ChemicalBook > CAS DataBase List > 2-cyano-2-methylpropanoic acid

2-cyano-2-methylpropanoic acid

Product Name
2-cyano-2-methylpropanoic acid
CAS No.
22426-30-8
Chemical Name
2-cyano-2-methylpropanoic acid
Synonyms
2-Cyanoisobutyric acid;2-Cyano-2-methylpropanoicaci;2-Cyano-2-methylpropionic acid;2-cyano-2-methylpropanoic acid;2-cyano-2,2-dimethylacetic acid;Propanoic acid, 2-cyano-2-methyl-;2-Cyano-2,2-dimethylaceticacid,95%
CBNumber
CB31540982
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
22426-30-8.mol
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2-cyano-2-methylpropanoic acid Property

Melting point:
153-155°
Boiling point:
132-135℃/12mm
Density 
1.141±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
form 
Crystalline Solid
pka
pKa: 2.422(25°C)
color 
White
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C5H7NO2/c1-5(2,3-6)4(7)8/h1-2H3,(H,7,8)
InChIKey
DZDVNAVPCCNJRK-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C#N)(C)C
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Safety

HazardClass 
IRRITANT
HazardClass 
8
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C998783
Product name
2-Cyano-2-methylpropanoicacid
Packaging
500mg
Price
$175
Updated
2021/12/16
AK Scientific
Product number
1332AB
Product name
2-Cyano-2-methylpropanoicacid
Packaging
1g
Price
$224
Updated
2021/12/16
Apolloscientific
Product number
OR908203
Product name
2-Cyano-2,2-dimethylaceticacid
Purity
98%
Packaging
1g
Price
$232
Updated
2021/12/16
Matrix Scientific
Product number
046787
Product name
2-Cyano-2-methylpropanoic acid
Purity
95+%
Packaging
1g
Price
$129
Updated
2021/12/16
Matrix Scientific
Product number
046787
Product name
2-Cyano-2-methylpropanoic acid
Purity
95+%
Packaging
500mg
Price
$92
Updated
2021/12/16
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2-cyano-2-methylpropanoic acid Chemical Properties,Usage,Production

Synthesis

1572-98-1

22426-30-8

Preparation of Example A4-3: 2-cyano-2-methylpropionyl chloride; To a solution of commercially available ethyl 2-cyano-2-methylpropionate (3.5 g, 24.8 mmol) in methanol (10 ml) was added lithium hydroxide (LiOH, 900 mg, 37.2 mmol) and water (0.5 ml) and the reaction was stirred for 1 hour at 37°C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent, followed by acidification by addition of 1N hydrochloric acid (HCl, 50 ml) and extraction with ethyl acetate (EtOAc). The combined organic layers were dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 2-cyano-2-methylpropionic acid (2.67 g, 95% yield). The compound (2.5 g, 22 mmol) was dissolved in dichloromethane (DCM, 7 ml) and the reaction was carried out as described in Step B of Preparation Example A4-1, resulting in the target product 2-cyano-2-methylpropionyl chloride (2.5 g, 86.3% yield).

References

[1] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 30-31
[2] Synthesis, 2005, # 4, p. 569 - 574
[3] Patent: US2018/282328, 2018, A1. Location in patent: Paragraph 0832; 0833
[4] Chemische Berichte, 1932, vol. 65, p. 432,441
[5] Journal of the American Chemical Society, 1916, vol. 38, p. 911

2-cyano-2-methylpropanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-cyano-2-methylpropanoic acid manufacturers

Wuhan Konberd Biotech Co., Ltd
Product
2-Cyano-2-methylpropanoic Acid 22426-30-8
Price
US $1.00-1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10 tons
Release date
2025-03-13
Career Henan Chemical Co
Product
2-cyano-2-methylpropanoic acid 22426-30-8
Price
US $1.00/g
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-09

22426-30-8, 2-cyano-2-methylpropanoic acidRelated Search:

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  • 2-cyano-2-methylpropanoic acid
  • 2-Cyano-2-methylpropionic acid
  • 2-Cyanoisobutyric acid
  • 2-cyano-2,2-dimethylacetic acid
  • Propanoic acid, 2-cyano-2-methyl-
  • 2-Cyano-2,2-dimethylaceticacid,95%
  • 2-Cyano-2-methylpropanoicaci
  • 22426-30-8