17ALPHA-HYDROXYPREGNENOLONE

Product Name: 17ALPHA-HYDROXYPREGNENOLONE
CAS No.: 387-79-1
Chemical Name: 17ALPHA-HYDROXYPREGNENOLONE
Synonyms: NSC 63853;17-OH PREG;17alpha-Hydroxy;17-OH Pregnenolone;Dronedarone HCl-d6;Hydroxypregnenolone;17a-Hydroxypregnolone;17A-HYDROXYPREGENOLONE;17-HYDROXYPREGNENOLONE;17α-Hydroxypregnenolone
CBNumber: CB3175435
Molecular Formula: C21H32O3
Formula Weight: 332.48
MOL File: 387-79-1.mol

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17ALPHA-HYDROXYPREGNENOLONE Property

Melting point:: 273℃
Flash point:: 9℃
storage temp.: -20°C
solubility: Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form: Solid
Boiling point:: 478.4±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
pka: 13.02±0.70(Predicted)
color: White to Off-White
InChI: InChI=1S/C21H32O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4,15-18,23-24H,5-12H2,1-3H3/t15-,16+,17-,18-,19-,20-,21-/m0/s1
InChIKey: JERGUCIJOXJXHF-TVWVXWENSA-N
SMILES: C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](CC4=CC[C@@]3([H])[C@]1([H])CC[C@]2(O)C(=O)C)O)C
CAS DataBase Reference: 387-79-1(CAS DataBase Reference)

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol
WGK Germany: 3
RTECS: TU5548000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5002
Product name: 17α-Hydroxypregnenolone
Packaging: 5g
Price: $578
Updated: 2025/07/31

Sigma-Aldrich

Product number: H-105
Product name: 17α-Hydroxypregnenolone solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $131
Updated: 2025/07/31

Sigma-Aldrich

Product number: S518034
Product name: 3BETA,17ALPHA-DIHYDROXYPREGN-5-EN-20-ONE
Purity: AldrichCPR
Packaging: 250MG
Price: $28.6
Updated: 2022/05/15

Sigma-Aldrich

Product number: R199400
Product name: 3-BETA,17-ALPHA-DIHYDROXYPREGN-5-EN-20-ONE
Purity: AldrichCPR
Packaging: 1MG
Price: $28.6
Updated: 2022/05/15

Cayman Chemical

Product number: 29181
Product name: 17α-hydroxy Pregnenolone
Packaging: 100mg
Price: $44
Updated: 2024/03/01

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17ALPHA-HYDROXYPREGNENOLONE Chemical Properties,Usage,Production

Description

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

Uses

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

General Description

17α-hydroxypregnenolone is a derived from pregnenolone.

Biochem/physiol Actions

17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.

IC 50

Human Endogenous Metabolite

References

[1] ELYSE M PETRUNAK. Structures of human steroidogenic cytochrome P450 17A1 with substrates.[J]. The Journal of Biological Chemistry, 2014, 289 47: 32952-32964. DOI: 10.1074/jbc.m114.610998
[2] JEAN FIET . Plasma 17-OH pregnenolone: comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine[J]. Steroids, 2001, 66 2: Pages 81-86. DOI: 10.1016/s0039-128x(00)00207-5

17ALPHA-HYDROXYPREGNENOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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17ALPHA-HYDROXYPREGNENOLONE Suppliers

China 79 Europe 2 Germany 3 India 1 Poland 1 Switzerland 1 United Kingdom 7 United States 26 Global 120

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387-79-1, 17ALPHA-HYDROXYPREGNENOLONERelated Search:

17alpha-Hydroxy

(3b)-3,17-dihydroxy-Pregn-5-en-20-one

17a-Hydroxypregnolone

17ALPHA-LPHA-HYDROXYPREGNENOLONE

5-Pregnen-3b,17-dihydroxy-3-one

3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one

17-OH PREG

17-OH Pregnenolone

3β,17-Dihydroxypregn-5-en-20-one

3β,17α-Dihydroxypregn-5-en-20-one

3-beta,17-dihydroxypregn-5-en-20-one

3-beta,17-alpha-dihydroxypregn-5-en-20-one

Hydroxypregnenolone

17ALPHA-LPHA-HYDROXYPREGNENOLONE 3H ASSAY ASSAY CHARACTERISTICS

17ALPHA-LPHA-HYDROXYPREGNENOLONE (1,2-3 H)

17ALPHA-LPHA-HYDROXYPREGNENOLONE 3H RIA KIT ASSAY CHARACTERISTICS

17ALPHA-LPHA-HYDROXYPREGNENOLONE CRYSTALLINE

Pregn-5-en-20-one, 3,17-dihydroxy-, (3β)-

17α-Hydroxypregnenolone,3β,17α-Dihydroxy-5-pregnen-20-one, 5-Pregnene-3β,17α-diol-20-one

NSC 63853

3β,17α-Dihydroxy-5-pregnen-20-one

5-Pregnene-3β,17α-diol-20-one

17α-Hydroxypregnenolone solution

17α-hydroxypregnenolone solution,100ppm

3B 17A-DIHYDROXYPREGN-5-EN-20-ONE

3BETA,17ALPHA-DIHYDROXY-DELTA5-PREGNEN-20-ONE

3BETA,17ALPHA-DIHYDROXY-5-PREGNEN-20-ONE

3-BETA,17-DIHYDROXY-5-PREGNEN-3-ONE

5-PREGNENE-3BETA,17ALPHA-DIOL-20-ONE

5-PREGNEN-3-BETA, 17-DIOL-20-ONE

5-PREGNEN-3BETA-17A-DIOL-20-ONE

5-PREGNEN-3BETA,17ALPHA-DIOL-20-ONE

17-dihydroxy-(3-beta)-pregn-5-en-20-on

3-beta,17-dihydroxy-pregn-5-en-20-on

HYDROXYPREGNENOLONE, 17A-

17A-HYDROXYPREGENOLONE

17A-HYDROXY PREGNENOLONE

17ALPHA-HYDROXYPREGNENOLONE

17-HYDROXYPREGNENOLONE

17alpha-Hydroxypregnenolone-20,21-13C2,16,16-d2

17α-Hydroxypregnenolone

3b,17-Dihydroxy-5-pregnen-20-one

17α-Hydroxypregnenolone (Solution)

"17A-HYDROXY PREGNENOLONE 13C2,D2"

Inhibitor,17a Hydroxypregnenolone,Endogenous Metabolite,17aHydroxypregnenolone,inhibit,17a-Hydroxypregnenolone

Dronedarone HCl-d6

5-PREGNEN-3β, 17-DIOL-20-ONE

17α-Hydroxypregnenolone-[13C2,d2] in Methanol

17α-Hydroxypregnenolone in Methanol

3β,17-Dihydroxy-5-Pregnen-3-One

17a-Hydroxypregnenolone, 10 mM in DMSO

D2-17α-Hydroxypregnenolone

387-79-1

Steroids