(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol
- Product Name
- (5-Fluoro-2-methoxy-pyridin-3-yl)-methanol
- CAS No.
- 874822-98-7
- Chemical Name
- (5-Fluoro-2-methoxy-pyridin-3-yl)-methanol
- Synonyms
- 5-Fluoro-2-methoxy-3-pyridinemethanol;3-Pyridinemethanol, 5-fluoro-2-methoxy-;(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol
- CBNumber
- CB31554125
- Molecular Formula
- C7H8FNO2
- Formula Weight
- 157.14
- MOL File
- 874822-98-7.mol
(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol Property
- Boiling point:
- 236.2±35.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.80±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F402450
- Product name
- (5-Fluoro-2-methoxypyridin-3-yl)methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC201339
- Product name
- (5-Fluoro-2-methoxypyridin-3-yl)methanol
- Purity
- 98%
- Packaging
- 100mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- PC201339
- Product name
- (5-Fluoro-2-methoxypyridin-3-yl)methanol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- 3863AC
- Product name
- (5-Fluoro-2-methoxypyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- 3863AC
- Product name
- (5-Fluoro-2-methoxypyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $186
- Updated
- 2021/12/16
(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol Chemical Properties,Usage,Production
Synthesis
122433-52-7
874822-98-7
General procedure for the synthesis of 5-fluoro-3-hydroxymethyl-2-methoxypyridine from 5-fluoro-2-methoxynicotinic acid methyl ester: To a 200 mL tetrahydrofuran solution of 5-fluoro-2-methoxynicotinic acid methyl ester (35, 10 g, 54.0 mmol) was added slowly and dropwise to lithium aluminum hydroxide (81 mL, 1 M solution in tetrahydrofuran, 81 mmol) at -78 °C. The reaction temperature was maintained at -78 °C and stirred for several hours. Upon completion of the reaction, 3 mL of water, 3 mL of 15% aqueous sodium hydroxide solution and 10 mL of water were added dropwise to quench the reaction. Subsequently, 200 mL of methyl tert-butyl ether was added for dilution. The solid insoluble material was removed by filtration and the filtrate was concentrated under vacuum to afford the target compound 5-fluoro-3-hydroxymethyl-2-methoxypyridine (36, 8 g, 50.9 mmol, 94% yield) as a white solid.
References
[1] Patent: US9096593, 2015, B2. Location in patent: Page/Page column 98; 99
(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol Preparation Products And Raw materials
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