ChemicalBook > CAS DataBase List > N-(4-butylphenyl)-4-fluorobenzenesulfonamide

N-(4-butylphenyl)-4-fluorobenzenesulfonamide

Product Name: N-(4-butylphenyl)-4-fluorobenzenesulfonamide
CAS No.: 346692-04-4
Chemical Name: N-(4-butylphenyl)-4-fluorobenzenesulfonamide
Synonyms: DC260126;DC260126 ，S0742;DC260126 >=98% (HPLC);DC260126;DC-260126 ;DC 260126;N-(4-butylphenyl)-4-fluorobenzenesulfonamide;Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro-;stress,DC260126,DC-260126,FFAR,Inhibitor,insulin,inhibit,secretion,Apoptosis,DC 260126,Free Fatty Acid Receptor,phosphorylation,elevation,Ca2+
CBNumber: CB31968223
Molecular Formula: C16H18FNO2S
Formula Weight: 307.38
MOL File: 346692-04-4.mol

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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Property

storage temp.: -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1050
Product name: DC260126
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1050
Product name: DC260126
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $317
Updated: 2022/05/15

Cayman Chemical

Product number: 19388
Product name: DC260126
Purity: ≥98%
Packaging: 5mg
Price: $46
Updated: 2024/03/01

Cayman Chemical

Product number: 19388
Product name: DC260126
Purity: ≥98%
Packaging: 50 mg
Price: $276
Updated: 2024/03/01

Cayman Chemical

Product number: 19388
Product name: DC260126
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2023/01/06

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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Chemical Properties,Usage,Production

Description

DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca²⁺ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC₅₀ values of 6.28, 5.96, 7.07, and 4.58 μM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.

Uses

DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively)[1]. DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis[2].

storage

Store at -20°C

References

[1] HUI HU . A novel class of antagonists for the FFAs receptor GPR40[J]. Biochemical and biophysical research communications, 2009, 390 3: Pages 557-563. DOI:10.1016/j.bbrc.2009.10.004
[2] XIAODONG ZHANG . DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats[J]. Biomedicine & Pharmacotherapy, 2010, 64 9: Pages 647-651. DOI:10.1016/j.biopha.2010.06.008
[3] PENG SUN. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.[J]. PLoS ONE, 2013: e66744. DOI:10.1371/journal.pone.0066744
[4] JINWEI WU. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis[J]. Journal of cellular biochemistry, 2011, 113 4: 1152-1158. DOI:10.1002/jcb.23450

N-(4-butylphenyl)-4-fluorobenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-butylphenyl)-4-fluorobenzenesulfonamide Suppliers

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346692-04-4, N-(4-butylphenyl)-4-fluorobenzenesulfonamideRelated Search:

BI 6015 (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE ISX 9 Pioglitazone hydrochloride Deionized water 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

N-(4-butylphenyl)-4-fluorobenzenesulfonamide

DC260126

DC260126;DC-260126 ;DC 260126

Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro-

DC260126 >=98% (HPLC)

stress,DC260126,DC-260126,FFAR,Inhibitor,insulin,inhibit,secretion,Apoptosis,DC 260126,Free Fatty Acid Receptor,phosphorylation,elevation,Ca2+

DC260126 ，S0742

346692-04-4