3-iodo-5-(trifluoromethyl)-2-pyridinylamine
- Product Name
- 3-iodo-5-(trifluoromethyl)-2-pyridinylamine
- CAS No.
- 211308-82-6
- Chemical Name
- 3-iodo-5-(trifluoromethyl)-2-pyridinylamine
- Synonyms
- 3-IODO-5-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;3-iodo-5-(trifluoromethyl)pyridine-2-amine;-iodo-5-(trifluoromethyl)-2-pyridinylamine;3-Iodo-5-trifluoroMethyl-pyridin-2-ylaMine;3-iodo-5-(trifluoromethyl)-2-pyridinylamine;2-Pyridinamine, 3-iodo-5-(trifluoromethyl)-;2-Amino-3-iodo-5-(trifluoromethyl)-pyridine;3-Iodo-5-(trifluoromethyl)-2-pyridinylamine(en);1H-Imidazole-4-carboxylicacid,1-(7-bromophenyl)-;3-IODO-5-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE (NOT RESTRICTED/P - ROHIBITED) (LAB RESEARCH CHEMICAL)
- CBNumber
- CB81526574
- Molecular Formula
- C6H4F3IN2
- Formula Weight
- 288.01
- MOL File
- 211308-82-6.mol
3-iodo-5-(trifluoromethyl)-2-pyridinylamine Property
- Melting point:
- 97-98°
- Boiling point:
- 269.4±40.0 °C(Predicted)
- Density
- 2.049±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.15±0.49(Predicted)
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- ADE000574
- Product name
- 3-Iodo-5-(trifluoromethyl)pyridin-2-amine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $761
- Updated
- 2023/06/20
- Product number
- I737085
- Product name
- 3-Iodo-5-(trifluoromethyl)pyridin-2-amine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 0788AB
- Product name
- 2-Amino-3-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
- Product number
- 046925
- Product name
- 3-Iodo-5-(trifluoromethyl)-2-pyridinylamine
- Purity
- >95%
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- PC200189
- Product name
- 2-Amino-3-iodo-5-(trifluoromethyl)pyridine
- Packaging
- 5g
- Price
- $322
- Updated
- 2021/12/16
3-iodo-5-(trifluoromethyl)-2-pyridinylamine Chemical Properties,Usage,Production
Synthesis
74784-70-6
211308-82-6
Concentrated sulfuric acid (5 mL), periodate (26 g, 123 mmol) and iodine (62 g, 246 mmol) were sequentially added to a stirred solution of 5-(trifluoromethyl)pyridin-2-amine (100 g, 617 mmol) in acetic acid (1 L) under argon protection and at room temperature. The reaction mixture was heated to 80 °C and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was cooled to 0 °C and alkalized with sodium hydroxide solution (200 mL) to precipitate the solid product. The solid was collected by filtration and concentrated under vacuum to afford the target compound 3-iodo-5-(trifluoromethyl)pyridin-2-amine (120 g, 67% yield) as an off-white solid. The product was characterized by 1H NMR (DMSO-d6, 500 MHz): δ 8.27 (s, 1H), 8.16 (s, 1H), 6.87 (brs, 2H); TLC conditions: 10% ethyl acetate/hexane (Rf 0.4).
References
[1] Patent: WO2008/79346, 2008, A1. Location in patent: Page/Page column 58
[2] Patent: WO2017/31325, 2017, A1. Location in patent: Paragraph 0522
[3] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 116; 117
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 3, p. 1160 - 1170
[5] Patent: US2005/277681, 2005, A1. Location in patent: Page/Page column 26
3-iodo-5-(trifluoromethyl)-2-pyridinylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-iodo-5-(trifluoromethyl)-2-pyridinylamine manufacturers
- Product
- 3-Iodo-5-(trifluoromethyl)pyridin-2-amine 211308-82-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-30