ChemicalBook > CAS DataBase List > Prothiofos

Prothiofos

Product Name
Prothiofos
CAS No.
34643-46-4
Chemical Name
Prothiofos
Synonyms
Bideron;toyodan;Tokution;ntn-8629;toyothion;TOKUTHION;bayntn8629;PROTHIOFOS;Tokuthhion;PROTHIOPHOS
CBNumber
CB9385630
Molecular Formula
C11H15Cl2O2PS2
Formula Weight
345.25
MOL File
34643-46-4.mol
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Prothiofos Property

Melting point:
25°C
Boiling point:
126.5 °C
Density 
1.3000
vapor pressure 
3.0×10-4 Pa (20 °C)
storage temp. 
APPROX 4°C
form 
liquid
Water Solubility 
0.07 mg l-1(20 °C)
BRN 
1998314
CAS DataBase Reference
34643-46-4(CAS DataBase Reference)
NIST Chemistry Reference
Phosphorodithioic acid, o-(2,4-dichlorophenyl) o-ethyl s-propyl ester(34643-46-4)
EPA Substance Registry System
Prothiofos (34643-46-4)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3082
WGK Germany 
3
RTECS 
TD5680000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H330Fatal if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P284Wear respiratory protection.

P310Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45311
Product name
Prothiofos
Purity
PESTANAL
Packaging
50mg
Price
$32.2
Updated
2021/12/16
TRC
Product number
P838840
Product name
Prothiofos
Packaging
500mg
Price
$160
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
61420
Product name
Prothiofos
Packaging
500 mg
Price
$650
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PST0000040
Product name
PROHIFOS
Purity
95.00%
Packaging
10MG
Price
$885.31
Updated
2021/12/16
AK Scientific
Product number
S528
Product name
Prothiofos
Packaging
50mg
Price
$92
Updated
2021/12/16
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Prothiofos Chemical Properties,Usage,Production

Description

Prothiofos is a colorless liquid. It is nearly insoluble in water (1.7 mg/L at 20 ?C) but readily soluble in most organic solvents. Log Kow = 5.67. It is relatively stable in aqueous media; DT50 values (22 ?C) at pH 4, 7, and 9 are 120, 280, and 12 d, respectively.

Uses

Prothiofos is used to control chewing insects in a range of crops including vegetables, fruit, maize, sugar cane and ornamentals.

Definition

ChEBI: An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.

Metabolic pathway

A report by Nihon Tokushu Noyaku Seizo K.K. (1979) (now Nhon Bayer Agrochem K.K.) has summarised the nature of the photolysis products and metabolites formed by prothiofos in plants, insects, chicken, mice, rats, guinea-pigs and rabbits. Major routes for the metabolism of prothiofos include activation via oxidative desulfuration to the oxon and detoxification by dearylation to give 2,4-dichlorophenol which occur in all media. In addition, cleavage of the P-S bond and loss of the propanethiol moiety is an important detoxification mechanism in mammals but not insects and dechlorination by reductive loss of the 2-chlorine substituent in the phenyl ring occurs in soil, plants and photochemically. Stage II metabolism results in the formation of the glucoside of 2,4-dichlorophenol in plants and insects and the glucuronide and sulfate ester in mammals.

Metabolism

The principal metabolic routes are activation by oxidative desulfuraton and detoxification by dearylation and cleavage of the P?S bond in both animals and plants. Prothiofos is strongly adsorbed in soil; the half-life under field conditions is 1–2 months.

Toxicity evaluation

The acute oral LD50 for rats is 1390–1569 mg/kg. Inhalation LC50 (4 h) for rats is >2.7mg/L air. NOEL (2 yr) for rats is 5mg/kg diet (0.25 mg/kg/d). ADI is 0.1 μg/kg b.w. Prothiofos administered to rats is rapidlymetabolized, and 98% of the dose is excreted in 72 h.

