(+/-)12-HETE

Product Name: (+/-)12-HETE
CAS No.: 71030-37-0
Chemical Name: (+/-)12-HETE
Synonyms: (R)-12-HETE;(+/-)12-HETE;ZNHVWPKMFKADKW-VXBMJZGYSA-N;12-hydroxyeicosatetraenoicacid;(5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid;10,14-eicosatetraenoicacid,12-hydroxy-,(e,z,z,z)-8;(+/-)12-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;(+/-)12-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (E,Z,Z,Z)-;(5Z,8Z,10E,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid
CBNumber: CB3176331
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 71030-37-0.mol

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(+/-)12-HETE Property

Boiling point:: 487.7±45.0 °C(Predicted)
Density: 0.984±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
form: Liquid
pka: 4.75±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 34550
Product name: (±)12-HETE
Purity: ≥98%
Packaging: 25μg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 34550
Product name: (±)12-HETE
Purity: ≥98%
Packaging: 50μg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 34550
Product name: (±)12-HETE
Purity: ≥98%
Packaging: 100μg
Price: $255
Updated: 2024/03/01

Cayman Chemical

Product number: 34550
Product name: (±)12-HETE
Purity: ≥98%
Packaging: 250μg
Price: $565
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: LIP0000627
Product name: (+/-)12-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $505.54
Updated: 2021/12/16

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(+/-)12-HETE Chemical Properties,Usage,Production

Description

(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC₅₀ value of 40 nM.

Uses

12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

Definition

ChEBI: (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid is the (5Z,8Z,10E,14Z)-stereoisomer of 12-HETE. It has a role as a mouse metabolite. It is a conjugate acid of a 12-HETE(1-).

References

[1] Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838. DOI:10.2147/CMAR.S180334
[2] Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40. DOI:10.1016/j.jchromb.2014.03.015
[3] Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64. DOI:10.1523/JNEUROSCI.22-01-00257.2002

(+/-)12-HETE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)12-HETE Suppliers

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71030-37-0, (+/-)12-HETERelated Search:

12-HETE 10-11 reductase 12(S)-HETE-D8 (+/-)12-HETE (s)-12-hete 12(S),20-DIHETE 12(S)-HETE-[5,6,8,9,11,12,14,15-3H(N)]- 12(R)-HETE 12(S)-HPETE [1-14C] 12(S)-HPETE (+/-)12-HPETE

(+/-)12-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID

(+/-)12-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID

(+/-)12-HETE

10,14-eicosatetraenoicacid,12-hydroxy-,(e,z,z,z)-8

12-hydroxyeicosatetraenoicacid

(5E,8Z,10Z,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid

(5Z,8Z,10E,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid

(5Z,8Z,10E,14Z)-12-Hydroxyicosa-5,8,10,14-tetraenoic acid

(R)-12-HETE

5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (E,Z,Z,Z)-

(5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid

ZNHVWPKMFKADKW-VXBMJZGYSA-N

5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,14Z)-

12-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid, 100ug/ml in ethanol

71030-37-0