Elesclomol

ChemicalBook > CAS DataBase List > Elesclomol

Product Name: Elesclomol
CAS No.: 488832-69-5
Chemical Name: Elesclomol
Synonyms: CS-482;STA-4783;elesclomol;STA-4783;STA4783;Elesclomol USP/EP/BP;ElescloMol (STA-4783);Enzastaurin Impurity 6;N'1,N'3-Dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide;N1',N3'-dimethyl-N1',N3'-di(phenylcarbonothioyl)malonohydrazide;1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid
CBNumber: CB31518510
Molecular Formula: C19H20N4O2S2
Formula Weight: 400.52
MOL File: 488832-69-5.mol

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Elesclomol Property

Density: 1.313
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥20.15 mg/mL in DMSO; ≥5.68 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 7.99±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2651
Product name: Elesclomol
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $97.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2651
Product name: Elesclomol
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $395
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0005195
Product name: ELESCLOMOL
Purity: 95.00%
Packaging: 1MG
Price: $603.95
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180784
Product name: Elesclomol (STA-4783)
Purity: >98%
Packaging: 100mg
Price: $690.2
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE157996
Product name: Elesclomol
Packaging: 50mg
Price: $270
Updated: 2021/12/16

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Elesclomol Chemical Properties,Usage,Production

Definition

ChEBI: A carbohydrazide obtained by formal condensation of the carboxy groups of malonic acid with the hydrino groups of two molar equivalents of N-methylbenzenecarbothiohydrazide

Biological Activity

elesclomol (also known as sta-4783), originally identified in a cell-based phenotypic screen for proapoptotic activity, is a novel small-molecule that potently induces apoptosis of cancer cells through the rapid generation of reactive oxygen species (ros) and the induction of unmanageable levels of oxidative stress. elesclomol exhibits autitumor activity against a broad spectrum of types of cancer cell in human tumor xengograft models due to its excessive ros production and elevated levels of oxidative stress leading to the death of cancer cells. elesclomol is currently being studies as a novel cancer therapeutic, in which it has demonstrated ability to prolong progression-free survival in study subjects.ronald k. blackman, kahlin cheung-ong, marinella gebbia, david a. proia, suqin he, jane kepros, aurelie jonneaux, philippe marchetti, jerome kluza, patricia e. rao, yumiko wada, guri giaever, corey nislow. mitochondrial electron transport is the cellular target of the oncology drug elesclomol. plos one 2012; 7(1): e29798jessica r. kirshner, suqin he, vishwasenani balasubramanyam, jane kepros, chin-yu yang, mei zhang, zhenjian du, james barsoum, and john bertin. elesclomol induces cancer cell apoptosis through oxidative stress. mol cancer ther 2008; 7:2319-2327

target

HSP70

Elesclomol Preparation Products And Raw materials

Raw materials

Preparation Products

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488832-69-5, ElesclomolRelated Search:

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elescloMol, N'1,N'3-diMethyl-N'1,N'3-di(phenylcarbonothioyl)Malonohydrazide

elesclomol

1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid

STA-4783

ElescloMol (STA-4783)

N1',N3'-dimethyl-N1',N3'-di(phenylcarbonothioyl)malonohydrazide

STA-4783;STA4783

CS-482

Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

Elesclomol USP/EP/BP

N'1,N'3-Dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide

Enzastaurin Impurity 6

488832-69-5

Inhibitors

APIs