ChemicalBook > CAS DataBase List > propargyl bromide

propargyl bromide

Product Name
propargyl bromide
CAS No.
106-96-7
Chemical Name
propargyl bromide
Synonyms
3-Bromoprop-1-yne;PROPARGYL BROMIDE;propargyl;PBR;3-BROMO-1-PROPYNE;G-BROMOALLYLENE;1-Brom-2-propin;3-bromo-1-propyn;propargyl bromide solution;DK460
CBNumber
CB3162370
Molecular Formula
C3H3Br
Formula Weight
118.96
MOL File
106-96-7.mol
More
Less

propargyl bromide Property

Melting point:
-61°C
Boiling point:
97 °C
Density 
1.38 g/mL at 20 °C
refractive index 
n20/D 1.494
Flash point:
65 °F
storage temp. 
2-8°C
solubility 
Chloroform, Methanol (Slightly)
form 
Liquid
color 
Colorless - Yellow
Water Solubility 
Miscible with ethanol, ether, benzene, carbon tetrachloride and chloroform. Immiscible with water.
Sensitive 
Light Sensitive
BRN 
605309
Exposure limits
ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
InChIKey
YORCIIVHUBAYBQ-UHFFFAOYSA-N
CAS DataBase Reference
106-96-7(CAS DataBase Reference)
NIST Chemistry Reference
1-Propyne, 3-bromo-(106-96-7)
EPA Substance Registry System
Propargyl bromide (106-96-7)
More
Less

Safety

Hazard Codes 
F,T,C
Risk Statements 
60-61-20/21-25-63-36/37/38-11-67-65-48/20
Safety Statements 
53-16-36/37/39-45-37/39-28A-26-62-36/37
RIDADR 
UN 2345 3/PG 2
WGK Germany 
3
RTECS 
UK4375000
F 
8
Hazard Note 
Highly Flammable/Toxic/Corrosive
TSCA 
Yes
HazardClass 
3
PackingGroup 
II
HS Code 
29033990
Hazardous Substances Data
106-96-7(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H304May be fatal if swallowed and enters airways

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
530409
Product name
Propargyl bromide solution
Purity
80 wt. % in xylene
Packaging
50g
Price
$101
Updated
2024/03/01
Sigma-Aldrich
Product number
530409
Product name
Propargyl bromide solution
Purity
80 wt. % in xylene
Packaging
125g
Price
$132.6
Updated
2024/03/01
TCI Chemical
Product number
P0484
Product name
Propargyl Bromide (stabilized with MgO)
Purity
>97.0%(GC)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
P0484
Product name
Propargyl Bromide (stabilized with MgO)
Purity
>97.0%(GC)
Packaging
100g
Price
$141
Updated
2024/03/01
Alfa Aesar
Product number
A16580
Product name
Propargyl bromide, 80% in toluene, stab. with MgO
Packaging
50ml
Price
$97
Updated
2024/03/01
More
Less

propargyl bromide Chemical Properties,Usage,Production

Description

Propargyl bromide is a Shock sensitive liquid, lachrymator. Supplied as an 80% solution in toluene stabilized with magnesium oxide. Alternative formulations are currently under development.

Chemical Properties

yellow solution

Uses

Propargyl bromide, 80% in toluene is used to prepare betulonic acid-peptide conjugates with anti-inflammatory activity and propargylic amines employed in enyne metathesis. It finds application in the propargylation of spiro ketones, allylic alcohols and enone complexes. In Barbier-type reaction, it reacts with aldehydes to give alkyne alcohols. It is actively involved in the synthesis of polyethylene glycol (PEG) and peptide-grafted polyesters.

Uses

Propargyl Bromide is used in the synthesis of betulonic acid-peptide conjugates with anti-inflammatory activity. It is also used in the synthesis of PEG and peptide-grafted polyesters and make propargylic amines employed in enyne metathesis. Additionally, It is Employed in the propargylation of spiro ketones, allylic alcohols, and enone complexes.

Preparation

Add hydrogen bromide and solvent into the reaction flask, in the presence of CuBr and Cu catalyst, add propargyl alcohol dropwise with stirring, after the drop is completed, the temperature is slightly raised to react, and then post-processing, rectification to obtain bromopropane. alkyne. Reaction equation: CH≡C-CH2OH+HBr→CH≡C-CH2Br+H2O or the product can also be obtained by reacting propargyl alcohol with (PhO)3PBr2 in the presence of pyridine.
It is derived from the reaction of propargyl alcohol with phosphorus bromide. The propargyl alcohol was added to pyridine under cooling, and phosphorus tribromide was slowly added dropwise with stirring at -5°C, and the reaction temperature was maintained below 0°C. After the addition was completed, stirring was continued for 15 min. Then, vacuum distillation is performed to collect all the distillate, and fractional distillation is carried out again under normal pressure to obtain the finished product. Or add a small amount of pyridine to dry propargyl alcohol, add phosphorus tribromide and a small amount of pyridine solution dropwise at 0 °C under stirring, stir for 20 min after dropping, and distill under reduced pressure to obtain the product. Reaction equation: CH≡C-CH2OH+PBr3→CH≡C-CH2Br

