2-AMINO-3-IODO-5-NITROPYRIDINE
- Product Name
- 2-AMINO-3-IODO-5-NITROPYRIDINE
- CAS No.
- 25391-56-4
- Chemical Name
- 2-AMINO-3-IODO-5-NITROPYRIDINE
- Synonyms
- 3-iodo-5-nitro-2-pyridinamine;3-IODO-5-NITROPYRIDIN-2-AMINE;2-AMINO-3-IODO-5-NITROPYRIDINE;2-Pyridinamine, 3-iodo-5-nitro-;3-Iodo-5-nitro-pyridin-2-ylamine;2-AMINO-3-IODO-5-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB2782292
- Molecular Formula
- C5H4IN3O2
- Formula Weight
- 265.01
- MOL File
- 25391-56-4.mol
2-AMINO-3-IODO-5-NITROPYRIDINE Property
- Melting point:
- 231-236 °C
- Boiling point:
- 391.7±42.0 °C(Predicted)
- Density
- 2.229±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 0.41±0.49(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 694738
- Product name
- 2-Amino-3-iodo-5-nitropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.1
- Updated
- 2023/06/20
- Product number
- 694738
- Product name
- 2-Amino-3-iodo-5-nitropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $197
- Updated
- 2022/05/15
- Product number
- I715710
- Product name
- 3-Iodo-5-nitropyridin-2-amine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J50360
- Product name
- 2-Amino-3-iodo-5-nitropyridine
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 046760
- Product name
- 3-Iodo-5-nitro-2-pyridinamine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $16
- Updated
- 2021/12/16
2-AMINO-3-IODO-5-NITROPYRIDINE Chemical Properties,Usage,Production
Uses
Useful starter in azaindole chemistry.
Synthesis
4214-76-0
25391-56-4
General procedure for the synthesis of 2-amino-3-iodo-5-nitropyridine from 2-amino-5-nitropyridine: 5-nitropyridin-2-amine (14 g, 100 mmol), potassium iodide (16.6 g, 100 mmol) and potassium iodate (10.7 g, 50 mmol) were dissolved in dilute sulfuric acid (2 N, 200 mL). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the pH was adjusted slowly by adding sodium hydroxide solution (5 N, 80 mL) to about 10. The resulting solid product was collected by filtration, washed sequentially with deionized water and ethanol and finally dried under vacuum. The target compound 2-amino-3-iodo-5-nitropyridine (25 g, 94% yield) was obtained. The structure of the product was characterized by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 6.80-8.40 (br s, 2H), 8.57 (d, J = 2.4 Hz, 1H), 8.84 (d, J = 2.4 Hz, 1H); MS (ESI) m/z 264 [M+H]+.
References
[1] Synthesis, 2005, # 15, p. 2503 - 2506
[2] Patent: WO2010/32, 2010, A1. Location in patent: Page/Page column 78-79
[3] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 14, p. 3853 - 3860
[4] Patent: WO2012/127506, 2012, A1. Location in patent: Page/Page column 56-57
[5] Organic Process Research and Development, 2015, vol. 19, # 9, p. 1282 - 1285
2-AMINO-3-IODO-5-NITROPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-3-IODO-5-NITROPYRIDINE manufacturers
- Product
- 2-AMINO-3-IODO-5-NITROPYRIDINE 25391-56-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-07
- Product
- 2-AMINO-3-IODO-5-NITROPYRIDINE 25391-56-4
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10