Boc-N-methyl-L-leucine
- Product Name
- Boc-N-methyl-L-leucine
- CAS No.
- 53363-89-6
- Chemical Name
- Boc-N-methyl-L-leucine
- Synonyms
- Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE
- CBNumber
- CB3197622
- Molecular Formula
- C12H23NO4
- Formula Weight
- 245.32
- MOL File
- 53363-89-6.mol
Boc-N-methyl-L-leucine Property
- Melting point:
- 55-60 °C
- Boiling point:
- 338.2±21.0 °C(Predicted)
- Density
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 4.04±0.21(Predicted)
- optical activity
- [α]20/D 36±2°, c = 1% in methylene chloride
- BRN
- 2373250
- InChI
- InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
- InChIKey
- YXJFAOXATCRIKU-VIFPVBQESA-N
- SMILES
- C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
- CAS DataBase Reference
- 53363-89-6(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- HS Code
- 2924 19 00
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.53083
- Product name
- Boc-N-Me-Leu-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $132
- Updated
- 2023/01/07
- Product number
- 15446
- Product name
- Boc-N-Me-Leu-OH
- Purity
- ≥99.0% (sum of enantiomers, TLC)
- Packaging
- 5g
- Price
- $360
- Updated
- 2023/01/07
- Product number
- 264714
- Product name
- Boc-N-methyl-L-leucine
- Packaging
- 2g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- 236540
- Product name
- Boc-N-methyl-L-leucine 98+%
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FB47462
- Product name
- Boc-N-methyl-L-leucine
- Packaging
- 25g
- Price
- $180
- Updated
- 2021/12/16
Boc-N-methyl-L-leucine Chemical Properties,Usage,Production
Description
Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
Uses
Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
Biological Activity
Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.
References
https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay
Boc-N-methyl-L-leucine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-N-methyl-L-leucine manufacturers
- Product
- Boc-N-Me-L-Leu-OH 53363-89-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-09-27
- Product
- BOC-N-Me-leu-OH 53363-89-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-21