Z-TYR(BZL)-OH
- Product Name
- Z-TYR(BZL)-OH
- CAS No.
- 16677-29-5
- Chemical Name
- Z-TYR(BZL)-OH
- Synonyms
- Z-TYR(BZL)-OH;CBZ-TYR(BZL)-OH;Z-L-Tyr(Bzl)-OH;Cbz-L-Tyr(Bzl)-OH;CBZ-O-BENZYL-L-TYR;Z-TYROSINE(BZL)-OH;Z-O-BENZYL-L-TYROSINE;CBZ-O-BENZYL-L-TYROSINE;Z-O-Benzyl-L-tyrosine, 98%+;N-ALPHA-CBZ-O-BENZYL-L-TYROSINE
- CBNumber
- CB3175990
- Molecular Formula
- C24H23NO5
- Formula Weight
- 405.44
- MOL File
- 16677-29-5.mol
Z-TYR(BZL)-OH Property
- Boiling point:
- 624.4±55.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Solid
- pka
- 2.98±0.10(Predicted)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- E207
- Product name
- Z-Tyr(Bzl)-OH
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 02269
- Product name
- Z-O-benzyl-L-tyrosine,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 1G
- Price
- $17.36
- Updated
- 2021/12/16
- Product number
- 02269
- Product name
- Z-O-benzyl-L-tyrosine,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 5G
- Price
- $48.22
- Updated
- 2021/12/16
- Product number
- FB47320
- Product name
- Z-O-benzyl-L-tyrosine
- Packaging
- 5G
- Price
- $79.1
- Updated
- 2021/12/16
- Product number
- 093615
- Product name
- Z-Tyr(Bzl)-OH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
Z-TYR(BZL)-OH Chemical Properties,Usage,Production
Synthesis
16652-64-5
501-53-1
86827-18-1
General procedure for the synthesis of the compound (CAS: 86827-18-1) from O-benzyl-L-tyrosine and benzyl chloroformate: (S)-O-benzyl-tyrosine (8.14 g, 30 mmol) was dissolved in THF (60 mL) and cooled to 0 °C. Subsequently, an aqueous solution of NaOH (3 g, 75 mmol) was added (60 mL). A solution of benzyl chloroformate (4.65 mL, 5.63 g, 33 mmol) in THF (30 mL) was slowly added dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, then gradually warmed to room temperature and continued stirring overnight. After the reaction was completed, water (50 mL) was added and the pH was adjusted to 1-2 with 10% HCl, then the aqueous phase was extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed with brine (2 × 100 mL) and dried over Na2SO4. The solvent was removed by concentration under reduced pressure to give pure (S)-N-Benzyloxycarbonyl-O-benzyl-tyrosine (11.57 g, 95% yield) as a pale yellow solid, melting point: 128-130°C. The product could be used in the next reaction without further purification.1H NMR (400 MHz, CDCl3) δ: 2.85 (dd, J = 13.2, 8.4 Hz, 1H, CH2), 3.10 (dd, J = 13.2, 12.0 Hz, 1H, CH2), 4.43 (dd, J = 12.0, 8.4 Hz, 1H, CH). 4.80 (d, J = 12.4 Hz, 1H, CH2O), 4.82 (s, 2H, CH2O), 5.00 (d, J = 12.4 Hz, 1H, CH2O), 5.60 (d, J = 4.8 Hz, 1H, NH), 6.65-7.35 (m, 14H, ArH).13C NMR (100 MHz, CDCl3) δ : 36.9, 56.2, 66.8, 69.8, 114.8, 127.5, 127.83, 127.89, 127.93, 128.4, 128.5, 128.9, 130.3, 136.2, 137.0, 156.6, 157.7, 177.5. HRMS (ESI) C24H24NO5 [M + H ]+ m/z calculated value: 406.1649; measured value: 406.1641.
References
[1] Tetrahedron, 2014, vol. 70, # 34, p. 5197 - 5206
[2] Chemische Berichte, 1958, vol. 91, p. 542,546
[3] Monatshefte fuer Chemie, 1974, vol. 105, p. 1110 - 1135
[4] Tetrahedron, 2014, vol. 70, # 34, p. 5197 - 5206
Z-TYR(BZL)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Z-TYR(BZL)-OH Suppliers
- Tel
- --
- Fax
- --
- sales21@chemicalland21.com
- Country
- South Korea
- ProdList
- 6303
- Advantage
- 74
View Lastest Price from Z-TYR(BZL)-OH manufacturers
- Product
- Z-TYR(BZL)-OH 16677-29-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15
- Product
- Z-TYR(BZL)-OH 16677-29-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15