1-(4-chloropyridin-2-yl)ethanone
- Product Name
- 1-(4-chloropyridin-2-yl)ethanone
- CAS No.
- 60159-37-7
- Chemical Name
- 1-(4-chloropyridin-2-yl)ethanone
- Synonyms
- 2-Acetyl-4-chloropyridine;1-(4-Chloropyridine-2-yl);1-(4-Chloro-2-pyridyl)ethanone;1-(4-chloropyridin-2-yl)ethanone;1-(4-Chloro-2-pyridinyl)-ethanone;1-(4-Chloropyridine-2-yl)ethanone;Ethanone, 1-(4-chloro-2-pyridinyl)-;1-(4-chloropyridin-2-yl)ethan-1-one;1-(4-chloropyridin-2-yl)ethanone ISO 9001：2015 REACH
- CBNumber
- CB31556033
- Molecular Formula
- C7H6ClNO
- Formula Weight
- 155.58
- MOL File
- 60159-37-7.mol
1-(4-chloropyridin-2-yl)ethanone Property
- Melting point:
- 35 - 37°C
- Boiling point:
- 238℃
- Density
- 1.233
- Flash point:
- 98℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- pka
- 1.06±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C384425
- Product name
- 1-(4-Chloropyridin-2-yl)ethanone
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 058905
- Product name
- 1-(4-Chloro-pyridin-2-yl)-ethanone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $270
- Updated
- 2021/12/16
- Product number
- Y15329
- Product name
- 1-(4-Chloropyridin-2-yl)ethanone
- Purity
- 98%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0037389
- Product name
- 1-(4-Chloropyridin-2-yl)ethan-1-one
- Purity
- >97.0%
- Packaging
- 100mg
- Price
- $92
- Updated
- 2021/12/16
- Product number
- CS-0037389
- Product name
- 1-(4-Chloropyridin-2-yl)ethan-1-one
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
1-(4-chloropyridin-2-yl)ethanone Chemical Properties,Usage,Production
Uses
1-(4-Chloropyridin-2-yl)ethanone is a useful reagent for the asymmetric synthesis of pyridylalkylamines.
Synthesis
19235-89-3
917-64-6
60159-37-7
4-Chloro-2-cyanopyridine (60 g, 0.42 mol) was dissolved in THF (1000 ml) in a 2-liter three-necked flask fitted with a stirrer and a thermometer under a protective atmosphere of N2 and cooled to 0°C by an ice bath. Commercially available magnesium methyl iodide (200 ml of a 3M solution of THF, 0.6 mol) was added slowly and dropwise over the course of about 45 min. A clarified dark colored solution was initially formed. The rate of dropwise acceleration of the methylmagnesium iodide was adjusted to maintain the reaction temperature between 0-10°C. After addition, a green suspension was obtained, which was continued to be stirred at 0°C for 2 hours. Subsequently, ice water (1500 mL) was added to the reaction mixture. 2M HCl was slowly added until the pH of the reaction mixture reached 2 and the temperature was about 25°C. The mixture was stirred for another 15 minutes. Multiple extractions (using EtOAc and water) were then performed. The combined organic phases were washed with saturated aqueous sodium chloride solution and dried with Na2SO4. All solvents were removed by distillation under reduced pressure in a rotary evaporator to give 66 g of yellow brown oily crude product. The crude product was purified by column chromatography (800 g silica gel 60, eluent MTBE). The target fractions confirmed by TLC analysis were collected, combined and the solvents removed to afford 1-(4-chloropyridyl)-2-acetophenone (51 g, 0.32 mol, 76% yield) as a clarified, dark-colored oil. lC-MS: tR = 1.829 min (UV = 220 nm), tR = 1.842 min (TIC, [M + H]+ = 156); 1H NMR (300 MHz, CDCl3) δ 8.58 (d, 1H), 8.03 (dd, J = 2.1,0.4,1H), 7.47 (dd, J = 5.2,2.1,1H), 2.71 (d, J = 3.2, 3H).
References
[1] Tetrahedron Asymmetry, 2006, vol. 17, # 6, p. 1007 - 1016
[2] Patent: US2012/220587, 2012, A1. Location in patent: Page/Page column 19
[3] Tetrahedron Asymmetry, 2005, vol. 16, # 20, p. 3427 - 3435
1-(4-chloropyridin-2-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-chloropyridin-2-yl)ethanone manufacturers
- Product
- 1-(4-chloropyridin-2-yl)ethanone 60159-37-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06
- Product
- 1-(4-chloropyridin-2-yl)ethanone 60159-37-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24