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2-FLUORO-5-HYDROXYBENZOIC ACID

Product Name
2-FLUORO-5-HYDROXYBENZOIC ACID
CAS No.
51446-30-1
Chemical Name
2-FLUORO-5-HYDROXYBENZOIC ACID
Synonyms
3-Carboxy-4-fluorophenol;2-Fluoro-5-hydroxybenzoicaci;2-Fluro-5-Hydroxybenzoic Acid;2-fluoro-5-hydroxybenozicacid;2-FLUORO-5-HYDROXYBENZOIC ACID;Benzoic acid, 2-fluoro-5-hydroxy-
CBNumber
CB3151077
Molecular Formula
C7H5FO3
Formula Weight
156.11
MOL File
51446-30-1.mol
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2-FLUORO-5-HYDROXYBENZOIC ACID Property

Melting point:
201-203°C
Boiling point:
354.8±27.0 °C(Predicted)
Density 
1.492±0.06 g/cm3(Predicted)
storage temp. 
RT, stored under nitrogen
pka
3.15±0.10(Predicted)
form 
Powder
Appearance
White to off-white Solid
CAS DataBase Reference
51446-30-1(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
36/37/38-51-41-22
Safety Statements 
26-36-39
Hazard Note 
Corrosive
HazardClass 
IRRITANT
HS Code 
2918290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
F596048
Product name
2-Fluoro-5-hydroxybenzoicacid
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC9534
Product name
2-Fluoro-5-hydroxybenzoicacid
Packaging
1g
Price
$18
Updated
2021/12/16
SynQuest Laboratories
Product number
2629-3-10
Product name
2-Fluoro-5-hydroxybenzoic acid
Packaging
1g
Price
$20
Updated
2021/12/16
Apolloscientific
Product number
PC9534
Product name
2-Fluoro-5-hydroxybenzoicacid
Packaging
5g
Price
$30
Updated
2021/12/16
SynQuest Laboratories
Product number
2629-3-10
Product name
2-Fluoro-5-hydroxybenzoic acid
Packaging
5G
Price
$48
Updated
2021/12/16
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2-FLUORO-5-HYDROXYBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

off-white crytalline

Synthesis

1084801-91-1

51446-30-1

Step 1: Methyl 2-fluoro-5-hydroxybenzoate (30.0 g, 176.47 mmol, 1.0 eq.) was dissolved in a solvent mixture of THF and H2O (3:1 v/v, total 350 mL). To this solution was added LiOH-H2O (22.2 g, 529.41 mmol, 3.0 eq.) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, THF was removed by distillation under reduced pressure and the residue was diluted with cold water. The pH was adjusted to about 3 with 1.5 N HCl aqueous solution and the aqueous phase was extracted with EtOAc (3 x 250 mL). The organic phases were combined, washed with brine (150 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 2-fluoro-5-hydroxybenzoic acid as an off-white solid (25.1 g, 91% yield).MS m/z: [M-1]? = 155.4.

References

[1] Patent: WO2015/51043, 2015, A1. Location in patent: Paragraph 00248
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7818 - 7839

2-FLUORO-5-HYDROXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

4-Fluoroanisole Toluene Carbon dioxide Boron trifluoride diethyl etherate Tetrahydrofuran Diethyl ether Methanol Sodium hydroxide n-Butyllithium Citric acid

Preparation Products

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2-FLUORO-5-HYDROXYBENZOIC ACID Suppliers

China 132 Germany 6 India 7 Italy 1 The Netherlands 1 United Kingdom 16 United States 22 Global 185
P&S Chemicals
Tel
--
Fax
--
Email
info@pschemicals.com
Country
The Netherlands
ProdList
2724
Advantage
58
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View Lastest Price from 2-FLUORO-5-HYDROXYBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-FLUORO-5-HYDROXYBENZOIC ACID 51446-30-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

51446-30-1, 2-FLUORO-5-HYDROXYBENZOIC ACIDRelated Search:

2,6-DIFLUORO-3-METHOXYBENZOIC ACID 2,6-DIFLUORO-3-HYDROXYBENZOIC ACID 2-FLUORO-5-HYDROXYBENZOIC ACID 2-FLUORO-5-(TRIFLUOROMETHOXY)BENZOIC ACID 3-METHOXY-2,4,6-TRIFLUOROBENZOIC ACID 2-CHLORO-6-FLUORO-3-METHOXYBENZOIC ACID 5-FLUORO-2-HYDROXYBENZOIC ACID,5-Fluoro-2-hydroxybenzoic acid 97% 4-FLUORO-3-HYDROXYBENZOIC ACID 2-FLUORO-4-HYDROXYBENZOIC ACID 3-FLUORO-4-HYDROXYBENZOIC ACID 98%,3-FLUORO-4-HYDROXYBENZOIC ACID HYDRATE,3-FLUORO-4-HYDROXYBENZOIC ACID 4-Fluoro-2-Hydroxybenzoic Acid 2-Hydroxy-4-Fluoro Benzoic Acid,4-Fluoro-2-hydroxybenzoic acid 99%,4-FLUORO-2-HYDROXYBENZOIC ACID 2-Fluoro-6-hydroxybenzoic acid 97%,6-Fluoro-2-hydroxybenzoic acid,2-FLUORO-6-HYDROXYBENZOIC ACID 4-Fluoro-3-hydroxybenzoic Acid Methyl Ester 3-FLUORO-2-HYDROXYBENZOIC ACID,3-FLUORO-2-HYDROXYBENZOIC ACID(3-FLUOROSALICYLIC ACID) 2-FLUORO-5-METHOXYBENZOIC ACID 2,4-DIFLUORO-3,5-DIMETHOXY BENZOIC ACID 5-FLUORO-1,3-BENZODIOXOLE-4-CARBOXYLIC ACID 6-FLUORO-2,3-DIHYDROXYBENZOIC ACID

  • 2-FLUORO-5-HYDROXYBENZOIC ACID
  • 2-fluoro-5-hydroxybenozicacid
  • 3-Carboxy-4-fluorophenol
  • Benzoic acid, 2-fluoro-5-hydroxy-
  • 2-Fluoro-5-hydroxybenzoicaci
  • 2-Fluro-5-Hydroxybenzoic Acid
  • 51446-30-1
  • 51466-30-1
  • C14H8F2O5
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzoic acid
  • Acids & Esters
  • Fluorine Compounds
  • Phenols