(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol

(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol Property

Boiling point:

236.2±35.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

12.80±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety

HS Code 

2933399990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

(5-Fluoro-2-methoxy-pyridin-3-yl)-methanol Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 5-fluoro-3-hydroxymethyl-2-methoxypyridine from 5-fluoro-2-methoxynicotinic acid methyl ester: To a 200 mL tetrahydrofuran solution of 5-fluoro-2-methoxynicotinic acid methyl ester (35, 10 g, 54.0 mmol) was added slowly and dropwise to lithium aluminum hydroxide (81 mL, 1 M solution in tetrahydrofuran, 81 mmol) at -78 °C. The reaction temperature was maintained at -78 °C and stirred for several hours. Upon completion of the reaction, 3 mL of water, 3 mL of 15% aqueous sodium hydroxide solution and 10 mL of water were added dropwise to quench the reaction. Subsequently, 200 mL of methyl tert-butyl ether was added for dilution. The solid insoluble material was removed by filtration and the filtrate was concentrated under vacuum to afford the target compound 5-fluoro-3-hydroxymethyl-2-methoxypyridine (36, 8 g, 50.9 mmol, 94% yield) as a white solid.

References

[1] Patent: US9096593, 2015, B2. Location in patent: Page/Page column 98; 99