4-THIOURIDINE

Product Name: 4-THIOURIDINE
CAS No.: 13957-31-8
Chemical Name: 4-THIOURIDINE
Synonyms: 4-SH-Ur;NSC 518132;thiouridine;4-THIOURIDINE;THIOURIDINE, 4-;Uridine, 4-thio-;1-((2R,3R,4S,5R);4-Thio-D-uridine;4-thiouridineapprox.;4-THIOURIDINE USP/EP/BP
CBNumber: CB3202841
Molecular Formula: C9H12N2O5S
Formula Weight: 260.27
MOL File: 13957-31-8.mol

More

Less

4-THIOURIDINE Property

Melting point:: 139-140℃ (ethanol )
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 4.75±0.20(Predicted)
form: crystalline
color: light yellow
PH: 8.2
Water Solubility: Soluble in water (20 mg/ml), and methanol (10 mg/ml).
λmax: 245，331 (pH 6.5)；316 (pH 12)
InChIKey: ZLOIGESWDJYCTF-XVFCMESISA-N
CAS DataBase Reference: 13957-31-8(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T4509
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 25mg
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: T4509
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 100mg
Price: $592
Updated: 2024/03/01

Alfa Aesar

Product number: J60679
Product name: 4-Thiouridine, 98+%
Packaging: 100mg
Price: $499
Updated: 2024/03/01

Alfa Aesar

Product number: J60679
Product name: 4-Thiouridine
Purity: 98+%
Packaging: 250mg
Price: $749
Updated: 2024/03/01

Cayman Chemical

Product number: 16373
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

More

Less

4-THIOURIDINE Chemical Properties,Usage,Production

Description

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Uses

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

Uses

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Definition

ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.

General Description

4-Thiouridine is a photoreactive uridine analog.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

storage

Store at -20°C

4-THIOURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-THIOURIDINE Suppliers

Canada 1 China 118 Germany 2 India 4 Russia 1 Switzerland 1 United Kingdom 3 United States 18 Global 148

Zhengzhou Granlen Sciences, ltd.

Tel: 0371-85513397 +86-18610099868;
Email: info@granlen.com
Country: China
ProdList: 1842
Advantage: 58

Fuyang Ziyi Biological Pharmaceutical Co., Ltd.

Tel: 19308655899
Fax: -
Email: 2677609105@qq.com
Country: China
ProdList: 468
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13856024262
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

More

Less

View Lastest Price from 4-THIOURIDINE manufacturers

NewCan Biotech Limited

Product: 4-Thiouridine;4-SH-Ur 13957-31-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100g
Release date: 2024-05-17

Honest Joy Holdings Limited

Product: 4-Thiouridine 13957-31-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 4-THIOURIDINE 13957-31-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

13957-31-8, 4-THIOURIDINERelated Search:

4-THIOURIDINE 2-THIOURIDINE 5-METHYL-2-THIOURIDINE 5-methylaminomethyl-2-thiouridine 5-FLUORO-2'-O-METHYL-4-THIOURIDINE 4-THIO-UMP DISODIUM SALT 5-BROMO-2'-DEOXY-4-THIOURIDINE,5-BROMO-2''-DEOXY-4-THIOURIDINE 98.0% 4-thiouridine triphosphate 2'-deoxy-4'-thiouridine 5-(2-bromovinyl)-2'-deoxy-4'-thiouridine 5-(carboxymethylaminomethyl)-2-thiouridine 2'-O-methyl-2-thiouridine 6-aza-2-thiouridine THIOURIDINE, 4-(RG) 4-THIOURIDINE-5'-TRIPHOSPHATE LITHIUM SALT 4-THIOURIDINE [2-14C] 2',3'-Didehydro-2',3'-dideoxy-4-thiouridine 5-[(E)-2-Bromoethenyl]-2'-deoxy-4'-thiouridine

1-((2R,3R,4S,5R)

-4-thioxo-3,4-dihydropyrimidin-2(1H)

THIOURIDINE, 4-

4-THIOURIDINE

thiouridine

4-thiouridineapprox.

4-Thio-D-uridine

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyriMidin-2(1H)-one

4-SH-Ur

NSC 518132

Uridine, 4-thio-

4-THIOURIDINE USP/EP/BP

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one

4-thiouridine,RNA-modified nucleoside s4U

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one

13957-31-8

Biochemicals and Reagents

BioChemical

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Bases & Related Reagents

Nucleotides

Sulfur & Selenium Compounds