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4-THIOURIDINE

Product Name
4-THIOURIDINE
CAS No.
13957-31-8
Chemical Name
4-THIOURIDINE
Synonyms
4-SH-Ur;NSC 518132;thiouridine;4-THIOURIDINE;THIOURIDINE, 4-;Uridine, 4-thio-;1-((2R,3R,4S,5R);4-Thio-D-uridine;4-thiouridineapprox.;4-THIOURIDINE USP/EP/BP
CBNumber
CB3202841
Molecular Formula
C9H12N2O5S
Formula Weight
260.27
MOL File
13957-31-8.mol
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4-THIOURIDINE Property

Melting point:
139-140℃ (ethanol )
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
4.75±0.20(Predicted)
form 
crystalline
color 
light yellow
PH
8.2
Water Solubility 
Soluble in water (20 mg/ml), and methanol (10 mg/ml).
λmax
245,331 (pH 6.5);316 (pH 12)
InChIKey
ZLOIGESWDJYCTF-XVFCMESISA-N
CAS DataBase Reference
13957-31-8(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T4509
Product name
4-Thiouridine
Purity
≥98%
Packaging
25mg
Price
$225
Updated
2024/03/01
Sigma-Aldrich
Product number
T4509
Product name
4-Thiouridine
Purity
≥98%
Packaging
100mg
Price
$592
Updated
2024/03/01
Alfa Aesar
Product number
J60679
Product name
4-Thiouridine, 98+%
Packaging
100mg
Price
$499
Updated
2024/03/01
Alfa Aesar
Product number
J60679
Product name
4-Thiouridine
Purity
98+%
Packaging
250mg
Price
$749
Updated
2024/03/01
Cayman Chemical
Product number
16373
Product name
4-Thiouridine
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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4-THIOURIDINE Chemical Properties,Usage,Production

Description

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Uses

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

Uses

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Definition

ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.

General Description

4-Thiouridine is a photoreactive uridine analog.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

storage

Store at -20°C

4-THIOURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-THIOURIDINE Suppliers

Zhengzhou Granlen Sciences, ltd.
Tel
0371-85513397 +86-18610099868;
Email
info@granlen.com
Country
China
ProdList
1842
Advantage
58
Fuyang Ziyi Biological Pharmaceutical Co., Ltd.
Tel
19308655899
Fax
-
Email
2677609105@qq.com
Country
China
ProdList
468
Advantage
58
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2997
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
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View Lastest Price from 4-THIOURIDINE manufacturers

NewCan Biotech Limited
Product
4-Thiouridine;4-SH-Ur 13957-31-8
Price
US $0.00-0.00/g
Min. Order
1g
Purity
97%
Supply Ability
100g
Release date
2024-05-17
Honest Joy Holdings Limited
Product
4-Thiouridine 13957-31-8
Price
US $0.00/KG
Min. Order
1KG
Purity
97.6%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
4-THIOURIDINE 13957-31-8
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-21

13957-31-8, 4-THIOURIDINERelated Search:


  • 1-((2R,3R,4S,5R)
  • -4-thioxo-3,4-dihydropyrimidin-2(1H)
  • THIOURIDINE, 4-
  • 4-THIOURIDINE
  • thiouridine
  • 4-thiouridineapprox.
  • 4-Thio-D-uridine
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyriMidin-2(1H)-one
  • 4-SH-Ur
  • NSC 518132
  • Uridine, 4-thio-
  • 4-THIOURIDINE USP/EP/BP
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
  • 4-thiouridine,RNA-modified nucleoside s4U
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one
  • 13957-31-8
  • Biochemicals and Reagents
  • BioChemical
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleoside Analogs
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Bases & Related Reagents
  • Nucleotides
  • Sulfur & Selenium Compounds