Degradation

Prothiofos is hydrolysed at pH 4,7 and 9 with DT50 values of 120,280 and 12 days, respectively (PM). Takase et al. (1982) examined the photolysis of hexane, methanol, aqueous methanol solutions and thin films of [2H-ethyl] prothiofos and unlabelled prothiofos. The compound was irradiated by UV light from a high pressure mercury vapour lamp (λmax 360 nm) for up to 4 hours or by sunlight for 15 days. Photolysis products were purified by TLC and identified by GC-MS. Under UV irradiation, prothiofos was degraded with a half-life of from 60 minutes (hexane solution) to 420 minutes (thin film). Prothiofos was photolysed under UV light by five main mechanisms: (a) reductive dechlorination at the 2-position of the phenyl ring, (b) desulfuration to the oxon ( P=O ) products, (c) cleavage of the P-S bond and loss of propanethiol, (d) cleavage of the P-O-aryl linkage resulting in the production of phenols and (e) dechlorination at the 4-position of the phenyl ring. The main photochemical reaction product was formed by reductive dechlorination of the 2-position of the phenyl ring to give 4-chloroprothiofos (2). The next most important mechanism was photooxidation of the P=S moiety (a common reaction of phosphorothioates and also noted with parathion, fenitrothion, disulfoton and fenthoate) to give prothiofos oxon (3), which was subsequently 2- dechlorinated to give 4. Loss of propanethiol via cleavage of the P-S bond of prothiofos oxon (3) and the 2-dechlorinated oxon (4) afforded 5 and 6, respectively, in aqueous solution. In hexane solution photoproducts 7 and 8 were formed by the substitution of the Pr-S group by a chlorine atom from the ring.
Dearylation by cleavage of the P-O-aryl linkage gave rise to 2,4- dichlorophenol(9) and 4-chlorophenol(10) which were formed in greater yields in the aqueous media.4-Dechlorination was a minor route, with only a trace of the di-dechloroprothiofos photoproduct (11) being detected. In hexane solution only, a number of other photoproducts were formed of which the most interesting (12) was formed via the displacement of the 2-chlorine atom by the P-S sulfur (Scheme 1).
Under natural sunlight conditions in hexane the level of photodegradation was considerably less. The major photoproducts were prothiofos oxon (3), 4-chloroprothiofos (2) and its oxon (4) and the cyclic phosphorodithioate (12).

Prothiofos Preparation Products And Raw materials

Raw materials

Preparation Products

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Prothiofos Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810- ;025-57798810-
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3756
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
+86-022-6537-8550
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2775
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-65378550- ;022-65378550-
Fax
022-2532-9655
Email
sales@altascientific.com;marketing@altascientific.com
Country
China
ProdList
4515
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4542
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799(To 20)
Fax
0539-6362799(To 20)
Email
775388075@qq.com
Country
China
ProdList
10016
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366-
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9504
Advantage
58
Beijing altar ink quality inspection technology co., LTD
Tel
010-52889049
Email
2250970673@qq.com
Country
CHINA
ProdList
1141
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
400-002-6226
Email
sales@biochemall.cn
Country
China
ProdList
54467
Advantage
58
ShenZhen Ipure Biology import and export company co.,ltd
Tel
18071025641
Email
eric@ipurechemical.com
Country
CHINA
ProdList
11336
Advantage
58
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View Lastest Price from Prothiofos manufacturers

Career Henan Chemical Co
Product
Prothiofos 34643-46-4
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98%HPLC
Supply Ability
g/kg/ton
Release date
2020-02-01

34643-46-4, ProthiofosRelated Search:


  • Bay NTN 8629
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  • dichlorpropaphos
  • ntn-8629
  • ntn8629,4541
  • o-(2,4-Dichlorophenyl) o-ethyl S-propyl dithiophosphate
  • o-ethyl-o-(2,4-dichlorophenyl)-s-n-propyl-dithiophosphate
  • phosphorodithioicacid,o-(2,4-dichlorophenyl)o-ethyls-propylester
  • Phosphorodithioicacid,O-(2,4-dichlorophenyl)O-ethylS-propylester(9CI)
  • Tokution
  • Dithiophosphoric acid O-(2,4-dichlorophenyl)O-ethyl S-propyl ester
  • Phosphorodithioic acid O-(2,4-dichlorophenyl) O-ethyl S-propyl
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  • Tokuthion (TM) 100mg [34643-46-4]
  • Prothiophos 100mg [34643-46-4]
  • toyodan
  • toyothion
  • PROTHIOPHOS
  • PROTHIOFOS
  • O-(2,4-DICHLOROPHENYL)-O-ETHYL-S-PROPYL-PHOSPHORODITHIOATE
  • TOKUTHION
  • TOKUTHION (TM)
  • Prothhiophos
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  • PROTHIOFOS PESTANAL, 250 MG
  • TOKUTHION, 100MG, NEAT
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  • PROTHIOFOS STANDARD
  • O-(2,4-dichlorophenyl)-S-propyl-O-ethylthiophosphate
  • Bayer 123231
  • O-ethyl-O-(2,4-dichlorophenyl)-S-propyl phosphorodithioate
  • Tokuthion @100 μg/mL in MeOH
  • Tokuthion @1000 μg/mL in Hexane
  • Prothiofos@1000 μg/mL in Acetone
  • Prothiophos Solution
  • TokuthionSolution,100mg/l,1ml
  • 34643-46-4
  • C11H15Cl2O2PS2
  • INSECTICIDE
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