2-cyano-2-methylpropanoic acid
- Product Name
- 2-cyano-2-methylpropanoic acid
- CAS No.
- 22426-30-8
- Chemical Name
- 2-cyano-2-methylpropanoic acid
- Synonyms
- 2-Cyanoisobutyric acid;2-Cyano-2-methylpropanoicaci;2-Cyano-2-methylpropionic acid;2-cyano-2-methylpropanoic acid;2-cyano-2,2-dimethylacetic acid;Propanoic acid, 2-cyano-2-methyl-;2-Cyano-2,2-dimethylaceticacid,95%
- CBNumber
- CB31540982
- Molecular Formula
- C5H7NO2
- Formula Weight
- 113.11
- MOL File
- 22426-30-8.mol
2-cyano-2-methylpropanoic acid Property
- Melting point:
- 153-155°
- Boiling point:
- 132-135℃/12mm
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- form
- Crystalline Solid
- pka
- pKa: 2.422(25°C)
- color
- White
- Sensitive
- Moisture Sensitive
- InChI
- InChI=1S/C5H7NO2/c1-5(2,3-6)4(7)8/h1-2H3,(H,7,8)
- InChIKey
- DZDVNAVPCCNJRK-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C#N)(C)C
Safety
- HazardClass
- IRRITANT
- HazardClass
- 8
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H332Harmful if inhaled
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C998783
- Product name
- 2-Cyano-2-methylpropanoicacid
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 046787
- Product name
- 2-Cyano-2-methylpropanoic acid
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- 046787
- Product name
- 2-Cyano-2-methylpropanoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $129
- Updated
- 2021/12/16
- Product number
- 1332AB
- Product name
- 2-Cyano-2-methylpropanoicacid
- Packaging
- 1g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- OR908203
- Product name
- 2-Cyano-2,2-dimethylaceticacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $232
- Updated
- 2021/12/16
2-cyano-2-methylpropanoic acid Chemical Properties,Usage,Production
Synthesis
1572-98-1
22426-30-8
Preparation of Example A4-3: 2-cyano-2-methylpropionyl chloride; To a solution of commercially available ethyl 2-cyano-2-methylpropionate (3.5 g, 24.8 mmol) in methanol (10 ml) was added lithium hydroxide (LiOH, 900 mg, 37.2 mmol) and water (0.5 ml) and the reaction was stirred for 1 hour at 37°C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent, followed by acidification by addition of 1N hydrochloric acid (HCl, 50 ml) and extraction with ethyl acetate (EtOAc). The combined organic layers were dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give 2-cyano-2-methylpropionic acid (2.67 g, 95% yield). The compound (2.5 g, 22 mmol) was dissolved in dichloromethane (DCM, 7 ml) and the reaction was carried out as described in Step B of Preparation Example A4-1, resulting in the target product 2-cyano-2-methylpropionyl chloride (2.5 g, 86.3% yield).
References
[1] Patent: WO2008/7930, 2008, A1. Location in patent: Page/Page column 30-31
[2] Synthesis, 2005, # 4, p. 569 - 574
[3] Patent: US2018/282328, 2018, A1. Location in patent: Paragraph 0832; 0833
[4] Chemische Berichte, 1932, vol. 65, p. 432,441
[5] Journal of the American Chemical Society, 1916, vol. 38, p. 911
2-cyano-2-methylpropanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-cyano-2-methylpropanoic acid Suppliers
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- Country
- India
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View Lastest Price from 2-cyano-2-methylpropanoic acid manufacturers
- Product
- 2-Cyano-2-methylpropanoic Acid 22426-30-8
- Price
- US $1.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10 tons
- Release date
- 2025-03-13
- Product
- 2-cyano-2-methylpropanoic acid 22426-30-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09