Caryophyllene oxide

Product Name: Caryophyllene oxide
CAS No.: 1139-30-6
Chemical Name: Caryophyllene oxide
Synonyms: (-)-CARYOPHYLLENE OXIDE;(-)-EPOXYCARYOPHYLLENE;Caryophylene oxide;Caryophyllene epoxide;Caryophyllene oxyde;(-)-beta-Caryophyllene epoxide;caryophyleneoxide;CARYOPHYLLENEPOXID;5-oxatricyclo(8.20.0(4,6))dodecane,4,12,12-trimethyl-9-methylene-,(1r,4r,6r,1;0s)-
CBNumber: CB3199893
Molecular Formula: C15H24O
Formula Weight: 220.35
MOL File: 1139-30-6.mol

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Caryophyllene oxide Property

Melting point:: 62-63 °C(lit.)
Boiling point:: 301.3°C (rough estimate)
Density: 0.96
refractive index: 1.4956
FEMA: 4085 | BETA-CARYOPHYLLENE OXIDE
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Crystalline Powder
color: White
Odor: at 100.00 %. sweet fresh dry woody spicy
Odor Type: woody
biological source: synthetic
optical activity: [α]20/D 71±1°, c = 2% in chloroform
Water Solubility: insoluble in water
JECFA Number: 1575
BRN: 148213
LogP: 4.57
EPA Substance Registry System: 5-Oxatricyclo[8.2.0.04,6]dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)- (1139-30-6)

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26
WGK Germany: 2
RTECS: RP5530000
F: 1-10
HS Code: 29109000
Hazardous Substances Data: 1139-30-6(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W509647
Product name: (−)-Caryophyllene oxide
Purity: 95%
Packaging: 1 unit
Price: $56.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: W509647
Product name: (−)-Caryophyllene oxide
Purity: 95%
Packaging: 1 unit
Price: $56.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: W408588
Product name: (−)-Caryophyllene oxide
Purity: natural (US), ≥95%, FG
Packaging: 1 unit
Price: $58
Updated: 2025/07/31

Sigma-Aldrich

Product number: W408588
Product name: (−)-Caryophyllene oxide
Purity: natural (US), ≥95%, FG
Packaging: 1 unit
Price: $58
Updated: 2025/07/31

Sigma-Aldrich

Product number: W408588
Product name: (−)-Caryophyllene oxide
Purity: natural (US), ≥95%, FG
Packaging: 100G
Price: $302
Updated: 2025/07/31

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Caryophyllene oxide Chemical Properties,Usage,Production

Chemical Properties

Caryophyllene oxide is a Colorless or white crystalline powder that has a woody, slightly ambergris-like odor, can be prepared by treatment of β-caryophyllene with organic peracids.

Occurrence

Reported found in Nepeta betonicifolia C.A. Meyer oil Turkey (39.20%), geranium rose-scented oil (Pelargonium spp.) Cuba (14.70%), melissa oil (9.99%), guava leaf oil Cuba (8.20%), etc.

Uses

β-Caryophyllene Epoxide, and its derivatives has shown to have microbial transformation and butyrylcholinesterase inhibitory activity. It is also the main active constituent of essential oils obtained from various plants, used for flavoring and fragrances.

Definition

ChEBI: Caryophyllene oxide is an epoxide，a natural product found in Cupania cinerea. It has a role as a metabolite.

Aroma threshold values

Medium strength odor, woody type.

Biological Activity

β-caryophyllene oxide is a potent anti-cancer agent which also exerts antioxidant, anti-inflammatory, and antiviral properties. It is a strong inhibitor of drug-metabolizing enzyme cytochromes P4503A (CYP3A) activities both in r at and human hepatic microsomes. BCPO also exerts analgesic, antifungal, antibacterial, and genoprotective activities.

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Purify the oxide by TLC on silica gel with EtOAc/pet ether (b 60-80o) (15:85), and recrystallise it from MeOH or *C6H6. [NMR: Warnhoff Can J Chem 42 1664 1964, Ramage & Whitehead J Chem Soc 4336 1954, Beilstein 17 IV 392.]

Caryophyllene oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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Caryophyllene oxide Suppliers

Belgium 1 China 136 Germany 5 India 14 Italy 1 Japan 2 Spain 1 Switzerland 3 United Kingdom 2 United States 20 Global 185

Shanghai Luofa Biochemical Technology Co., Ltd.

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Wuhan xinyangruihe Chemical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
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Email: market03@meryer.com
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Chembest Research Laboratories Limited

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Email: sales@BioChemBest.com
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Beijing HwrkChemical Technology Co., Ltd

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Syntechem Co.,Ltd

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Sinopharm Chemical Reagent Co,Ltd.

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Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
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BioBioPha Co., Ltd.

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View Lastest Price from Caryophyllene oxide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: CARYOPHYLLENE OXIDE 1139-30-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 MT
Release date: 2024-11-14

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Caryophyllene Oxide 1139-30-6
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-02

Shandong Deshang Chemical Co., Ltd.

