ChemicalBook > CAS DataBase List > 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE

2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE

Product Name
2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE
CAS No.
78667-04-6
Chemical Name
2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE
Synonyms
2-Chloromethyl-1-methyl-1H-imida;2-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL;2-(Chloromethyl)-1-methylimidazole hydrochloride;1-Methyl-2-(chloromethyl)imidazole hydrochloride;2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE;2-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride 95%;1H-IMidazole,2-(chloroMethyl)-1-Methyl-, hydrochloride (1:1)
CBNumber
CB3168271
Molecular Formula
C5H8Cl2N2
Formula Weight
167.04
MOL File
78667-04-6.mol
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2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE Property

Melting point:
175 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder
color 
Beige
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Safety

HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C587955
Product name
2-(Chloromethyl)-1-Methyl-1H-ImidazoleHydrochloride
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-N7
Product name
2-(Chloromethyl)-1-methyl-1H-imidazolehydrochloride
Packaging
250mg
Price
$48
Updated
2021/12/16
Matrix Scientific
Product number
133696
Product name
2-(Chloromethyl)-1-methyl-1H-imidazolehydrochloride
Purity
95%+
Packaging
100mg
Price
$64
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC124223
Product name
2-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride
Packaging
250mg
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
133696
Product name
2-(Chloromethyl)-1-methyl-1H-imidazolehydrochloride
Purity
95%+
Packaging
500mg
Price
$136
Updated
2021/12/16
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2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

17334-08-6

78667-04-6

General procedure for the synthesis of 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (BB7) from 1-methyl-2-hydroxymethyl-1H-imidazole (BB6): to a solution of BB6 (35.5 g, 316.96 mmol) in dichloromethane (DCM, 1500 mL) was slowly added thionyl chloride (SOCl2, 330 mL, 4436 mmol ). The reaction mixture was gradually warmed to room temperature and stirred continuously for 5 hours. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The residue was washed sequentially with dichloromethane (DCM, 2 × 500 mL) and ether (Et2O, 2 × 200 mL) to give the final target product BB7 (50 g, 95% yield) as an off-white solid. Thin-layer chromatography (TLC) showed an Rf value of 0.4 (unfolding agent: ethyl acetate).1H NMR (400 MHz, DMSO-d6) data were as follows: δ 7.76 (1H, apparent double peaks), 7.70 (1H, apparent double peaks), 5.17 (2H, single peak), 3.87 (3H, single peak); mass spectrometry (MS) showed an m/z of 131 ([M+H]+ ).

References

[1] Patent: US2012/322722, 2012, A1
[2] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5308 - 5310
[3] Tetrahedron, 1996, vol. 52, # 48, p. 15171 - 15188
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 19, p. 2291 - 2302
[5] Tetrahedron Letters, 2013, vol. 54, # 45, p. 6087 - 6089

2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE Suppliers

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View Lastest Price from 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE 78667-04-6
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

78667-04-6, 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDERelated Search:

2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE 1-BENZYL-2-(CHLOROMETHYL)-1H-IMIDAZOLE HCL 3-METHYLUNDECANE 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE IMIDAZOLE HYDROCHLORIDE 8-CHLORO-2-CHLOROMETHYL-6-TRIFLUOROMETHYL-IMIDAZO[1,2-A]PYRIDINE 1-BENZYL-2-CHLOROMETHYL-1H-BENZOIMIDAZOLE HYDROCHLORIDE 8-CHLORO-2-(CHLOROMETHYL)IMIDAZO[1,2-A]PYRIDINE 6,8-DICHLORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBALDEHYDE ethyl 6,8-dichloroimidazo[1,2-a]pyridine-2-carboxylate 5-CHLORO-2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE 5-(Chloromethyl)-4-methyl-1H-imidazole hydrochloride 2-[6-CHLORO-2-(CHLOROMETHYL)-1H-BENZIMIDAZOL-1-YL]ETHANOL [4-(6,8-DICHLORO-2-METHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YL]-HYDRAZINE 1-(4-CHLOROBENZYL)-2-(CHLOROMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE 2-(1,3-BENZODIOXOL-5-YL)-3,8-DICHLORO-6-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIDINE 8-CHLORO-2-(3,4-DICHLOROPHENYL)-6-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIDINE 6,8-dichloro-2-(chloromethyl)imidazo[1,2-a]pyridine

  • 2-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride 95%
  • 2-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL
  • 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE
  • 1-Methyl-2-(chloromethyl)imidazole hydrochloride
  • 2-(Chloromethyl)-1-methylimidazole hydrochloride
  • 1H-IMidazole,2-(chloroMethyl)-1-Methyl-, hydrochloride (1:1)
  • 2-Chloromethyl-1-methyl-1H-imida
  • 78667-04-6