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TALIPEXOLE

Product Name
TALIPEXOLE
CAS No.
101626-70-4
Chemical Name
TALIPEXOLE
Synonyms
Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
CBNumber
CB3153213
Molecular Formula
C10H15N3S
Formula Weight
209.31
MOL File
101626-70-4.mol
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TALIPEXOLE Property

Boiling point:
364.6±37.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
7.22±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
5MG
Price
$490
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
10MG
Price
$520
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
50MG
Price
$920
Updated
2021/12/16
AvaChem
Product number
2567B
Product name
Talipexole
Packaging
1g
Price
$2900
Updated
2021/12/16
Crysdot
Product number
CD31004840
Product name
Talipexole
Purity
98+%
Packaging
5mg
Price
$76
Updated
2021/12/16
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TALIPEXOLE Chemical Properties,Usage,Production

Description

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

Definition

ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.

brand name

Domin

TALIPEXOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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TALIPEXOLE Suppliers

China 19 Europe 2 Germany 1 United Kingdom 4 United States 12 Global 38
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4600
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
16621358918
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9208
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
10035
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
17691182729 15529505138
Email
1021@dideu.com
Country
China
ProdList
9969
Advantage
58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
Advantage
58
Shanghai Qiming Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6502
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6748
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Lanospharma Laboratories Co.,Ltd
Tel
--
Fax
--
Email
sales@lanospharma.com
Country
China
ProdList
6329
Advantage
56
Shanghai New Union Textra Import & Export Co., Ltd
Tel
--
Fax
--
Email
zhou@pharmchemical.com
Country
China
ProdList
2748
Advantage
60

101626-70-4, TALIPEXOLERelated Search:

ARANIDIPINE Bendamustine Donepezil CALYXOL ISO-TALIPEXOLE, DIHYDROCHLORIDE TALIPEXOLE DIDHYDROCHLORIDE,Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride,talipexole hydrochloride 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE TALIPEXOLE 2-(THIAZOL-4-YL)ETHYLAMINE AMTHAMINE DIHYDROBROMIDE 5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE

  • TALIPEXOLE
  • 5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
  • Domin
  • 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
  • 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
  • Talipexol
  • Talipexol [spanish]
  • Talipexolum
  • Talipexolum [latin]
  • 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
  • TALIPEXOLE USP/EP/BP
  • 6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
  • 101626-70-4