ChemicalBook > CAS DataBase List > TALIPEXOLE

TALIPEXOLE

Product Name
TALIPEXOLE
CAS No.
101626-70-4
Chemical Name
TALIPEXOLE
Synonyms
Domin;Talipexol;TALIPEXOLE;Talipexolum;Talipexolum [latin];Talipexol [spanish];TALIPEXOLE USP/EP/BP;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
CBNumber
CB3153213
Molecular Formula
C10H15N3S
Formula Weight
209.31
MOL File
101626-70-4.mol
More
Less

TALIPEXOLE Property

Boiling point:
364.6±37.0 °C(Predicted)
Density 
1.167±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
7.22±0.20(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
5MG
Price
$490
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
10MG
Price
$520
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009175
Product name
TALIPEXOLE
Purity
95.00%
Packaging
50MG
Price
$920
Updated
2021/12/16
AvaChem
Product number
2567B
Product name
Talipexole
Packaging
1g
Price
$2900
Updated
2021/12/16
Crysdot
Product number
CD31004840
Product name
Talipexole
Purity
98+%
Packaging
5mg
Price
$76
Updated
2021/12/16
More
Less

TALIPEXOLE Chemical Properties,Usage,Production

Description

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

Definition

ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.

brand name

Domin

TALIPEXOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TALIPEXOLE Suppliers

China 19 Europe 2 Germany 1 United Kingdom 4 United States 9 Global 35

101626-70-4, TALIPEXOLERelated Search:

ARANIDIPINE Bendamustine Donepezil CALYXOL ISO-TALIPEXOLE, DIHYDROCHLORIDE TALIPEXOLE DIDHYDROCHLORIDE,Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride,talipexole hydrochloride 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE TALIPEXOLE 2-(THIAZOL-4-YL)ETHYLAMINE AMTHAMINE DIHYDROBROMIDE 5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE

  • TALIPEXOLE
  • 5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
  • Domin
  • 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
  • 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
  • Talipexol
  • Talipexol [spanish]
  • Talipexolum
  • Talipexolum [latin]
  • 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
  • TALIPEXOLE USP/EP/BP
  • 6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
  • 101626-70-4