4-THIOURIDINE

Product Name: 4-THIOURIDINE
CAS No.: 13957-31-8
Chemical Name: 4-THIOURIDINE
Synonyms: 4-SH-Ur;NSC 518132;thiouridine;4-THIOURIDINE;THIOURIDINE, 4-;Uridine, 4-thio-;1-((2R,3R,4S,5R);4-Thio-D-uridine;4-thiouridineapprox.;4-THIOURIDINE USP/EP/BP
CBNumber: CB3202841
Molecular Formula: C9H12N2O5S
Formula Weight: 260.27
MOL File: 13957-31-8.mol

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4-THIOURIDINE Property

Melting point:: 139-140℃ (ethanol )
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 4.75±0.20(Predicted)
form: crystalline
color: light yellow
PH: 8.2
Water Solubility: Soluble in water (20 mg/ml), and methanol (10 mg/ml).
λmax: 245，331 (pH 6.5)；316 (pH 12)
InChIKey: ZLOIGESWDJYCTF-XVFCMESISA-N
CAS DataBase Reference: 13957-31-8(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T4509
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 25mg
Price: $225
Updated: 2024/03/01

Sigma-Aldrich

Product number: T4509
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 100mg
Price: $592
Updated: 2024/03/01

Alfa Aesar

Product number: J60679
Product name: 4-Thiouridine, 98+%
Packaging: 100mg
Price: $499
Updated: 2024/03/01

Alfa Aesar

Product number: J60679
Product name: 4-Thiouridine
Purity: 98+%
Packaging: 250mg
Price: $749
Updated: 2024/03/01

Cayman Chemical

Product number: 16373
Product name: 4-Thiouridine
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

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4-THIOURIDINE Chemical Properties,Usage,Production

Description

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Uses

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

Uses

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Definition

ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.

General Description

4-Thiouridine is a photoreactive uridine analog.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

storage

Store at -20°C

4-THIOURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-THIOURIDINE Suppliers

Canada 1 China 118 Germany 2 India 4 Russia 1 Switzerland 1 United Kingdom 3 United States 18 Global 148

Toronto Research Chemicals

Tel: --
Fax: --
Email: info@trc-canada.com
Country: Canada
ProdList: 6038
Advantage: 71

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View Lastest Price from 4-THIOURIDINE manufacturers

NewCan Biotech Limited

Product: 4-Thiouridine;4-SH-Ur 13957-31-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 100g
Release date: 2024-05-17

Honest Joy Holdings Limited

Product: 4-Thiouridine 13957-31-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 4-THIOURIDINE 13957-31-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

13957-31-8, 4-THIOURIDINERelated Search:

4-THIOURIDINE 2-THIOURIDINE 5-METHYL-2-THIOURIDINE 5-methylaminomethyl-2-thiouridine 5-FLUORO-2'-O-METHYL-4-THIOURIDINE 4-THIO-UMP DISODIUM SALT 5-BROMO-2'-DEOXY-4-THIOURIDINE,5-BROMO-2''-DEOXY-4-THIOURIDINE 98.0% 4-thiouridine triphosphate 2'-deoxy-4'-thiouridine 5-(2-bromovinyl)-2'-deoxy-4'-thiouridine 5-(carboxymethylaminomethyl)-2-thiouridine 2'-O-methyl-2-thiouridine 6-aza-2-thiouridine THIOURIDINE, 4-(RG) 4-THIOURIDINE-5'-TRIPHOSPHATE LITHIUM SALT 4-THIOURIDINE [2-14C] 2',3'-Didehydro-2',3'-dideoxy-4-thiouridine 5-[(E)-2-Bromoethenyl]-2'-deoxy-4'-thiouridine

1-((2R,3R,4S,5R)

-4-thioxo-3,4-dihydropyrimidin-2(1H)

THIOURIDINE, 4-

4-THIOURIDINE

thiouridine

4-thiouridineapprox.

4-Thio-D-uridine

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyriMidin-2(1H)-one

4-SH-Ur

NSC 518132

Uridine, 4-thio-

4-THIOURIDINE USP/EP/BP

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one

4-thiouridine,RNA-modified nucleoside s4U

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-thioxo-pyrimidin-2-one

13957-31-8

Biochemicals and Reagents

BioChemical

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Bases & Related Reagents

Nucleotides

Sulfur & Selenium Compounds