4-THIOURIDINE
- Product Name
- 4-THIOURIDINE
- CAS No.
- 13957-31-8
- Chemical Name
- 4-THIOURIDINE
- Synonyms
- 4-SH-Ur;NSC 518132;thiouridine;4-THIOURIDINE;THIOURIDINE, 4-;Uridine, 4-thio-;1-((2R,3R,4S,5R);4-Thio-D-uridine;4-thiouridineapprox.;4-THIOURIDINE USP/EP/BP
- CBNumber
- CB3202841
- Molecular Formula
- C9H12N2O5S
- Formula Weight
- 260.27
- MOL File
- 13957-31-8.mol
4-THIOURIDINE Property
- Melting point:
- 139-140℃ (ethanol )
- Density
- 1.72±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- pka
- 4.75±0.20(Predicted)
- form
- crystalline
- color
- light yellow
- PH
- 8.2
- biological source
- synthetic (organic)
- Water Solubility
- Soluble in water (20 mg/ml), and methanol (10 mg/ml).
- λmax
- 245，331 (pH 6.5)；316 (pH 12)
- InChIKey
- ZLOIGESWDJYCTF-XVFCMESISA-N
- CAS DataBase Reference
- 13957-31-8(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T4509
- Product name
- 4-Thiouridine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- T4509
- Product name
- 4-Thiouridine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $592
- Updated
- 2024/03/01
- Product number
- J60679
- Product name
- 4-Thiouridine, 98+%
- Packaging
- 100mg
- Price
- $499
- Updated
- 2024/03/01
- Product number
- J60679
- Product name
- 4-Thiouridine
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $749
- Updated
- 2024/03/01
- Product number
- 16373
- Product name
- 4-Thiouridine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
4-THIOURIDINE Chemical Properties,Usage,Production
Description
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.
Uses
Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.
Uses
4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.
Definition
ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.
General Description
4-Thiouridine is a photoreactive uridine analog.
Biochem/physiol Actions
4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.
storage
Store at -20°C
4-THIOURIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-THIOURIDINE manufacturers
- Product
- 4-Thiouridine;4-SH-Ur 13957-31-8
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 100g
- Release date
- 2024-05-17
- Product
- 4-Thiouridine 13957-31-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 4-THIOURIDINE 13957-31-8
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21