DGAT-3

Product Name: DGAT-3
CAS No.: 701232-20-4
Chemical Name: DGAT-3
Synonyms: DGAT-3;CS-120;T-863;T 863;trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid;trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl];trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-;2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid;Diglyceride acyltransferase,inhibit,acyl-CoA:cholesterol acyltransferase,T 863,T-863,T863,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,Diacylglycerol acyltransferase
CBNumber: CB31872285
Molecular Formula: C22H26N4O3
Formula Weight: 394.47
MOL File: 701232-20-4.mol

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DGAT-3 Property

Boiling point:: 616.6±55.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL (clear solution)
pka: 4.72±0.10(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0539
Product name: T863
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0539
Product name: T863
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $334.2
Updated: 2024/03/01

Cayman Chemical

Product number: 25807
Product name: T-863
Purity: ≥95%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 25807
Product name: T-863
Purity: ≥95%
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 25807
Product name: T-863
Purity: ≥95%
Packaging: 10mg
Price: $236
Updated: 2024/03/01

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DGAT-3 Chemical Properties,Usage,Production

Uses

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

to provide the opportunity to precisely control the DGAT inhibition
to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
to specifically block neutral?lipid synthesis?and lipid droplet formation in HT-1080 cells
to block lipid droplet (LD) formation

Biological Activity

diacylglycerol acyltransferase (dgat1) inhibitor

Biochem/physiol Actions

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

DGAT-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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DGAT-3 Suppliers

China 47 United States 14 Global 61

MedChemexpress LLC

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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BOC Sciences

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Aladdin Scientific

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Creative Enzymes

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MedChemExpress

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701232-20-4, DGAT-3Related Search:

N,N-Dimethylaniline trans-4-Aminocyclohexanol

DGAT-3

Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-

trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid

trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid

2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid

T-863;T 863

CS-120

trans-Cyclohexaneacetic-acid,-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]

Diglyceride acyltransferase,inhibit,acyl-CoA:cholesterol acyltransferase,T 863,T-863,T863,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,Diacylglycerol acyltransferase

701232-20-4