2-Amino-3-bromo-5-(trifluoromethyl)-pyridine

Product Name: 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine
CAS No.: 79456-30-7
Chemical Name: 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine
Synonyms: 2-Amino-3-bromo-5-(trifL;2-Amino-3-bromo-5-(trifluorome;3-Bromo-5-(trifluoromethyl)pyridin-2-amine;3-bromo-5-(trifluoromethyl)pyridine-2-amine;3-Bromo-5-trifluoromethyl-pyridin-2-ylamine;2-Amino-3-bromo-5-(trifluoromethyl)-pyridine;2-Pyridinamine, 3-bromo-5-(trifluoromethyl)-;2-Amino-3-bromo-5-(trifluoromethyl)pyridine,97%;2-Amino-3-bromo-5-(trifluoromethyl)pyridine 98+%;3-Bromo-5-(trifluoromethyl)pyridin-2-amine, 6-Amino-5-bromo-alpha,alpha,alpha-trifluoro-3-picoline
CBNumber: CB71471093
Molecular Formula: C6H4BrF3N2
Formula Weight: 241.01
MOL File: 79456-30-7.mol

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2-Amino-3-bromo-5-(trifluoromethyl)-pyridine Property

Melting point:: 98-101℃
Boiling point:: 221.7±40.0 °C(Predicted)
Density: 1.790±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.79±0.49(Predicted)
form: solid
color: Light Yellow
InChI: InChI=1S/C6H4BrF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)
InChIKey: KBNACDZKKVMULE-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(C(F)(F)F)C=C1Br

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A595140
Product name: 2-Amino-3-bromo-5-(trifluoromethyl)pyridine
Packaging: 5g
Price: $115
Updated: 2021/12/16

TRC

Product number: A595140
Product name: 2-Amino-3-bromo-5-(trifluoromethyl)pyridine
Packaging: 25g
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0002644
Product name: 2-AMINO-3-BROMO-5-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $606.38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0002644
Product name: 2-AMINO-3-BROMO-5-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 5G
Price: $874.34
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0002644
Product name: 2-AMINO-3-BROMO-5-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 25G
Price: $1566.18
Updated: 2021/12/16

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2-Amino-3-bromo-5-(trifluoromethyl)-pyridine Chemical Properties,Usage,Production

Uses

2-Amino-3-bromo-5-(trifluoromethyl)pyridine is a useful research chemical. It acts as a reagent used in the preparation of fluazaindolizine, a new highly effective and selective product for the control of plant parasitic nematodes.

Synthesis

74784-70-6

79456-30-7

The general procedure for the synthesis of 2-amino-3-bromo-5-trifluoromethylpyridine from 2-amino-5-trifluoromethylpyridine was as follows: 71 g of N-bromosuccinimide was added in batches to a mixture containing 65 g of 2-amino-5-trifluoromethylpyridine and 100 ml of chloroform under cooling conditions in an ice-water bath, with the temperature increasing during the reaction. Subsequently, the reaction mixture was stirred at room temperature for 1 hour. Next, the reaction mixture was heated to 80°C and stirred at this temperature for 30 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by sequentially adding saturated aqueous sodium thiosulfate and saturated aqueous sodium bicarbonate, followed by extraction with chloroform. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Finally, the residue was purified by silica gel column chromatography to give 96 g of the target product 2-amino-3-bromo-5-trifluoromethylpyridine. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 8.27 (1H, d), 7.86 (1H, d), 5.38 (2H, brs).

References

[1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 12, p. 1715 - 1720
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 19, p. 2777 - 2782
[3] Patent: US5861419, 1999, A
[4] Patent: US6046217, 2000, A
[5] Patent: US6004950, 1999, A

2-Amino-3-bromo-5-(trifluoromethyl)-pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-bromo-5-(trifluoromethyl)-pyridine Suppliers

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View Lastest Price from 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine 79456-30-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Henan Fengda Chemical Co., Ltd

Product: 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine 79456-30-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Career Henan Chemical Co

Product: 2-Amino-3-bromo-5-(trifluoromethyl)-pyridine 79456-30-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-26

79456-30-7, 2-Amino-3-bromo-5-(trifluoromethyl)-pyridineRelated Search:

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2-Amino-3-bromo-5-(trifluoromethyl)pyridine,97%

79456-30-7

79546-30-7

C6H4BrF3N2

amine|alkyl bromide

Pyridines ,Heterocyclic Acids,Quinolines ,Quinazolines