4-bromo-2,5-difluorobenzaldehyde
- Product Name
- 4-bromo-2,5-difluorobenzaldehyde
- CAS No.
- 357405-75-5
- Chemical Name
- 4-bromo-2,5-difluorobenzaldehyde
- Synonyms
- 104217;CAS:357405-75-5;4-bromo-2,5-difluorobenzaldehyde;Benzaldehyde, 4-bromo-2,5-difluoro-;2-aMino-6-flourobenzoicacid,2-fluoro-6-aminobenzoic acid,6-FLUOROANTHRANILIC ACID,methyl 2-amino-6-fluoro-5-methylbenzoate,2-Amino-6-Fluorobenzoic,RARECHEM AL BO 0279,2-Amino-6-fluorobenzoicacid
- CBNumber
- CB31559382
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- 357405-75-5.mol
4-bromo-2,5-difluorobenzaldehyde Property
- Boiling point:
- 237℃
- Density
- 1.758
- Flash point:
- 97℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline solid
- color
- Off white to faint yellow
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS023621
- Product name
- 4-Bromo-2,5-difluorobenzaldehyde
- Packaging
- 100 mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- B997238
- Product name
- 4-Bromo-2,5-difluorobenzaldehyde
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B997238
- Product name
- 4-Bromo-2,5-difluorobenzaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB105619
- Product name
- 4-bromo-2,5-difluorobenzaldehyde
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- PC210045
- Product name
- 4-Bromo-2,5-difluorobenzaldehyde
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
4-bromo-2,5-difluorobenzaldehyde Chemical Properties,Usage,Production
Synthesis
327-51-5
68-12-2
357405-75-5
Example 31 Preparation of 4-bromo-2,5-difluorobenzaldehyde To a solution of 2,5-dibromo-1,4-difluorobenzene (10.0 g, 36.77 mmol) in ether (150 mL) was added slowly and dropwise to butyllithium (2.5 M hexane solution, 14.86 mL, 37.15 mmol) at -78 °C under nitrogen protection. The reaction mixture was stirred at -78 °C for 30 min. Subsequently, a solution of anhydrous N,N-dimethylformamide (3.13 mL, 40.46 mmol) in ether (10 mL) was added dropwise and the reaction system was slowly warmed to room temperature over a period of 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (25 mL) and extracted with ether. The organic phases were combined, washed with saturated brine solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure (note: the product is highly volatile). The crude product was purified by fast column chromatography (silica gel as stationary phase, eluent 2-20% ethyl acetate in hexane solution) to afford the title compound 4-bromo-2,5-difluorobenzaldehyde as a light yellow solid (7.0 g, 86% yield). 1H NMR (400 MHz, CDCl3): δ 7.50 (dd, J = 5.08,8.92 Hz, 1H), 7.62 (dd, J = 5.80,7.68 Hz, 1H), 10.30 (d, J = 2.76 Hz, 1H).
References
[1] Patent: US2014/274696, 2014, A1. Location in patent: Paragraph 0289; 0290
[2] Patent: US2014/200215, 2014, A1. Location in patent: Paragraph 1205; 1206
[3] Patent: WO2013/74641, 2013, A1. Location in patent: Paragraph 00350
[4] Patent: WO2012/149413, 2012, A1. Location in patent: Page/Page column 63
[5] Patent: US2010/222345, 2010, A1. Location in patent: Page/Page column 97
4-bromo-2,5-difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-bromo-2,5-difluorobenzaldehyde manufacturers
- Product
- 4-bromo-2,5-difluorobenzaldehyde 357405-75-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
- Product
- 4-bromo-2,5-difluorobenzaldehyde 357405-75-5
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.8%
- Supply Ability
- 100tons
- Release date
- 2024-08-22
- Product
- 4-bromo-2,5-difluorobenzaldehyde 357405-75-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12