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 483, 1963 DOI: 10.1039/jr9630005127

General Description

A colorless to light yellow liquid substance with a sharp odor. Flash point 65°F. Denser than water and insoluble in water. Vapors are heavier than air. May be irritating to skin and eyes. Used to make other chemicals. 3-Bromopropyne may decompose explosively with mild shock.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

3-Bromopropyne is soluble in alcohol, ether, chloroform, carbon tetrachloride and carbon disulfide. 3-Bromopropyne is highly flammable and a dangerous fire risk, sensitive to shock. 3-Bromopropyne is used in organic syntheses, preparation of resins and perfume intermediates [Hawley]. There is a high danger of formation of explosive metal acetylides, when 3-Bromopropyne comes in contact with copper, high-copper alloys, mercury, or silver.

Hazard

Flammable, dangerous fire and explosion risk. Irritant.

Health Hazard

3-Bromopropyne is very toxic via the oral route. If inhaled, may be harmful; contact may cause burns to skin and eyes.

Fire Hazard

3-Bromopropyne detonates at 428F or more; ignites by impact. Emits highly toxic fumes of bromides when heated to decomposition. Reacts vigorously with oxidizing materials. Becomes shock-sensitive when mixed with chloropicrin. Unstable, avoid heat, flame, shock, and other chemicals

Pharmacology

Mode of action is considered to be reaction with nucleophiles in living organisms.

Safety Profile

A poison by ingestion. A dangerous fire hazard when exposed to heat or flame. The aerated liquid may be ignited by pressure. A dangerous, extremely shock-sensitive explosive. It can detonate when heated to 22O°C, by impact (especially when mixed with chloropicrin), or when heated whde confined. May explode on contact with copper, high copper alloys, mercury, or silver. Mixtures with trichloronitromethane are shockand heat- sensitive explosives. Can react vigorously with oxidizing materials. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of Br-. See also ACETYLENE COMPOUNDS and BROMIDES.

Metabolism

Reacts slowly with water to yield propargyl alcohol and bromide ion. It is expected to move as a typical fumigant through the soil. Probably not an ozone-depleting substance due to decomposition on absorption of ultraviolet light.

propargyl bromide Preparation Products And Raw materials

Raw materials

Propargyl alcohol

Preparation Products

2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one HALOPROGIN 2,4,5-Trichlorophenyl-propynyl ether Terbinafine 2-AMINOPENT-4-YNENITRILE
More
Less

propargyl bromide Suppliers

Americas 1 Belgium 3 Canada 2 China 263 Cyprus 1 Europe 3 France 2 Germany 4 India 37 Japan 8 Slovakia 1 South Korea 2 Switzerland 4 The Netherlands 1 Ukraine 2 United Kingdom 16 United States 52 Global 402
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
BromOrganics Corporation
Tel
--
Fax
--
Email
sales@bromorganics.com
Country
United States
ProdList
1065
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
SynQuest Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2301
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Exim-Indis, Inc. (part of Exim Corporation and Indis N.V.)
Tel
--
Fax
--
Email
info@exim-indis.com
Country
United States
ProdList
440
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
SLN Pharmachem
Tel
--
Fax
--
Email
slnpharmachem@vsnl.net
Country
United States
ProdList
188
Advantage
43
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Global ChemSources, Inc.
Tel
--
Fax
--
Email
sales@globalchemsources.com
Country
United States
ProdList
132
Advantage
30
Parish Chemical Company
Tel
--
Fax
--
Country
United States
ProdList
1248
Advantage
47
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
ChemSampCo, Inc.
Tel
--
Fax
--
Email
sales@chemsampco.com
Country
United States
ProdList
3585
Advantage
60
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Narchem Corporation
Tel
--
Fax
--
Email
sales@narchem.com
Country
United States
ProdList
2813
Advantage
60
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Chemiplus Corporation
Tel
--
Fax
--
Email
okazaki@chemiplus.com
Country
United States
ProdList
3198
Advantage
38
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
ESPI Corp Inc.
Tel
--
Fax
--
Email
sales@espimetals.com
Country
United States
ProdList
507
Advantage
76
Neogen Chemicals Limited
Tel
--
Fax
--
Email
info@neogenchem.com
Country
United States
ProdList
286
Advantage
51
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
GFS Chemicals
Tel
--
Fax
--
Email
gfschem@gfschemicals.com
Country
United States
ProdList
3403
Advantage
75
Fisher Scientific
Tel
--
Fax
--
Email
sales@fishersci.com
Country
United States
ProdList
2337
Advantage
86
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from propargyl bromide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
3-Bromopropyne 106-96-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-19
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Bromopropyne 106-96-7
Price
US $9.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-14
Hong Kong Excellence Biotechnology Co., Ltd.
Product
3-Bromopropyne 106-96-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12

