581735
- 2366581735@qq.com
- Country
- China
- ProdList
- 511
- Advantage
- 55
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 021-20242659 18930833303
- Fax
- +86 (21) 2024-2659
- Sales@changyanchem.cn
- Country
- China
- ProdList
- 5001
- Advantage
- 55
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 12475
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 13356901049
- Fax
- QQ：1025383091
- 3119594100@qq.com
- Country
- China
- ProdList
- 7964
- Advantage
- 55
- Tel
- 0512-50152853
- Fax
- 0512-50152853
- jjks1111@126.com
- Country
- China
- ProdList
- 623
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 13933818572
- Fax
- 0311-82870388
- 1519554262@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 15088289376
- 248775804@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 0751-2815688 13927872512
- Fax
- 0751-8963795
- 3007421951@qq.com
- Country
- China
- ProdList
- 9939
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- +86-27-8746-5837 +8619945049750
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9629
- Advantage
- 58
- Tel
- +86-25-58393656
- Fax
- +86-25-58393656
- sales@hengbeichem.cn
- Country
- China
- ProdList
- 6854
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- 0510-86838766 13636419861
- 2258830676@qq.com
- Country
- China
- ProdList
- 5044
- Advantage
- 58
- Tel
- 0371-63682289 15538176268
- Fax
- QQ：1875164801
- jacschem@163.com
- Country
- China
- ProdList
- 9926
- Advantage
- 58
- Tel
- +86 028-84641798 15982321820
- abby@arkpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 15151934985
- sales@yingsapharm.com
- Country
- China
- ProdList
- 5181
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
More
Less
View Lastest Price from 2,4-Dichloro-8-methoxyquinazoline manufacturers
Career Henan Chemical Co
- Product
- 2,4-Dichloro-8-methoxyquinazoline 61948-60-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30
61948-60-5, 2,4-Dichloro-8-methoxyquinazolineRelated Search:
Cefazolin sodium salt
Cefazolin
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Sulfaquinoxaline
Quinazoline
2,4-Dichloroquinazoline
Methoxy
2,4-Dichloro-8-methoxyquinazoline