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17ALPHA-HYDROXYPREGNENOLONE

Product Name
17ALPHA-HYDROXYPREGNENOLONE
CAS No.
387-79-1
Chemical Name
17ALPHA-HYDROXYPREGNENOLONE
Synonyms
NSC 63853;17-OH PREG;17alpha-Hydroxy;17-OH Pregnenolone;Dronedarone HCl-d6;Hydroxypregnenolone;17a-Hydroxypregnolone;17A-HYDROXYPREGENOLONE;17-HYDROXYPREGNENOLONE;17α-Hydroxypregnenolone
CBNumber
CB3175435
Molecular Formula
C21H32O3
Formula Weight
332.48
MOL File
387-79-1.mol
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17ALPHA-HYDROXYPREGNENOLONE Property

Melting point:
273℃
Flash point:
9℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form 
Solid
Boiling point:
478.4±45.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
pka
13.02±0.70(Predicted)
color 
White to Off-White
CAS DataBase Reference
387-79-1(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
3
RTECS 
TU5548000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5002
Product name
17α-Hydroxypregnenolone
Packaging
5g
Price
$562
Updated
2024/03/01
Sigma-Aldrich
Product number
H-105
Product name
17α-Hydroxypregnenolone solution
Purity
100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$128
Updated
2024/03/01
Sigma-Aldrich
Product number
S518034
Product name
3BETA,17ALPHA-DIHYDROXYPREGN-5-EN-20-ONE
Purity
AldrichCPR
Packaging
250MG
Price
$28.6
Updated
2022/05/15
Sigma-Aldrich
Product number
R199400
Product name
3-BETA,17-ALPHA-DIHYDROXYPREGN-5-EN-20-ONE
Purity
AldrichCPR
Packaging
1MG
Price
$28.6
Updated
2022/05/15
Cayman Chemical
Product number
29181
Product name
17α-hydroxy Pregnenolone
Packaging
100mg
Price
$44
Updated
2024/03/01
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17ALPHA-HYDROXYPREGNENOLONE Chemical Properties,Usage,Production

Description

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

Uses

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

General Description

17α-hydroxypregnenolone is a derived from pregnenolone.

Biochem/physiol Actions

17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.

17ALPHA-HYDROXYPREGNENOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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17ALPHA-HYDROXYPREGNENOLONE Suppliers

China 52 Europe 2 Germany 3 India 1 Poland 1 Switzerland 1 United Kingdom 7 United States 24 Global 91
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387-79-1, 17ALPHA-HYDROXYPREGNENOLONERelated Search:

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  • 17alpha-Hydroxy
  • (3b)-3,17-dihydroxy-Pregn-5-en-20-one
  • 17a-Hydroxypregnolone
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE
  • 5-Pregnen-3b,17-dihydroxy-3-one
  • 3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
  • 17-OH PREG
  • 17-OH Pregnenolone
  • 3β,17-Dihydroxypregn-5-en-20-one
  • 3β,17α-Dihydroxypregn-5-en-20-one
  • 3-beta,17-dihydroxypregn-5-en-20-one
  • 3-beta,17-alpha-dihydroxypregn-5-en-20-one
  • Hydroxypregnenolone
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE 3H ASSAY ASSAY CHARACTERISTICS
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE (1,2-3 H)
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE 3H RIA KIT ASSAY CHARACTERISTICS
  • 17ALPHA-LPHA-HYDROXYPREGNENOLONE CRYSTALLINE
  • Pregn-5-en-20-one, 3,17-dihydroxy-, (3β)-
  • 17α-Hydroxypregnenolone,3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one
  • NSC 63853
  • 3β,17α-Dihydroxy-5-pregnen-20-one
  • 5-Pregnene-3β,17α-diol-20-one
  • 17α-Hydroxypregnenolone solution
  • 17α-hydroxypregnenolone solution,100ppm
  • 3B 17A-DIHYDROXYPREGN-5-EN-20-ONE
  • 3BETA,17ALPHA-DIHYDROXY-DELTA5-PREGNEN-20-ONE
  • 3BETA,17ALPHA-DIHYDROXY-5-PREGNEN-20-ONE
  • 3-BETA,17-DIHYDROXY-5-PREGNEN-3-ONE
  • 5-PREGNENE-3BETA,17ALPHA-DIOL-20-ONE
  • 5-PREGNEN-3-BETA, 17-DIOL-20-ONE
  • 5-PREGNEN-3BETA-17A-DIOL-20-ONE
  • 5-PREGNEN-3BETA,17ALPHA-DIOL-20-ONE
  • 17-dihydroxy-(3-beta)-pregn-5-en-20-on
  • 3-beta,17-dihydroxy-pregn-5-en-20-on
  • HYDROXYPREGNENOLONE, 17A-
  • 17A-HYDROXYPREGENOLONE
  • 17A-HYDROXY PREGNENOLONE
  • 17ALPHA-HYDROXYPREGNENOLONE
  • 17-HYDROXYPREGNENOLONE
  • 17alpha-Hydroxypregnenolone-20,21-13C2,16,16-d2
  • 17α-Hydroxypregnenolone
  • 3b,17-Dihydroxy-5-pregnen-20-one
  • 17α-Hydroxypregnenolone (Solution)
  • "17A-HYDROXY PREGNENOLONE 13C2,D2"
  • Inhibitor,17a Hydroxypregnenolone,Endogenous Metabolite,17aHydroxypregnenolone,inhibit,17a-Hydroxypregnenolone
  • Dronedarone HCl-d6
  • 5-PREGNEN-3β, 17-DIOL-20-ONE
  • 387-79-1
  • Steroids