CA-074 ME

Product Name: CA-074 ME
CAS No.: 147859-80-1
Chemical Name: CA-074 ME
Synonyms: CA-074 ME;CA-074(OME);CA-074 methyl ester;CATHEPSIN B INHIBITOR IV;CA-074Me/CA-074 methyl ester;CA-074 methyl ester (CA-074 Me);L-trans-Epoxysuccinyl(propylamide)-Ile-P;(L-3-Trans-(propylcarbamoyl)oxirane-2-carbony;L-TRANS-EPOXYSUCCINYL-ILE-PRO-OME PROPYLAMIDE;L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OME
CBNumber: CB3152175
Molecular Formula: C19H31N3O6
Formula Weight: 397.47
MOL File: 147859-80-1.mol

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CA-074 ME Property

Melting point:: 153-155°C
Boiling point:: 666.3±55.0 °C(Predicted)
Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 13.38±0.40(Predicted)
form: Solid
color: White to Off-White
InChIKey: XGWSRLSPWIEMLQ-YTFOTSKYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5857
Product name: CA-074 methyl ester
Purity: ≥99% (TLC)
Packaging: 5mg
Price: $440
Updated: 2024/03/01

Sigma-Aldrich

Product number: 205531
Product name: CA-074 Me
Purity: CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
Packaging: 1MG
Price: $272
Updated: 2024/03/01

Alfa Aesar

Product number: J64737
Product name: Cathepsin B Inhibitor IV
Packaging: 10mg
Price: $602
Updated: 2023/06/20

Cayman Chemical

Product number: 18469
Product name: CA-074 methyl ester
Purity: ≥98%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 18469
Product name: CA-074 methyl ester
Purity: ≥98%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

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CA-074 ME Chemical Properties,Usage,Production

Uses

CA-074 methyl ester is a cell-permeable cathepsin B inhibitor.

Uses

CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells and human pancreatic cancer PANC-1 cells.

Biological Activity

ca-074 me is a membrane-permeable and selective inhibitor of cathepsin b with ic50 value of 36.3 nm [1, 2].ca-074 me is a methyl ester derivative of ca-074. in cultured human gingival fibroblasts, ca-074 me exerted a 95% inhibition of cathepsin b and partial inhibition (54%) of the combined activities of cathepsins b and l. ca-074 me was also found to inhibit cathespin l under reducing conditions. it inhibited the activity of purified human cathepsin l by more than 90% when the enzyme had been pre-incubated with 1.4 mm dtt or 4.2 mm gsh for 2 hours. besides that, ca-074 me completely inhibited cathepsin b in the presence of 1.4 mm dtt [2, 3].

Biochem/physiol Actions

CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.

target

cathepsin B

References

[1] wu x, zhang l, gurley e, et al. prevention of free fatty acid–induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways. hepatology, 2008, 47(6): 1905-1915.
[2] steverding d. the cathepsin b-selective inhibitors ca-074 and ca-074me inactivate cathepsin l under reducing conditions. open enzyme inhibition journal, 2011, 4: 11-16.
[3] buttle d j, murata m, knight c g, et al. ca074 methyl ester: a proinhibitor for intracellular cathepsin b. archives of biochemistry and biophysics, 1992, 299(2): 377-380.

CA-074 ME Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-074 ME Suppliers

China 90 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 22 USA 1 Global 118

AdooQ BioScience, LLC

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View Lastest Price from CA-074 ME manufacturers

Career Henan Chemical Co

Product: CA-074 ME 147859-80-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-23

147859-80-1, CA-074 MERelated Search:

Succinic acid N-ACETYLLACTOSAMINE Disodium succinate 5 MG CA-074INHIBITOR FOR CATHEPSIN B 5 MG CA-074 ME, PROINH. FOR INTRACELLULARCATHEPSIN B MEMBRANE-PERMEABLE ANALOG OF CA-074 CA-074 METHYL ESTER METHYL 1-ETHYLPYRROLIDINE-2-CARBOXYLATE H-VAL-PRO-OH HCL AC-PRO-OME CA-074 CA-074 ME

N-(L-3-TRANS-PROPYLCARBONYL-OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE METHYL ESTER

L-trans-Epoxysuccinyl(propylamide)-Ile-P

(L-3-Trans-(propylcarbamoyl)oxirane-2-carbony

L-trans-Epoxysuccinic Ile-Pro-OMe Propylamide

L-trans-Epoxysuccinyl-isoleucyl-proline methyl ester propylamide

CA-074 methyl ester

(L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester

CA-074(OME)

(S)-Methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)p

L-TRANS-EPOXYSUCCINYL-ILE-PRO-OME PROPYLAMIDE

L-TRANS-EPOXYSUCCINYL (PROPYLAMIDE)-ILE-PRO-OME

CA-074 ME

CATHEPSIN B INHIBITOR IV

[L-3-TRANS-(POLYCARBAMOYL)OXIRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE METHYL ESTER

(L-3-TRANS-(PROPYLCARBAMOYL)OXIRANE-2-CARBONYL)-L-ISOLEUCYL-L-PROLINE METHYL ESTER

[L-3-TRANS-(PROPYLCARBAMOYL)OXYRANE-2-CARBONYL]-L-ISOLEUCYL-L-PROLINE METHYL ESTER

N-((L-3-TRANS-(PROPYLAMINO)CARBONYL)-OXIRANE-2-CARBONYL)-ILE-PRO-OME

L-trans-Epoxysuccinyl(propylaMide)-Ile-Pro-OMe, CA-074Me, N-(L-3-trans-(PropylaMino)carbonyl)-oxirane-2-carbonyl)-Ile-Pro-OMe

(S)-Methyl 1-((2S,3S)-3-methyl-2-((2S,3S)-3-(propylcarbamoyl)oxirane-2-carboxamido)pentanoyl)pyrrolidine-2-carboxylate

CA-074 methyl ester (CA-074 Me)

L-Proline, N-[[(2S,3S)-3-[(propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-, methyl ester

CA-074Me/CA-074 methyl ester

Methyl ((2S,3S)-3-(propylcarbamoyl)oxirane-2-carbonyl)-L-isoleucyl-L-prolinate

147859-80-1

peptides

Pepetides