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Boc-N-methyl-L-leucine

Product Name
Boc-N-methyl-L-leucine
CAS No.
53363-89-6
Chemical Name
Boc-N-methyl-L-leucine
Synonyms
Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE
CBNumber
CB3197622
Molecular Formula
C12H23NO4
Formula Weight
245.32
MOL File
53363-89-6.mol
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Boc-N-methyl-L-leucine Property

Melting point:
55-60 °C
Boiling point:
338.2±21.0 °C(Predicted)
Density 
1.053±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
4.04±0.21(Predicted)
form 
Solid
color 
White to off-white
optical activity
[α]20/D 36±2°, c = 1% in methylene chloride
BRN 
2373250
InChI
InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
InChIKey
YXJFAOXATCRIKU-VIFPVBQESA-N
SMILES
C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference
53363-89-6(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
2924 19 00
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53083
Product name
Boc-N-Me-Leu-OH
Purity
Novabiochem?
Packaging
5G
Price
$132
Updated
2023/01/07
Sigma-Aldrich
Product number
15446
Product name
Boc-N-Me-Leu-OH
Purity
≥99.0% (sum of enantiomers, TLC)
Packaging
5g
Price
$360
Updated
2023/01/07
Usbiological
Product number
264714
Product name
Boc-N-methyl-L-leucine
Packaging
2g
Price
$333
Updated
2021/12/16
Usbiological
Product number
236540
Product name
Boc-N-methyl-L-leucine 98+%
Packaging
1g
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB47462
Product name
Boc-N-methyl-L-leucine
Packaging
25g
Price
$180
Updated
2021/12/16
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Boc-N-methyl-L-leucine Chemical Properties,Usage,Production

Description

Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.

Uses

Boc-N-methyl-L-leucine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Biological Activity

Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.

References

https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay

Boc-N-methyl-L-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-methyl-L-leucine Suppliers

China 148 France 1 Germany 3 India 1 Japan 3 Switzerland 2 United Kingdom 4 United States 20 Global 182
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Email
inquiry@watanabechem.co.jp
Country
Japan
ProdList
1918
Advantage
50
Kokusan Chemical Co., Ltd.
Tel
--
Fax
--
Email
tech@kokusan-chem.co.jp
Country
Japan
ProdList
1658
Advantage
51
Watanabe Chemical Industries, Ltd.
Tel
--
Fax
--
Country
Japan
ProdList
4811
Advantage
42
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View Lastest Price from Boc-N-methyl-L-leucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-N-Me-L-Leu-OH 53363-89-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Sichuan Jiaying Lai Technology Co.,LTD
Product
BOC-N-Me-leu-OH 53363-89-6
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-21

53363-89-6, Boc-N-methyl-L-leucineRelated Search:

L-Leucine N-CARBOBENZOXY-DL-LEUCINE Methylparaben Thiophanate-methyl BOC-L-Leucine Boc-Aib-OH L-tert-Leucine Bensulfuron methyl Methyl acrylate N-Carbobenzyloxyglycine Kresoxim-methyl Methyl BOC-GLY-LEU-OH FMOC-ARG(ME,PBF)-OH N-Boc-L-trans-4,5-Methanoproline BOC-D-ALLO-ILE-OH BOC-D-TYR(ET)-OH FMOC-CHA-OH

  • N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
  • N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE
  • N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
  • N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE
  • BOC-BETA-TBU-ALANINE
  • BOC-BETA-TBU-ALA-OH
  • BOC-BETA-T-BUTYL-L-ALANINE
  • BOC-ALA(TBU)-OH
  • BOC-N-ME-LEUCINE
  • BOC-N-ME-LEU-OH
  • BOC-N-METHYL-L-LEUCINE
  • BOC-N-METHYL-L-LEU-OH
  • BOC-MELEU-OH
  • BOC-NEOPENTYLGLYCINE
  • BOC-(NEOPENTYL)GLY-OH
  • BOC-N-ALPHA-METHYL-L-LEUCINE
  • BOC-L-BETA-T-BUTYLALANINE
  • BOC-LEU(ME)-OH
  • BOC-L-NEOPENTYLGLYCINE
  • BOC-L-MELEU-OH
  • BOC-T-BUTYL-L-ALANINE
  • N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-LEUCINE
  • DANSYL-L-GLUTAMIC ACID BIS(CYCLOHEXYLAMMONIUM)
  • NALPHA-tert-Butoxycarbonyl-N-methyl-L-leucine
  • N-tert-Butyloxycarbonyl-N-methyl-L-leucine
  • N-(tert-butoxycarbonyl)-N-methyl-L-leucine
  • L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-
  • (S)-2-((tert-butoxycarbonyl)(Methyl)aMino)-4-Methylpentanoic acid
  • Tyr(Me)
  • Boc-N-Me-L-Leu-OH
  • Boc-<I>N</I>-Me-Leu-OH
  • Boc-N-Methyl Leucine
  • Boc-N-methyl-L-leucine98+%
  • N-α-t-butoxycarbonyl-β-t-butyl-L-alanine
  • (Tert-Butoxy)Carbonyl N-Me-Leu-OH
  • (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoic acid
  • (2S)-4-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid
  • Boc-N-L-methylleucine
  • Boc-N-methyl-L-leucine USP/EP/BP
  • 2-((TERT-BUTOXYCARBONYL)(METHYL)AMINO)-4-METHYLPENTANOIC ACID
  • N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-leucine
  • N-BOC-N-Methyl-L-leucine
  • BOC-N-methyl tert leucine
  • 53363-89-6
  • Peptide Synthesis
  • N-Methyl Amino Acids
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • amino acids
  • Amino Acid Derivatives
  • N-Methyl Amino Acids