TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE
CAS No.: 167263-04-9
Chemical Name: TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE
Synonyms: tert-Butyl 4-cyano-4-(pyridin-2-yl);1-Boc-4-cyano-4-(2-pyridinyl)-piperidine;TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE;1,1-Dimethylethyl 4-cyano-4-(2-pyridinyl)-1-piperidinecarboxylate;1-Piperidinecarboxylic acid, 4-cyano-4-(2-pyridinyl)-, 1,1-diMethylethyl ester
CBNumber: CB82458326
Molecular Formula: C16H21N3O2
Formula Weight: 287.36
MOL File: 167263-04-9.mol

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TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE Property

Boiling point:: 444.6±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.43±0.19(Predicted)
InChI: InChI=1S/C16H21N3O2/c1-15(2,3)21-14(20)19-10-7-16(12-17,8-11-19)13-6-4-5-9-18-13/h4-6,9H,7-8,10-11H2,1-3H3
InChIKey: OUILGYJQVAMETA-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C#N)(C2=NC=CC=C2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: 8519AA
Product name: Benzyl(2-((2-amino-4-methoxyphenyl)(phenyl)amino)-2-oxoethyl)carbamate
Packaging: 100mg
Price: $169
Updated: 2021/12/16

AK Scientific

Product number: 8519AA
Product name: Benzyl(2-((2-amino-4-methoxyphenyl)(phenyl)amino)-2-oxoethyl)carbamate
Packaging: 250mg
Price: $239
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391854
Product name: BENZYL-(2-((2-AMINO-4-METHOXYPHENYL)(PHENYL)AMINO)-2-OXOETHYL)CARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $496.52
Updated: 2021/12/16

Matrix Scientific

Product number: 126995
Product name: tert-Butyl4-cyano-4-(pyridin-2-yl)piperidine-1-carboxylate
Purity: >97%
Packaging: 1g
Price: $630
Updated: 2021/12/16

Ambeed

Product number: A484839
Product name: tert-Butyl4-cyano-4-(pyridin-2-yl)piperidine-1-carboxylate
Purity: 96%
Packaging: 5g
Price: $792
Updated: 2021/12/16

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TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

2739-97-1

118753-70-1

167263-04-9

Sodium hydride (60% dispersed in mineral oil, 2.04 g, 51 mmol) was added in batches to a stirred solution of 2-pyridineacetonitrile (1.8 mL, 17 mmol) and tert-butyl N,N-bis(2-chloroethyl)carbamate (in appropriate amounts) in anhydrous DMF (50 mL) under nitrogen protection, and the temperature of the reaction was maintained at 0°C. The reaction was carried out in a controlled manner. The addition process was controlled to be completed within 8 min. Subsequently, the reaction system was warmed up to 60 °C and the reaction was continuously stirred for 5.5 hours. After completion of the reaction, the mixture was cooled to room temperature, extracted with ethyl acetate (4 x 150 mL), the organic phases were combined and washed with water (3 x 200 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give a red to black oily crude product. The crude product was adsorbed on silica gel and purified by column chromatography with the eluent being an isohexane solution of 20% ethyl acetate to give tert-butyl 4-cyano-4-(pyridin-2-yl)piperidine-1-carboxylate as an orange solid (2.13 g, 44% yield). The structure of the product was confirmed by 1H NMR (360 MHz, CDCl3): δ 1.48 (9H, s), 2.04-2.08 (2H, m), 2.17-2.25 (2H, m), 3.15-3.28 (2H, m), 4.20-4.35 (2H, m), 7.25-7.29 (1H, m), 7.61 (1H, d, J = 8 Hz), 7.73-7.78 (1H, m), 8.61 (1H, dd, J = 0.7, 3.9 Hz). The mass spectrum (MS) showed [M+H]+ m/z = 287 (corresponding to the loss of the tert-butyl fragment, -56).

References

[1] Patent: WO2005/51390, 2005, A1. Location in patent: Page/Page column 28
[2] Bioorganic and medicinal chemistry letters, 2000, vol. 10, # 15, p. 1625 - 1628
[3] Patent: US5635510, 1997, A
[4] Patent: US5824690, 1998, A

TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE Suppliers

China 23 India 1 United States 4 Global 28

Liaocheng Jinge Synthetic Material CO.,LTD.

Tel: 0635-2121866 18365825121
Email: y18365825121@163.com
Country: China
ProdList: 110
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Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
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Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
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SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
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Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

BioPharmaMatrix,Inc.

Tel: 0510-86010668
Fax: 0510-86010668
Email: sales@biopharmamatrix.com
Country: China
ProdList: 4739
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
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Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
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View Lastest Price from TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE 167263-04-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1ton
Release date: 2020-01-08

167263-04-9, TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATERelated Search:

tert-Butyl 4-bromobutanoate 5-BROMO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate tert-Butyl 2,6-dichloroisonicotinate tert-Butyl methacrylate tert-Butyl N-((2S,1S)-2-hydroxycyclohexyl)carbamate TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE TERT-BUTYL 4-OXO-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate

1-Boc-4-cyano-4-(2-pyridinyl)-piperidine

tert-Butyl 4-cyano-4-(pyridin-2-yl)

TERT-BUTYL 4-CYANO-4-(PYRIDIN-2-YL)PIPERIDINE-1-CARBOXYLATE

1-Piperidinecarboxylic acid, 4-cyano-4-(2-pyridinyl)-, 1,1-diMethylethyl ester

1,1-Dimethylethyl 4-cyano-4-(2-pyridinyl)-1-piperidinecarboxylate

167263-04-9