Product: CARYOPHYLLENE OXIDE 1139-30-6
Price: US $16.00-10.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 10 tons
Release date: 2024-06-19

1139-30-6, Caryophyllene oxideRelated Search:

alpha-Bisabolol Carbomer Ethanol Glycerol Salicylic acid Citric acid Centella asiatica whole plant Caryophyllene oxide β-Caryophyllene Dodecane ALPHA-CARYOPHYLLENE Methyl oleanolate (R)-(+)-1,2-EPOXY-9-DECENE Dihydromyrcenol 1,2-EPOXY-5-HEXENE (R)-(+)-1 2-EPOXYUNDECANE 97 CARYOPHYLLENE OXIDE(RG) SODIUM OLEANOLATE

(-)-5-Oxatricyclo[8.2.0.0(4,6)]dodecane,4,12,12-trimethyl-9-methylene-, [1R-(1R*,4R*,6R*,10S*)]-

(-)-beta-Caryophyllene epoxide

caryophyleneoxide

Caryophyllene epoxide

Caryophyllene oxyde

caryophylleneepoxide

(1R,4R,6R,10S)-9-METHYLENE-4,12,12-TRIMETHYL-5-OXATRICYCLO[8.2.0.0(4,6)]DODECANE

(-)-EPOXYCARYOPHYLLENE

(-)-CARYOPHYLLENE OXIDE

CARYOPHYLLENE OXIDE

caryophylleneoxide,(1R,4R,6R,10S)-4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.0]4,6)]dodecane

5-Oxatricyclo8.2.0.04,6dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

(1R-(1R*,4R*,6R*,10S*))-4,12,12-Trimethyl-9-methylen-5-oxatricyclo(8.2.0.04,6)dodecan

CARYOPHYLLENEPOXID

(-)-Epoxycaryophyllene, (1R,4R,6R,10S)-9-Methylene-4,12,12-trimethyl-5-oxatricyclo[8.2.0.04,6]dodecane

(1R,4R,6R,10S)-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[8.2.0.04,6]dodecane

(1R,5S,8R,11R)-4-Methylene-7,7,11-trimethyl-12-oxatricyclo[9.1.0.05,8]dodecane

(1β,4R,5R,9α)-4,11,11-Trimethyl-8-methylene-4,5-epoxybicyclo[7.2.0]undecane

(-)-Caryophyllene oxide,97%

(-)-CARYOPHYLLENE OXIDE 95%

CARYOPHYLLENE OXIDE TECH. 90%

CARYOPHYLLENE OXIDE 95+%

(-)-beta-caryophylleneepoxid

(-)-beta-caryophylleneepoxide

(-)-Epoxydihydrocaryophyllene

(1r-(1r*,4r*,6r*,10s*))-4,12,12-trimethyl-9-methylene-5-oxatricyclo(8.2.0.04,6)dodecane

(1r-(1r,4r,6r,10s))-4,12,12-trimethyl

(1r-(1r,4r,6r,10s))-4,12,12-trimethyl-9-methylene-5-oxatricyclo(8.2.0.04,6)dodecane

,6r,10s)-

0s)-

4,11,11-Trimethyl-8-methylene-5-oxatricyclo(8.2.0.0(4,6))dodecane

4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.]dodecane (caryophyllene oxide)

4theta,6theta,10s)]-thet

5-)xatricyclo[8.2.0.0(4,6))dodecane, 6,,11,11-trimethyl-2-methylene, [1R-(1R*,4R*,6R*,10S*)]-

5-oxatricyclo(8.2.0.0(4,6))dodecane,4,12,12-trimethyl-9-methylene-,(1r-(1r*,4

5-oxatricyclo(8.2.0.0(sup4,6))dodecane,4,12,12-trimethyl-9-methylene-,(1r,4r

5-Oxatricyclo(8.2.0.0<sup>4,6</sup>)dodecane, 4,12,12-trimethyl-9-methylene-, (1R,4R,6R,10S)-

5-oxatricyclo(8.20.0(4,6))dodecane,4,12,12-trimethyl-9-methylene-,(1r,4r,6r,1

5-Oxatricyclo[8.2.0.0(4,6)-]dodecane, 4,12,12-trimethyl-9-methylene-, [1R-(1R*,4R*,6R*,10S*)]-

5-oxatricyclo[8.2.0.04,6]dodecane,,12,12-trimethyl-3-methylene-[1r-

6]dodecane,4,12,12-trimethyl-9-methylene-,[1R-(1R*,4R*,6R*,10S*)]-5-Oxatricyclo[8.2.0.04

6]dodecane,4,12,12-trimethyl-9-methylene-5-oxatricyclo[8.2.0.0[1theta-(1

6r*,10s*))-r

beta-Caryophyllene oxide

beta-caryophylleneepoxide

beta-caryophylleneoxide

Caryophylene oxide

(-)-Caryophyllene oxide, 95% 10GR

CARYLOPHYLLENE OXIDE

(-)-CARYOPHYLLENE OXIDE, >= 99.0 % G

(-)-Caryophyllene oxide@100 μg/mL in Methanol

(-)-Caryophyllene oxide, 95%

Caryopyllene oxide

Caryophyllene oxide USP/EP/BP

β-Caryophyllene Epoxide

TIANFUCHEM--1139-30-6--High purity CARYOPHYLLENE OXIDE in stock

(-)-Caryophyllene oxide, 95%,

DXP 5648