A 769662

ChemicalBook > CAS DataBase List > A 769662

Product Name: A 769662
CAS No.: 844499-71-4
Chemical Name: A 769662
Synonyms: CS-18;A 769662;A-769622;A-769662, >=98%;A-769662/A769662;A 769662 ISO 9001：2015 REACH;A 769662 (This product is unavailable in the U.S.);4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6;4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile;4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile
CBNumber: CB31871930
Molecular Formula: C20H12N2O3S
Formula Weight: 360.39
MOL File: 844499-71-4.mol

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A 769662 Property

Melting point:: 263 - 266oC
Boiling point:: 630.1±55.0 °C(Predicted)
Density: 1.56
Flash point:: 334.9℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form: solid
pka: 4.50±1.00(Predicted)
color: Beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11900
Product name: A-769662
Purity: ≥98%
Packaging: 5mg
Price: $69
Updated: 2024/03/01

Cayman Chemical

Product number: 11900
Product name: A-769662
Purity: ≥98%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 11900
Product name: A-769662
Purity: ≥98%
Packaging: 50mg
Price: $449
Updated: 2024/03/01

Tocris

Product number: 3336
Product name: A769662
Purity: ≥98%(HPLC)
Packaging: 50
Price: $899
Updated: 2021/12/16

Tocris

Product number: 3336
Product name: A769662
Purity: ≥98%(HPLC)
Packaging: 10
Price: $214
Updated: 2021/12/16

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A 769662 Chemical Properties,Usage,Production

Description

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC₅₀ = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr¹⁷². A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

Uses

A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Definition

ChEBI: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile is a member of biphenyls.

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .

storage

+4°C

References

1) Scott et al. (2008), Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes; Cell Biol., 15 1220 2) Cool et al. (2006), Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome; Cell Metab., 3 403 3) Zhou et al. (2009), Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase on 3T3-L1 adipogenesis; Biol. Pharm. Bull., 32?993 4) Vazquez-Martin et al. (2012) Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells; Cell Cycle, 11 974 5) Ducommun et al. (2014) Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662; Am. J. Physiol. Endocrinol. Metab., 306 E688

A 769662 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 769662 Suppliers

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View Lastest Price from A 769662 manufacturers

Dideu Industries Group Limited

Product: A 769662 844499-71-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile 844499-71-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

844499-71-4, A 769662Related Search:

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM BIO Glibenclamide (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE 2,2-diphenyl-1-picrylhydrazyl RUETASOLV BP 4103 - MIXTURE OF ISOMERES ISOPROPYLBIPHENYLS. FOR FURTHER DETAILS PLEASE INQUIRE AT MARKETING CONTACTS. SPECIALITY CHEMICALS 4,4'-Biphenol 3-PHENYLPHENOL 4-Phenylphenol BML-275 PD 0325901 BIRB 796 (Doramapimod) AICAR Ibrutinib CHIR-99021

A 769662

4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile

CS-18

6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-

A-769662/A769662

4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri

A-769622

A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

A-769662, >=98%

4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboni

4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6

4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile

A 769662 (This product is unavailable in the U.S.)

A 769662 ISO 9001：2015 REACH

4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

844499-71-4

C20H12N2O3S

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