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Profenofos

Product Name
Profenofos
CAS No.
41198-08-7
Chemical Name
Profenofos
Synonyms
PROFENOPHOS;CURACRON;PROFENFOS;PROFENPHOS;O-(4-BROMO-2-CHLOROPHENYL)-O-ETHYL-S-PROPYL PHOSPHOROTHIOATE;TaMbo;PRAHAR;Calofos;Prowess;SANOFOS
CBNumber
CB9184781
Molecular Formula
C11H15BrClO3PS
Formula Weight
373.63
MOL File
41198-08-7.mol
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Profenofos Property

Melting point:
<25 °C
Boiling point:
110°C (0.001 torr)
Density 
d20 1.455
vapor pressure 
1.24×10-4 Pa (25 °C)
refractive index 
n20D 1.5466
Flash point:
124℃
storage temp. 
APPROX 4°C
solubility 
DMSO: 50 mg/mL (133.82 mM)
Water Solubility 
28 mg l-1 (25 °C)
form 
Oily Liquid
color 
Colorless to light yellow
Specific Gravity
1.455 (20℃)
Merck 
13,7860
BRN 
2150258
LogP
4.2 at 25℃
CAS DataBase Reference
41198-08-7(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorothioic acid, o-(4-bromo-2-chlorophenyl) o-ethyl s-propyl ester(41198-08-7)
EPA Substance Registry System
Profenofos (41198-08-7)
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Safety

Hazard Codes 
Xn,N,T
Risk Statements 
20/21/22-50/53-24-20/22-43
Safety Statements 
36/37-60-61-45-9-7
RIDADR 
3018
WGK Germany 
3
RTECS 
TE6975000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29309090
Hazardous Substances Data
41198-08-7(Hazardous Substances Data)
Toxicity
LD50 in rat (mg/kg): 358-400 orally; ~3300 dermally; LC50 (4 hr) in rat (mg/m3): ~3000 by inhalation (Buholzer); LC50 (96 hr) in rainbow fish: 0.91 mg/l (Kumar, Chapman).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45632
Product name
Profenofos
Purity
PESTANAL
Packaging
250mg
Price
$132
Updated
2024/03/01
TRC
Product number
P755880
Product name
Profenofos
Packaging
1g
Price
$135
Updated
2021/12/16
Usbiological
Product number
287044
Product name
Profenofos
Packaging
500mg
Price
$410
Updated
2021/12/16
ChemScene
Product number
CS-0012846
Product name
Profenofos
Purity
95.92%
Packaging
250mg
Price
$50
Updated
2021/12/16
AK Scientific
Product number
I562
Product name
Profenofos
Packaging
250mg
Price
$81
Updated
2021/12/16
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Profenofos Chemical Properties,Usage,Production

Description

Profenofos is a pale yellow liquid, bp 100 ?C/1.80 Pa, vp 0.124 mPa (25 ?C). Solubility in water is 28 mg/L (25 ?C). It is miscible with most organic solvents. Log Kow = 4.44. It is relatively stable in neutral and mild acid media but hydrolyzed in alkaline media; DT50 values (20 ?C) at pH 5, 7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.

Chemical Properties

Profenofos is a pale yellow liquid. Profenofos is relatively stable under neutral and slightly acidic conditions and unstable under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water (28 mg/L at 25°C) but is completely soluble in organic solvents (ethanol, acetone, toluene, n-octanol and n-hexane) at 25°C.

Uses

Insecticide; acaricide.

Uses

A broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control.

Uses

Profenofos is used to control insects (particularly caterpillars and Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean, potatoes, vegetables, tobacco and a number of other crops

Definition

ChEBI: Profenofos is an organic thiophosphate, an organophosphate insecticide, an organochlorine insecticide and a member of monochlorobenzenes. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a 4-bromo-2-chlorophenol.

General Description

Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.

Air & Water Reactions

Hydrolyzed under alkaline conditions.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Agricultural Uses

Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.

Trade name

CGA-15324®; CURACRON®; POLYCRON®; SELECRON®

Carcinogenicity

In a 2 year carcinogenicity study mice were given diets containing 0, 1, 30, or 100 ppm profenofos (equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85 weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related gross or microscopic lesions, tumors, or biologically significant differences in body weight or food consumption were observed between controls and profenofos-treated animals. Plasma and erythrocyte cholinesterase inhibition occurred at dose levels of 4.5 and 15 mg/kg/day. In another carcinogenicity study, rats were fed diets containing 0, 0.3, 10, or 100 ppm profenofos (equivalent to 0, 0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no increase in tumor incidence in any treated group compared to the control group .

Environmental Fate

Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck et al., 1980)
Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen ph
Chemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

The metabolic transformations of profenofos in plants and animals are similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then conjugated.

Metabolism

Profenofos orally administered to rats is rapidly excreted, mainly in the urine. The principal degradation route is hydrolysis to 4-bromo-2-chlorophenol followed by conjugation. DT50 in soil is about 1 week.

Toxicity evaluation

The acute oral LD50 for rats is 358 mg/kg. Inhalation LC50 (4 h) for rats is about 3 mg/L air. NOEL (2 yr) for rats is 0.3 mg/kg diet (0.015 mg/kg/d). ADI is 0.01 mg/kg b.w.

Degradation

Profenofos is stable under neutral and slightly acid conditions but it is hydrolysed in alkaline solution. The DT50 values at pH 5, 7 and 9 (20°C) were 93 days, 14.6 days and 5.7 hours, respectively (PM).

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Profenofos Suppliers

Jiangsu Baoling Chemical Co., Ltd.
Tel
0513-85056018 13328062001
Fax
+86-513-83518952
Email
baolingchem@163.com
Country
China
ProdList
29
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
SALES@UHNSHANGHAI.COM
Country
China
ProdList
977
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
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View Lastest Price from Profenofos manufacturers

airuikechemical co., ltd.
Product
Profenofos 41198-08-7
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-01
qingdao trust agri chemical co.,ltd
Product
Profenofos 41198-08-7
Price
US $0.00/KG
Min. Order
100KG
Purity
98
Supply Ability
200TONS
Release date
2024-07-17
Longyan Tianhua Biological Technology Co., Ltd
Product
Profenofos 41198-08-7
Price
US $8.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-10-28

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