2-Chloro-6-aminopyrazine

Product Name: 2-Chloro-6-aminopyrazine
CAS No.: 33332-28-4
Chemical Name: 2-Chloro-6-aminopyrazine
Synonyms: TIMTEC-BB SBB005488;6-chlorpyrazin-2-amin;6-CHLOROPYRAZIN-2-AMINE;6-Chloro-2-pyrazinaMine;6-Chloro-2-aMinopyrazine;6-AMino-2-chloropyrazine;2-chloro-6-aminopyrazine;2-AMINO-6-CHLOROPYRAZINE;6-Chloro-2-pyrazinylaMine;6-CHLOROPYRAZIN-2-YLAMINE
CBNumber: CB3160912
Molecular Formula: C4H4ClN3
Formula Weight: 129.55
MOL File: 33332-28-4.mol

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2-Chloro-6-aminopyrazine Property

Melting point:: 150-152°C
Boiling point:: 282.8±35.0 °C(Predicted)
Density: 1.437±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in dimethyl sulfoxide and methanol.
form: Solid
pka: 0.89±0.10(Predicted)
color: Purple
InChI: InChI=1S/C4H4ClN3/c5-3-1-7-2-4(6)8-3/h1-2H,(H2,6,8)
InChIKey: JTPXVCKCLBROOJ-UHFFFAOYSA-N
SMILES: C1(N)=NC(Cl)=CN=C1
LogP: 0.950
CAS DataBase Reference: 33332-28-4(CAS DataBase Reference)
EPA Substance Registry System: 2-Amino-6-chloropyrazine (33332-28-4)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-22
Safety Statements: 26-36/37/39-60-37
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2145
Product name: 2-Amino-6-chloropyrazine
Purity: >98.0%(GC)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: A2145
Product name: 2-Amino-6-chloropyrazine
Purity: >98.0%(GC)
Packaging: 5g
Price: $111
Updated: 2025/07/31

TRC

Product number: C380350
Product name: 6-Chloro-2-pyrazinamine
Packaging: 50g
Price: $195
Updated: 2021/12/16

TRC

Product number: C380350
Product name: 6-Chloro-2-pyrazinamine
Packaging: 100g
Price: $445
Updated: 2021/12/16

Oakwood

Product number: 002753
Product name: 2-Amino-6-chloropyrazine
Purity: 98%
Packaging: 1g
Price: $9
Updated: 2021/12/16

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2-Chloro-6-aminopyrazine Chemical Properties,Usage,Production

Chemical Properties

2-Chloro-6-aminopyrazine is Purple Solid

Uses

2-Chloro-6-aminopyrazine is a disubstituted pyrazine used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Uses

2-Amino-6-chloropyrazine is used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.

Synthesis

4774-14-5

33332-28-4

General procedure for the synthesis of 2-amino-6-chloropyrazine from 2,6-dichloropyrazine: 2,6-dichloropyrazine (10.0 g, 67.1 mmol) and ammonia (100 mL) were sequentially added to a hydrothermal reactor and reacted at 100 °C for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The filter cake was pulped with hexane (16 mL) to give a final white solid of 8.2 g of 2-amino-6-chloropyrazine in 95.0% yield.

References

[1] Patent: CN107857737, 2018, A. Location in patent: Paragraph 0011-0013; 0021-0023; 0030-0032; 0040-0042; 0049
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8328 - 8342
[3] Patent: WO2013/68755, 2013, A1. Location in patent: Page/Page column 67, 68
[4] Patent: WO2017/5786, 2017, A1. Location in patent: Page/Page column 23; 24
[5] Tetrahedron, 1984, vol. 40, # 24, p. 5081 - 5088

2-Chloro-6-aminopyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-aminopyrazine Suppliers

Americas 1 Canada 2 China 273 Europe 1 Germany 5 India 7 Japan 3 Ukraine 1 United Kingdom 15 United States 41 USA 1 Global 350

Suzhou Xinrui Biotechnology Co., Ltd.

Tel: 13401437572
Email: xinruibiotech01@163.com
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Shanghai ChemIDo Co., Ltd.

Tel: 19301251526
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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Alfa Aesar

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Email: saleschina@alfa-asia.com
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TAIYUAN RHF CO.,LTD.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
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View Lastest Price from 2-Chloro-6-aminopyrazine manufacturers

R&D Scientific Inc.

Product: 2-Amino-6-chloropyrazine 33332-28-4
Price: US $650.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-03-27

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Chloro-6-aminopyrazine Basic information 33332-28-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-13

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-6-aminopyrazine 33332-28-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 800 tons
Release date: 2020-04-28

33332-28-4, 2-Chloro-6-aminopyrazineRelated Search:

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TIMTEC-BB SBB005488

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2-Chloro-6-aminopyrazine ISO 9001：2015 REACH

2-Chloro-6-aminopyrazine Basic information

33332-28-4

amine| alkyl chloride

Pyrazines, Pyrimidines & Pyridazines

Pyrazine

Pyrazines

Nitrogen cyclic compounds

Amines

blocks