5-BROMO-2-METHOXYPHENYLACETONITRILE
- Product Name
- 5-BROMO-2-METHOXYPHENYLACETONITRILE
- CAS No.
- 7062-40-0
- Chemical Name
- 5-BROMO-2-METHOXYPHENYLACETONITRILE
- Synonyms
- 2-(5-broMo-2-Methoxyphenyl)acetonitrile;5-BroMo-2-Methoxybenzyl cyanide;5-BROMO-2-METHOXYPHENYLACETONITRILE;5-Bromo-2-methoxybenzeneacetonitrile;Benzeneacetonitrile, 5-broMo-2-Methoxy-;5-Bromo-2-methoxybenzyl cyanide, 4-Bromo-2-(cyanomethyl)anisole
- CBNumber
- CB3172737
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 7062-40-0.mol
5-BROMO-2-METHOXYPHENYLACETONITRILE Property
- Melting point:
- 61-63°C
- Boiling point:
- 182.5-183 °C
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 3439
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B699580
- Product name
- 2-(5-Bromo-2-methoxyphenyl)acetonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B699580
- Product name
- 2-(5-Bromo-2-methoxyphenyl)acetonitrile
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 001799
- Product name
- 5-Bromo-2-methoxyphenylacetonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- FB66255
- Product name
- (5-Bromo-2-methoxyphenyl)acetonitrile
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 8479AE
- Product name
- 5-Bromo-2-methoxyphenylacetonitrile
- Packaging
- 250mg
- Price
- $73
- Updated
- 2021/12/16
5-BROMO-2-METHOXYPHENYLACETONITRILE Chemical Properties,Usage,Production
Uses
2-(5-Bromo-2-methoxyphenyl)acetonitrile is a useful intermediate used in the synthesis of 5-bromo-2-methoxyphenylacetonitrile and some of its derivatives.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 38, p. 2050, 1995 DOI: 10.1021/jm00012a004
Synthesis
7035-03-2
7062-40-0
GENERAL METHODS: N-bromosuccinimide (NBS, 1.5 eq., 0.3 mmol), catalyst (10 mol%, 0.02 mmol) and acetonitrile (CH3CN, 1.0 mL) were sequentially added to the reaction tube, followed by o-methoxybenzeneacetonitrile (0.2 mmol). The reaction mixture was stirred at room temperature in a dark environment for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium thiosulfate (Na2S2O3) aqueous solution (2 mL). The reaction mixture was extracted with ethyl acetate (3.5 mL), and the combined organic phases were washed with saturated brine (10 mL), dried over anhydrous sodium sulfate (Na2SO4), and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was purified by fast chromatography on silica gel column with the eluent of petroleum ether/dichloromethane (5:1, v/v) to afford the target product 5-bromo-2-methoxyphenylacetonitrile.
References
[1] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114
5-BROMO-2-METHOXYPHENYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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