106-96-7, propargyl bromideRelated Search:

3-Bromo-1-propanol Profenofos Sodium bromate Rocuronium bromide Propiolic Acid :(S)-2-Methyl-3-(2-propynyl)-4-oxocyclopent-2-enyl-(lR)-cis,trans-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate Propyne PROPARGYLAMINE Propionyl bromide 3-Bromopropionic acid Ethidium bromide 3-BROMOPROPIONITRILE Dimidium bromide Allyl bromide Vecuronium bromide Propargyl alcohol Methyl bromide 1-BROMO-2-BUTYNE

  • G-BROMOALLYLENE
  • 3-BROMO-1-PROPYNE
  • 3-BROMOPROPYNE
  • 1-Brom-2-propin
  • 1-Bromo-2-propyne
  • 2-Propynyl bromide
  • 3-bromo-1-propyn
  • 3-bromo-propyn
  • -Bromo-propyne
  • gamma-Bromoallylene
  • Propargyl bromide, 80% in toluene, stab. with MgO
  • Propargyl bromide, 97%, 80% w/w in toluene
  • Propargyl Bromide (stabilized with MgO)
  • Propargyl Bromide (80% in Toluene, ca. 9.2mol/L)
  • PROPARGYL BROMIDE
  • propargyl bromide，3-bromo-1-propyne
  • 1-Bromopropan-2-yne
  • Dow S-1925
  • PBR
  • 3-Bromo-1-propune
  • propagyl bromide
  • Propargyl Bromide, 80% in toluene/Pure
  • Propargyl BroMide, Pure
  • Propargyl broMide ,80% [80 wt% solution in toluene, stabilized]
  • Propargyl bromide [80 wt% solution in toluene, 0.3% magnesium oxide as stabilizer]
  • Propargyl bromide solution,3-Bromo-1-propyne
  • Propargyl bromide (20% wt.in toluene)
  • Propargyl bromide, 80% solution in toluene
  • Propargyl bromide, 80wt.% solution in toluene, stabilized, AcroSeal
  • Progargyl bromide
  • propargyl
  • propargylbromide101
  • Propyne, 3-bromo-
  • ProPargyl Bromide 97% min or 80% in Toluene
  • PROPARGYL BROMIDE, 80 WT. % SOLUTION IN TOLUENE
  • PROPARGYL BROMIDE SOLUTION, ~80% IN TOLU ENE, STAB.
  • PROPARGYL BROMIDE, 80 WT. % SOLUTION IN
  • Propargyl bromide, 80 wt% solution in toluene, stabilized
  • PROPARGYL BROMIDE, 80% W/W SOLUTION IN TOLUENE
  • 3-Bromopropine
  • 1-Propyne, 3-bromo-
  • propargyl bromide solution
  • 3-Bromoprop-1-yne
  • 3-bromoallylene
  • Propargylbromid
  • 1-brom-2-propine
  • PROPARGYL BROMIDE: 80% IN TOLUENE, STABILIZED WITH MGO
  • Propargyl broMide soluti
  • Propargyl broMide, 80 wt.% solution in toluene, stabilized with 0.3% MagnesiuM oxide
  • Propargyl BroMide, 80 Percent (w/w) Solution in Toluene, Stabilized with MagnesiuM Oxide
  • Propargyl broMide solution 80 wt. % in toluene
  • Propargyl Bromide (80% in Toluene, ca. 9.2mol/L) (stabilized with MgO)
  • Propargyl bromide solution 80 wt. % in toluene, contains 0.3% magnesium oxide as stabilizer
  • Propargyl bromide solution 80 wt. % in xylene
  • PROPARGYL BROMIDE (~80% IN TOLUENE, STABLIZED WITH 0.3% MAGNESIUM OXIDE)
  • Propargyl broMide solution puruM, ~80% in toluene
  • Propargyl broMide, 80 wt.% solution in toluene, stabilized with 0.3% MagnesiuM oxide, SpcSeal
  • Propargyl bromide solution, 80 wt. % in toluene, stabilized