H-SER-PHE-LEU-LEU-ARG-OH
- Product Name
- H-SER-PHE-LEU-LEU-ARG-OH
- CAS No.
- 141685-53-2
- Chemical Name
- H-SER-PHE-LEU-LEU-ARG-OH
- Synonyms
- SFLLR;SER-PHE-LEU-LEU-ARG;H-SER-PHE-LEU-LEU-ARG-OH;Thrombin Receptor Activator for Peptide 5 (TRAP-5);L-Seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginine;L-Arginine, L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-;SFLLR, Coagulation Factor II Receptor (1-5) (huMan), PAR-1 (1-5) (huMan), ThroMbin Receptor (1-5) (huMan), ThroMbin Receptor Activator Peptide 5, Proteinase Activated Receptor 1 (1-5) (huMan)
- CBNumber
- CB3151835
- Molecular Formula
- C30H50N8O7
- Formula Weight
- 634.77
- MOL File
- 141685-53-2.mol
H-SER-PHE-LEU-LEU-ARG-OH Property
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- insoluble in EtOH; ≥14.63 mg/mL in H2O; ≥63.5 mg/mL in DMSO
- form
- solid
- pka
- 3.34±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A1036
- Product name
- ThrombinReceptorActivatorforPeptide5(TRAP-5)
- Packaging
- 5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A1036
- Product name
- ThrombinReceptorActivatorforPeptide5(TRAP-5)
- Packaging
- 10mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0044800
- Product name
- ThrombinReceptorActivatorforPeptide5TRAP-5
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- A1036
- Product name
- ThrombinReceptorActivatorforPeptide5(TRAP-5)
- Packaging
- 25mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CS-0044800
- Product name
- ThrombinReceptorActivatorforPeptide5TRAP-5
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
H-SER-PHE-LEU-LEU-ARG-OH Chemical Properties,Usage,Production
Biological Activity
thrombin receptor activator for peptide 5 (trap-5),(c30h50n8o7), a peptide with the sequence nh2-ser-phe-leu-leu-arg-cooh, mw= 634.76. coagulation factor ii (thrombin) receptor is a g protein-coupled receptor involved in the regulation of thrombotic response. proteolytic cleavage leads to the activation of the receptor(1). thrombin signalling in platelets contributes to hemostasis and thrombosis. endothelial pars participate in the regulation of vascular tone and permeability while in vascular smooth muscle they mediate contraction, proliferation, and hypertrophy. pars contribute to the pro-inflammatory response observed in atherosclerosis and restenosis. recent research has also implicated these novel receptors in muscle growth and bone cell differentiation and proliferation(2). in t cells, activation of par1, par2 and par3 induce tyrosine phosphorylation of vav1. activation of pars also led to an increase in tyrosine phosphorylation of zap-70 and slp-76, two key proteins in t cell receptor (tcr) signalling(3).figure1 formula of thrombin receptor activator for peptide 5 (trap-5)figure2 structure of thrombin receptor
References
1. Bahou WF, Nierman WC, Durkin AS, Potter CL, Demetrick DJ (September 1993). "Chromosomal assignment of the human thrombin receptor gene: localization to region q13 of chromosome 5". Blood 82 (5): 1532–7.2. Martorell L, Martínez-González J, Rodríguez C, Gentile M, Calvayrac O, Badimon L (February 2008). "Thrombin and protease-activated receptors (PARs) in atherothrombosis". Thromb. Haemost. 99 (2): 305–15.3. Bar-Shavit R, Maoz M, Yongjun Y, Groysman M, Dekel I, Katzav S (January 2002). "Signalling pathways induced by protease-activated receptors and integrins in T cells". Immunology 105 (1): 35–46.
H-SER-PHE-LEU-LEU-ARG-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-SER-PHE-LEU-LEU-ARG-OH Suppliers
- Tel
- --
- Fax
- --
- sales@chemcube.eu
- Country
- Germany
- ProdList
- 4083
- Advantage
- 34
View Lastest Price from H-SER-PHE-LEU-LEU-ARG-OH manufacturers
- Product
- H-SER-PHE-LEU-LEU-ARG-OH 141685-53-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- H-SER-PHE-LEU-LEU-ARG-OH 141685-53-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13