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tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate

Product Name
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate
CAS No.
145166-06-9
Chemical Name
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate
Synonyms
-2-hydroxycyclohexyl);2S)-2-hydroxycyclohexyl]-;1S,S-Boc-2-aMinocyclohexanol;(1S,2S)-N-Boc-2-aminocyclohexanol;(1S,2S)-trans-N-Boc-2-Aminocyclohexanol;(1S,2S)-N-Boc-2-aminocyclohexanol,99%e.e.;tert-butyl (1S,2S)-2-hydroxycyclohexylcarbamate;ert-Butyl((1S,2S)-2-hydroxycyclohexyl)carbamate;tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate;tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate
CBNumber
CB31512710
Molecular Formula
C11H21NO3
Formula Weight
215.29
MOL File
145166-06-9.mol
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tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate Property

Boiling point:
337.7±31.0 °C(Predicted)
Density 
1.06±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
12.11±0.40(Predicted)
form 
solid
Appearance
White to off-white Solid
BRN 
5810950
InChI
InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9(8)13/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9-/m0/s1
InChIKey
XVROWZPERFUOCE-IUCAKERBSA-N
SMILES
C(OC(C)(C)C)(=O)N[C@H]1CCCC[C@@H]1O
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
670987
Product name
(1S,2S)-trans-N-Boc-2-aminocyclohexanol
Purity
95%
Packaging
1g
Price
$213
Updated
2022/05/15
American Custom Chemicals Corporation
Product number
CCH0000005
Product name
(1S,2S)-TRANS-N-BOC-2-AMINOCYCLOHEXANOL
Purity
95.00%
Packaging
1G
Price
$225.76
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140509
Product name
tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate
Packaging
5G
Price
$324
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140509
Product name
tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate
Packaging
500mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
Z4169
Product name
tert-Butyl((1S,2S)-2-hydroxycyclohexyl)carbamate
Packaging
250mg
Price
$92
Updated
2021/12/16
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tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate Chemical Properties,Usage,Production

Synthesis

764659-69-0

121282-70-0

General procedure for the synthesis of trans-N-Boc-cyclohexylamino alcohols from the compounds (CAS: 764659-69-0): the product of part A (8.0 g, 26.2 mmol) was dissolved in a solvent mixture of cyclohexene (100 mL) and ethanol (150 mL), and palladium/carbon catalyst (2.0 g) was added. The reaction mixture was heated to reflux for 6 h. Upon completion of the reaction, the catalyst was removed by filtration through a Celite pad. The filtrate was concentrated to afford tert-butyl (1S,2S)-2-hydroxy-cyclohexyl-carbamate (5.7 g, 100% yield) as a white solid. Mass spectral analysis showed M/Z 216.2 ([M + H]+).

References

[1] Patent: WO2004/83174, 2004, A2. Location in patent: Page 172
[2] Patent: WO2005/87731, 2005, A1. Location in patent: Page/Page column 321
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4419 - 4427
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132

tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate Suppliers

China 79 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 89
Energy Chemical
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View Lastest Price from tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate manufacturers

Career Henan Chemical Co
Product
tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate 145166-06-9
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

145166-06-9, tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamateRelated Search:

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  • tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate
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  • (1S,2S)-trans-N-Boc-2-Aminocyclohexanol
  • tert-butyl (1S,2S)-2-hydroxycyclohexylcarbamate
  • 2S)-2-hydroxycyclohexyl]-
  • 1S,S-Boc-2-aMinocyclohexanol
  • CarbaMic acid, N-[(1S,2S)-2-hydroxycyclohexyl]-, 1,1-diMethylethyl ester
  • tert-butyl N-[(1S,2S)-2-hydroxycyclohexyl]carbamate
  • (1S,2S)-N-Boc-2-aminocyclohexanol
  • -2-hydroxycyclohexyl)
  • (1S,2S)-N-Boc-2-aminocyclohexanol,99%e.e.
  • ert-Butyl((1S,2S)-2-hydroxycyclohexyl)carbamate
  • tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate USP/EP/BP
  • (1<i>S</i>,2<i>S</i>)-<i>trans</i>-<i>N-</i>Boc-2-aminocyclohexanol
  • 145166-06-9
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