ChemicalBook > CAS DataBase List > 1-(4-chloropyridin-2-yl)ethanone

1-(4-chloropyridin-2-yl)ethanone

Product Name: 1-(4-chloropyridin-2-yl)ethanone
CAS No.: 60159-37-7
Chemical Name: 1-(4-chloropyridin-2-yl)ethanone
Synonyms: 2-Acetyl-4-chloropyridine;1-(4-Chloropyridine-2-yl);1-(4-Chloro-2-pyridyl)ethanone;1-(4-chloropyridin-2-yl)ethanone;1-(4-Chloro-2-pyridinyl)-ethanone;1-(4-Chloropyridine-2-yl)ethanone;Ethanone, 1-(4-chloro-2-pyridinyl)-;1-(4-chloropyridin-2-yl)ethan-1-one;1-(4-chloropyridin-2-yl)ethanone ISO 9001：2015 REACH
CBNumber: CB31556033
Molecular Formula: C7H6ClNO
Formula Weight: 155.58
MOL File: 60159-37-7.mol

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1-(4-chloropyridin-2-yl)ethanone Property

Melting point:: 35 - 37°C
Boiling point:: 238℃
Density: 1.233
Flash point:: 98℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 1.06±0.10(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C384425
Product name: 1-(4-Chloropyridin-2-yl)ethanone
Packaging: 50mg
Price: $50
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: Y15329
Product name: 1-(4-Chloropyridin-2-yl)ethanone
Purity: 98%
Packaging: 1g
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0037389
Product name: 1-(4-Chloropyridin-2-yl)ethan-1-one
Purity: >97.0%
Packaging: 100mg
Price: $92
Updated: 2021/12/16

ChemScene

Product number: CS-0037389
Product name: 1-(4-Chloropyridin-2-yl)ethan-1-one
Purity: >97.0%
Packaging: 250mg
Price: $153
Updated: 2021/12/16

Matrix Scientific

Product number: 058905
Product name: 1-(4-Chloro-pyridin-2-yl)-ethanone
Purity: 95+%
Packaging: 1g
Price: $270
Updated: 2021/12/16

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1-(4-chloropyridin-2-yl)ethanone Chemical Properties,Usage,Production

Uses

1-(4-Chloropyridin-2-yl)ethanone is a useful reagent for the asymmetric synthesis of pyridylalkylamines.

Synthesis

19235-89-3

917-64-6

60159-37-7

4-Chloro-2-cyanopyridine (60 g, 0.42 mol) was dissolved in THF (1000 ml) in a 2-liter three-necked flask fitted with a stirrer and a thermometer under a protective atmosphere of N2 and cooled to 0°C by an ice bath. Commercially available magnesium methyl iodide (200 ml of a 3M solution of THF, 0.6 mol) was added slowly and dropwise over the course of about 45 min. A clarified dark colored solution was initially formed. The rate of dropwise acceleration of the methylmagnesium iodide was adjusted to maintain the reaction temperature between 0-10°C. After addition, a green suspension was obtained, which was continued to be stirred at 0°C for 2 hours. Subsequently, ice water (1500 mL) was added to the reaction mixture. 2M HCl was slowly added until the pH of the reaction mixture reached 2 and the temperature was about 25°C. The mixture was stirred for another 15 minutes. Multiple extractions (using EtOAc and water) were then performed. The combined organic phases were washed with saturated aqueous sodium chloride solution and dried with Na2SO4. All solvents were removed by distillation under reduced pressure in a rotary evaporator to give 66 g of yellow brown oily crude product. The crude product was purified by column chromatography (800 g silica gel 60, eluent MTBE). The target fractions confirmed by TLC analysis were collected, combined and the solvents removed to afford 1-(4-chloropyridyl)-2-acetophenone (51 g, 0.32 mol, 76% yield) as a clarified, dark-colored oil. lC-MS: tR = 1.829 min (UV = 220 nm), tR = 1.842 min (TIC, [M + H]+ = 156); 1H NMR (300 MHz, CDCl3) δ 8.58 (d, 1H), 8.03 (dd, J = 2.1,0.4,1H), 7.47 (dd, J = 5.2,2.1,1H), 2.71 (d, J = 3.2, 3H).

References

[1] Tetrahedron Asymmetry, 2006, vol. 17, # 6, p. 1007 - 1016
[2] Patent: US2012/220587, 2012, A1. Location in patent: Page/Page column 19
[3] Tetrahedron Asymmetry, 2005, vol. 16, # 20, p. 3427 - 3435

1-(4-chloropyridin-2-yl)ethanone Preparation Products And Raw materials

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View Lastest Price from 1-(4-chloropyridin-2-yl)ethanone manufacturers

Dideu Industries Group Limited

Product: 1-(4-chloropyridin-2-yl)ethanone 60159-37-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-06

Career Henan Chemical Co

Product: 1-(4-chloropyridin-2-yl)ethanone 60159-37-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

60159-37-7, 1-(4-chloropyridin-2-yl)ethanoneRelated Search:

5-Chloro-2,3-difluoropyridine Pyridinethione ETHANONE,1-(4-CHLORO-3-PYRIDINYL)- 1-(4-CHLORO-BENZENESULFONYL)-PIPERAZINE ETHYL 1-(4-CYANOPHENYL)-4-PIPERIDINECARBOXYLATE 1-(4-Nitrophenyl)-1H-pyrazole 1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDINE-4-CARBOXYLIC ACID 1-(4-TRIFLUOROMETHYLPHENYL)PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER 3,5,6-Trichloropyrid 4-Chloro-2,6-diacetylpyridine 1-(4-chloropyridin-2-yl)ethanone 4,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-β]pyridin-11-one (Loratadine Impurity)

1-(4-chloropyridin-2-yl)ethanone

1-(4-Chloropyridine-2-yl)ethanone

2-Acetyl-4-chloropyridine

1-(4-chloropyridin-2-yl)ethan-1-one

1-(4-Chloro-2-pyridinyl)-ethanone

1-(4-Chloro-2-pyridyl)ethanone

1-(4-Chloropyridine-2-yl)

Ethanone, 1-(4-chloro-2-pyridinyl)-

1-(4-chloropyridin-2-yl)ethanone ISO 9001：2015 REACH

60159-37-7