ChemicalBook > CAS DataBase List > Eurycomanone

Eurycomanone

Product Name: Eurycomanone
CAS No.: 84633-29-4
Chemical Name: Eurycomanone
Synonyms: NSC 339187;eurysanone;EURYCOMANONE;pasakbumin-a;tonkat ali extract;Eurycoma longifolia;Eurycomanone (~90%);Broad tassel ketone;EurycomalongifoliaJack;Eurycomanone - Bio-X ?
CBNumber: CB3189926
Molecular Formula: C20H24O9
Formula Weight: 408.4
MOL File: 84633-29-4.mol

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Eurycomanone Property

Melting point:: 273-285℃ (methanol ethyl ether )
Boiling point:: 669.5±55.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form: Solid
pka: 11.29±0.70(Predicted)
color: Off-White to Pale Beige
biological source: plant
InChIKey: RRXCMOJNEHOTBC-OHYAWSEYNA-N
SMILES: [C@]123CO[C@@]4(O)[C@H](O)C(=C)[C@]1(O)[C@@H](O)C(=O)O[C@]2([H])C[C@@]1([H])C(C)=CC(=O)[C@@H](O)[C@]1(C)[C@]34[H].O.O |&1:0,3,5,9,11,16,19,26,28,30,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3374
Product name: Eurycomanone
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $66.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3374
Product name: Eurycomanone
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

TRC

Product number: E939010
Product name: Eurycomanone(~90%)
Packaging: 10mg
Price: $205
Updated: 2021/12/16

Usbiological

Product number: 300262
Product name: Eurycomanone
Packaging: 5mg
Price: $490
Updated: 2021/12/16

Usbiological

Product number: 011891
Product name: Eurycomanone
Packaging: 1mg
Price: $1522
Updated: 2021/12/16

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Eurycomanone Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tongkat Ali.

Uses

Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.

Definition

ChEBI: A quassinoid isolated from Eurycoma longifolia and has been shown to exhibit antineoplastic and antimalarial activties.

Manufacturing Process

The extraction and purification process of eurycomanone in a kind of Tongkat Ali plant:
The preparation of the first medicinal extract: Tongkat Ali tree root meal is gone out eurycomanone with solvent extraction, extracting solution, concentrating under reduced pressure obtains Tongkat Ali medicinal extract.
Second degreasing: by Tongkat Ali medicinal extract with petroleum ether extraction, leaves standstill, layering. The low-pole compositions include removing fat-soluble pigment.
3rd extracting and separating: the medicinal extract after petroleum ether degreasing with extraction into ethyl acetate, obtain the ethyl acetate solution of eurycomanone.
4th pillar layer separation: the ethyl acetate solution of eurycomanone is separated with silica gel column chromatography, obtaining the elutriant containing eurycomanone.
5th decolouring: the composition containing eurycomanone is activated carbon decolorizing.
6th concentrates and crystallization: the destainer concentrates under reduced pressure of eurycomanone, and crystallization obtains the crude product eurycomanone.
7th purifying: add sherwood oil in crude product eurycomanone, then drip a little ethyl acetate, by the impurity pigment washing removing on crystallisate, obtain the xln of white.
8th filters, dry: by the vacuum-drying of eurycomanone xln.

Biological Activity

Eurycomanone, the major quassinoid in the E. longifolia root extract, significantly increased testosterone production in a dose-dependent manner at 0.1, 1.0 and 10.0 μM (p < 0.05). It enhanced testosterone steroidogenesis at the rat testicular Leydig’s cells by inhibiting the aromatase conversion of testosterone to oestrogen and may also involve phosphodiesterase inhibition at a high concentration. Also, standardized extracts of E. longifolia Jack containing a high concentration of quassinoids (20% eurycomanone and 4% of 13α,21-dihydroeurycomanone) may have potential anti-estrogenic effects[1].

References

[1] Shaheed Ur Rehman, Hye Hyun Yoo, Kevin Choe. “Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology.” Molecules 21 3 (2016): 331.

Eurycomanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Eurycomanone manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Eurycomanone 84633-29-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-27

BINBO BIOLOGICAL CO.,LTD

Product: Tongkat Ali Extract 84633-29-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 1-10%
Supply Ability: 1000 kg
Release date: 2024-11-21

Dingwang Technology (Wuhan) Co., Ltd.

Product: Eurycomanone/Tongkat Ali Extract 84633-29-4
Price: US $0.00-0.00/gram
Min. Order: 10gram
Purity: 99% HPLC
Supply Ability: 10 gram
Release date: 2024-05-06

84633-29-4, EurycomanoneRelated Search:

EURYCOMANONE ELEUTHEROSIDE E1 St.-John's-wort, Hypericum perforatum, ext. Garcinia cambogia extract Seco-isolariciresinol diglucoside Mangostin Macleaya cordata extract Ginseng extract Eurycoma longifolia powder extract Centella asiatica extract (-)-DIHYDROCARVYL ACETATE (R)-BETA-HYDROXY-BETA-METHYL-DELTA-VALEROLACTONE 2-ISOBUTYL-4-HYDROXY-4-METHYLTETRAHYDROPYRAN DIHYDROCARVEOL OCTAHYDROCOUMARIN (1-Hydroxy-cyclohexyl)-acetic acid ailanthone delta-Dodecalactone

EURYCOMANONE

11,2o-epoxy-1,11,12,14,15-pentahydroxy-13(21)-diene-(1-picrasa-16-dione

11-beta,12-alpha,15-beta)-betdihydrate

pasakbumin-a

11β,20-Epoxy-1β,11,12α,14,15β-pentahydroxypicrasa-3,13(21)-diene-2,16-dione

NSC 339187

(1beta,8xi,11beta,12alpha,15beta)-1,11,12,14,15-pentahydroxy-11,20-epoxypicrasa-3,13(21)-diene-2,16-dione

Eurycoma longifolia

Eurycomanone, 98%, from Eurycoma longifolia

Extract of Orion nigrum

EurycomalongifoliaJack

Eurycomanone (Synonyms: Pasakbumin A)

Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12,14,15-pentahydroxy-, (1b,11b,12a,15b)-

Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)-

Extract of amaryllis asiatica l

Eurycomanone (~90%)

Eurycomanone (Pasakbumin A)

tonkat ali extract

Broad tassel ketone

eurysanone

Eurycomanone/Tongkat Ali Extract

Eurycoma longifolia 100:1

(1R,2R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-Pentahydroxy-8,11a-dimethyl-3-methylene-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione

EURYCOMANONE, 10 mM in DMSO

Eurycomanone - Bio-X ?

84633-29-4

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