2-AMINO-5-IODO-3-NITROPYRIDINE
- Product Name
- 2-AMINO-5-IODO-3-NITROPYRIDINE
- CAS No.
- 25391-57-5
- Chemical Name
- 2-AMINO-5-IODO-3-NITROPYRIDINE
- Synonyms
- Zinc04202918;5-iodo-3-nitro-2-pyridinamine;5-iodo-3-nitropyridin-2-aMine;2-PYRIDINAMINE,5-IODO-3-NITRO;2-Amino-3-nitro-5-iodopyridine;2-AMINO-5-IODO-3-NITROPYRIDINE;5-IODO-3-NITRO-PYRIDIN-2-YLAMINE;2-Amino-5-iodo-3-nitropyridine 95+%;2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB3203020
- Molecular Formula
- C5H4IN3O2
- Formula Weight
- 265.01
- MOL File
- 25391-57-5.mol
2-AMINO-5-IODO-3-NITROPYRIDINE Property
- Melting point:
- 215-219 °C (lit.)
- Boiling point:
- 365.4±42.0 °C(Predicted)
- Density
- 2.229±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 0.41±0.49(Predicted)
- Appearance
- Light yellow to yellow Solid
- CAS DataBase Reference
- 25391-57-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A611350
- Product name
- 2-Amino-5-iodo-3-nitropyridine
- Packaging
- 5g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- 415283
- Product name
- 2-Amino-5-iodo-3-nitropyridine
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- A611350
- Product name
- 2-Amino-5-iodo-3-nitropyridine
- Packaging
- 25g
- Price
- $1450
- Updated
- 2021/12/16
- Product number
- 2060AB
- Product name
- 5-Iodo-3-nitropyridin-2-amine
- Packaging
- 25g
- Price
- $344
- Updated
- 2021/12/16
- Product number
- FA46246
- Product name
- 2-Amino-5-iodo-3-nitropyridine
- Packaging
- 50g
- Price
- $820
- Updated
- 2021/12/16
2-AMINO-5-IODO-3-NITROPYRIDINE Chemical Properties,Usage,Production
Uses
2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.
Synthesis
4214-75-9
25391-57-5
To a 250 mL three-necked flask were added 2-amino-3-nitropyridine (10.0 g, 72.0 mmol), acetic acid (44 mL) and water (10 mL). The mixture was heated to 90°C and then periodic acid (3.28 g, 14.4 mmol) and concentrated sulfuric acid (1.3 mL) at a mass percent concentration of 98% were added sequentially. After stirring for 10 min, iodine (9.1 g, 36.0 mmol) was added and stirring was continued for 60 min at this temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently poured into saturated aqueous sodium thiosulfate solution (100 mL). The solid product was separated by filtration and washed sequentially with saturated brine (50 mL x 2) and petroleum ether (50 mL x 2). The crude product was recrystallized using a mixed solvent of petroleum ether and ethyl acetate (5:1, v/v) to afford a high purity yellow solid 2-amino-5-iodo-3-nitropyridine (17.57 g, 69.1 mmol, 96% yield).
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[2] Patent: CN107325045, 2017, A. Location in patent: Paragraph 0006; 0009
[3] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 37
[4] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0152
2-AMINO-5-IODO-3-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-5-IODO-3-NITROPYRIDINE manufacturers
- Product
- 2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07
- Product
- 2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-01-29