ChemicalBook > CAS DataBase List > BI 2536

BI 2536

Product Name
BI 2536
CAS No.
755038-02-9
Chemical Name
BI 2536
Synonyms
BI 2536;CS-1984;BI-2536(R-);(R)-BI-2536;BI 2536, >=98%;BI2536/BI-2536;BI 2536 USP/EP/BP;BI 2536;BI-2536; BI2536;Boehringer PLK-1 inhibitor;BI-2536, BoehringerPLK-1 inhibitor
CBNumber
CB31562104
Molecular Formula
C28H39N7O3
Formula Weight
521.65
MOL File
755038-02-9.mol
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BI 2536 Property

Density 
1.28
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form 
Yellow powder.
pka
14.09±0.20(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17385
Product name
BI 2536
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17385
Product name
BI 2536
Purity
≥95%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
17385
Product name
BI 2536
Purity
≥95%
Packaging
10mg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
17385
Product name
BI 2536
Purity
≥95%
Packaging
50mg
Price
$758
Updated
2024/03/01
TRC
Product number
B373470
Product name
BI2536
Packaging
5mg
Price
$105
Updated
2021/12/16
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BI 2536 Chemical Properties,Usage,Production

Description

BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1?and selective2?Polo-like kinase inhibitor?that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1?It was later found to be a potent inhibitor (IC50?= 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3?BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4

Uses

BI 2536 is a PLK1 inhibitor, inducing apoptosis together with micro-tubule-destabilizing drugs in preclinical rhabdomyosarcoma models. Anti-cancer and potent PLK1 inhibitor.

target

Plk1

References

1) Steegmaier?et al.?(2007),?BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo; Curr. Biol.,?17?316 2) Davis?et al.?(2011),?Comprehensive analysis of kinase inhibitor selectivity; Nat. Biotechnol.,?29?1046 3) Ciceri?et al.?(2014),?Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat. Chem. Biol.,?10?305 4) Xiao?et al.?(2016),?Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival; Mol. Cell,?64?493

BI 2536 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 2536 Suppliers

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755038-02-9, BI 2536Related Search:

D-ERYTHRO-SPHINGOSINE Bortezomib Alisertib (MLN8237) PD 0332991 HCl Volasertib (BI 6727) Afatinib Olaparib Selumetinib BML-275 PLX-4720 CX-4945 Fluoxetine hydrochloride Alpelisib (BYL719) Tubastatin A hydrochloride N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride Neratinib Glucagon Receptor Antagonist I BI 2536

  • BI-2536, BoehringerPLK-1 inhibitor
  • 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
  • BI 2536
  • Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-
  • Boehringer PLK-1 inhibitor
  • BI-2536(R-)
  • BI2536/BI-2536
  • (R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
  • 4-(8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylaMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
  • BI 2536 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
  • BI 2536, >=98%
  • 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
  • BI 2536;BI-2536; BI2536
  • (R)-BI-2536
  • CS-1984
  • (R)-4-((8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-
  • BI 2536 USP/EP/BP
  • BI-2536 Plk1 inhibitor potent ATP-competitive
  • 755038-02-9
  • 755038-03-9
  • C28H39N7O3
  • Inhibitors
  • API