ChemicalBook > CAS DataBase List > 2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
Uses- Product Name
- 2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
- CAS No.
- 16234-15-4
- Chemical Name
- 2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
- Synonyms
- EOS-60342;2-chloro-4-(4-Morpholinyl)-;4-(2-Chlorothieno[3,2-d]pyrimidin-4-yl);2-chloro-4-Morpholinothieno[3,2-d]pyriMidine;4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine;2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine;2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine;2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine-4;Thieno[3,2-d]pyriMidine, 2-chloro-4-(4-Morpholinyl)-
- CBNumber
- CB31872119
- Molecular Formula
- C10H10ClN3OS
- Formula Weight
- 255.72
- MOL File
- 16234-15-4.mol
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2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine Property
- Boiling point:
- 393.7±42.0 °C(Predicted)
- Density
- 1.463
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.82±0.40(Predicted)
- InChI
- InChI=1S/C10H10ClN3OS/c11-10-12-7-1-6-16-8(7)9(13-10)14-2-4-15-5-3-14/h1,6H,2-5H2
- InChIKey
- HKQMXHKNXRNUCF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(N2CCOCC2)=C2SC=CC2=N1
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- FC144248
- Product name
- 2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144248
- Product name
- 2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
AK Scientific
- Product number
- W3538
- Product name
- 2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144248
- Product name
- 2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144248
- Product name
- 2-Chloro-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
- Packaging
- 2g
- Price
- $522
- Updated
- 2021/12/16
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2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine Chemical Properties,Usage,Production
Uses
2-Chloro-4-(4-morpholino)thieno[3,2-D]pyrimidine is a pyrimidine derivative that can be used as a pharmaceutical and chemical intermediate.
Synthesis
110-91-8
16234-14-3
16234-15-4
The reaction was carried out with 2,4-dichlorothieno[3,2-d]pyrimidine (64) (8.68 g, 42.34 mmol) and morpholine (8.1 mL, 2.2 eq.) in methanol (150 mL) with stirring for 1 hour at room temperature. After completion of the reaction, the reaction mixture was filtered and washed sequentially with water and methanol to afford the target compound 2-chloro-4-(4-morpholinyl)thieno[3,2-D]pyrimidine (65) as a white solid (11.04 g, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.74 (4H, t, J = 4.9 Hz), 3.90 (4H, t, J = 4.9 Hz), 7.40 (1H, d, J = 5.6 Hz), 8.30 (1H, d, J = 5.6 Hz).
References
[1] Patent: WO2006/46031, 2006, A1. Location in patent: Page/Page column 29-30
[2] Patent: US2008/76768, 2008, A1. Location in patent: Page/Page column 7
[3] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 73
[4] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 133
[5] Patent: WO2008/73785, 2008, A2. Location in patent: Page/Page column 160
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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16234-15-4, 2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidineRelated Search:
2-(Chloromethyl)pyridine
Dichloroethane
Oxalyl chloride
2-Chlorobenzonitrile
4-(2-CHLORO-4-PYRIMIDINYL)MORPHOLINE
2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine
4-AMINO-2-CHLOROTHIENO[3,2-D]PYRIMIDINE