1-Cyano-1-cyclopropanecarboxylic acid
- Product Name
- 1-Cyano-1-cyclopropanecarboxylic acid
- CAS No.
- 6914-79-0
- Chemical Name
- 1-Cyano-1-cyclopropanecarboxylic acid
- Synonyms
- 1-Cyanocyclopropane-1-carboxylic acid;1-CYANOCYCLOPROPANECARBOXYLIC ACID;TIMTEC-BB SBB006670;2-CYANO-2-CYCLOPROPYLACETIC ACID;1-CYANO-1-CYCLOPROPAN CARBOXYLICACID;1-Cyanocycllopropanecarboxylic Acid;1-CYANO-1-CYCLOPROPANECARBOXYLIC ACID;Cyclopropanecarboxylic acid, 1-cyano-;1-Cyano-1-cyclopropanecarboxylic acid 97%;1-CYANO-1-CYCLOPROPANECARBOXYLIC ACID, 9 7%
- CBNumber
- CB7271520
- Molecular Formula
- C5H5NO2
- Formula Weight
- 111.1
- MOL File
- 6914-79-0.mol
1-Cyano-1-cyclopropanecarboxylic acid Property
- Melting point:
- 140 °C (lit.)
- Boiling point:
- 142 °C
- Density
- 1.3113 (rough estimate)
- refractive index
- 1.4260 (estimate)
- storage temp.
- 2-8°C
- pka
- 2.31±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 6914-79-0(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 20/21/22-34
- Safety Statements
- 26-27-36/37/39-45-25
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 343390
- Product name
- 1-Cyano-1-cyclopropanecarboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- C3490
- Product name
- 1-Cyanocyclopropanecarboxylic Acid
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $57
- Updated
- 2025/07/31
- Product number
- C3490
- Product name
- 1-Cyanocyclopropanecarboxylic Acid
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $170
- Updated
- 2025/07/31
- Product number
- 409547
- Product name
- 1-Cyano-1-cyclopropanecarboxylic acid
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- C962603
- Product name
- 1-Cyano-1-cyclopropanecarboxylic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
1-Cyano-1-cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light brown crystalline powder
Uses
1-Cyano-1-cyclopropanecarboxylic acid may be used in the synthesis of amidine-based nanomolar sphingosine kinase1 subtype-selective inhibitors.
Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 2969, 1975 DOI: 10.1021/jo00908a030
General Description
1-Cyano-1-cyclopropanecarboxylic acid (1-Cyanocyclopropanecarboxylic acid) is a substituted cyclopropane. It is the intermediate formed during homoconjugate addition of nucleophiles to cyclopropane-1,1-dicarboxylate derivative.
Synthesis
6914-73-4
6914-79-0
General procedure for the synthesis of 1-cyano-1-cyclopropanecarboxylic acid from methyl 1-cyanocyclopropanecarboxylate: KOH (13.78 g, 85%, 209 mmol) was dissolved in 80 mL of ethanol, and then this solution was added to a 100 mL ethanol solution of methyl 1-cyano-1-cyclopropanecarboxylate (25.64 g, 205 mmol), and the reaction was stirred for 1 hour. After completion of the reaction, the mixture was evaporated and concentrated, dissolved in 200 mL of water and the aqueous phase was washed with 30 mL of chloroform. Subsequently, the aqueous phase was acidified with hydrochloric acid to pH=1. 30 g of NaCl was added to the acidified mixture, followed by 6 extractions with 50 mL of chloroform. All organic layers were combined, dried with anhydrous MgSO4 and finally the solvent was evaporated under vacuum to afford the target product 1-cyano-1-cyclopropanecarboxylic acid (20.60 g, 90% yield). The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 1.73 (m, 4H), 11.08 (s, 1H).
References
[1] Tetrahedron, 2013, vol. 69, # 16, p. 3495 - 3505
1-Cyano-1-cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Cyano-1-cyclopropanecarboxylic acid manufacturers
- Product
- 1-Cyano-1-cyclopropanecarboxylic acid 6914-79-0
- Price
- US $6.86/KG
- Min. Order
- 1KG
- Purity
- 95.0%-99.0%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-03-10